magnosalin and Arthritis

magnosalin has been researched along with Arthritis* in 1 studies

Other Studies

1 other study(ies) available for magnosalin and Arthritis

Article	Year
Synthesis of a magnosalin derivative, 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine, and the anti-angiogenic and anti-rheumatic effect on mice by oral administration. Bioorganic & medicinal chemistry letters, 2002, Feb-25, Volume: 12, Issue:4 We describe here the synthesis and the anti-angiogenic and anti-rheumatic activities of 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine (TAS-202), a derivative of magnosalin, which is a natural product isolated from Flos magnoliae. TAS-202 inhibited the proliferation of vascular endothelial cells more potently than magnosalin, and when given orally it inhibited basic fibroblast growth factor (bFGF)-induced angiogenesis and collagen-induced arthritis in mice. This magnosalin derivative with anti-angiogenic effects is a candidate for the treatment of rheumatoid arthritis. Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Antirheumatic Agents; Arthritis; Cell Division; Cyclobutanes; Endothelium, Vascular; Fibroblast Growth Factor 2; Hemoglobins; Humans; Male; Mice; Mice, Inbred Strains; Models, Animal; Neovascularization, Physiologic; Pyrimidines; Tumor Cells, Cultured	2002

Article

Year

Synthesis of a magnosalin derivative, 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine, and the anti-angiogenic and anti-rheumatic effect on mice by oral administration.

Bioorganic & medicinal chemistry letters, 2002, Feb-25, Volume: 12, Issue:4

We describe here the synthesis and the anti-angiogenic and anti-rheumatic activities of 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylaminopyrimidine (TAS-202), a derivative of magnosalin, which is a natural product isolated from Flos magnoliae. TAS-202 inhibited the proliferation of vascular endothelial cells more potently than magnosalin, and when given orally it inhibited basic fibroblast growth factor (bFGF)-induced angiogenesis and collagen-induced arthritis in mice. This magnosalin derivative with anti-angiogenic effects is a candidate for the treatment of rheumatoid arthritis.

Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Antirheumatic Agents; Arthritis; Cell Division; Cyclobutanes; Endothelium, Vascular; Fibroblast Growth Factor 2; Hemoglobins; Humans; Male; Mice; Mice, Inbred Strains; Models, Animal; Neovascularization, Physiologic; Pyrimidines; Tumor Cells, Cultured

2002