lolitrem B: neurotoxin from staggers-producing ryegrass pastures; MF C42-H55-N-O7 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 11947793 |
| MeSH ID | M0104384 |
| Synonym |
|---|
| lolitrem b |
| 4m63mt6w6m , |
| unii-4m63mt6w6m |
| 81771-19-9 |
| 7h-(1,3)dioxino(5'',4'':3'3')oxireno(4',4'a)(1)benzopyrano(5',6':6,7)indeno(1,2-b)isobenzofuro(5,6-e)indol-13(8h)-one, 1,4a,4b,5b,6,7a,9,9a,10,12,12a,16,16b,16c,17,18,18a,19a-octadecahydro-5b-hydroxy-1,1,10,10,12,12,16b,16c-octamethyl-3-(2-methyl-1-propen |
| C20551 |
| (1s,9r,13r,19s,22s,23s,25r,26r,28s,31s,33s,36r)-22-hydroxy-1,10,10,12,12,30,30,36-octamethyl-28-(2-methylprop-1-enyl)-11,24,27,29,32-pentaoxa-3-azadecacyclo[17.17.0.02,17.04,16.07,15.09,13.022,36.023,25.023,33.026,31]hexatriaconta-2(17),4(16),5,7(15)-tetr |
| AKOS040752655 |
Lolitrem B is an indole-diterpenoid neurotoxin. Main causative agent of ryegrass staggers, an animal disease associated with tremors and incoordination.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Lolitrem B is an indole-diterpenoid neurotoxin which is the main causative agent of ryegrass staggers, an animal disease associated with tremors and incoordination. " | ( Structural determinants of lolitrems for inhibition of BK large conductance Ca2+-activated K+ channels. Dalziel, JE; Dunlop, J; Finch, SC; Imlach, WL, 2009) | 1.8 |
Tremor dose-response curves were determined for mice dosed with the ryegrass neurotoxin lolitrem B, and the tremor-genic mycotoxin aflatrem. Lolit Rem B and ergotamine dosing in feed combined with neurological/gait assessment provides an effective model for investigation of PRGT and potential therapeutics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tremor dose-response curves were determined for mice dosed with the ryegrass neurotoxin lolitrem B, and the tremor-genic mycotoxin aflatrem." | ( The potent tremorgenic neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice. Gallagher, RT; Hawkes, AD, 1986) | 0.77 |
| " Feces reflected a dose-response for both mycotoxins, with values increasing most rapidly through 21 days then plateauing." | ( Co-exposure of the Mycotoxins Lolitrem B and Ergovaline in Steers Fed Perennial Ryegrass ( Lolium perenne) Straw: Metabolic Characterization of Excreta. Craig, AM; Duringer, JM; Murty, LD, 2018) | 0.77 |
| " CONCLUSIONS AND CLINICAL RELEVANCE Lolitrem B and ergotamine dosing in feed on a live weight basis combined with neurological/gait assessment provides an effective model for investigation of PRGT and potential therapeutics." | ( Development of a model for investigation of perennial ryegrass toxicosis in sheep. Combs, MD; Edwards, SH; Kessell, AE; Narayan, EJ; Piltz, J; Quinn, JC; Raidal, SR; Ramsay, J; Scherpenhuizen, JM, 2018) | 0.76 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 7 (14.29) | 18.7374 |
| 1990's | 6 (12.24) | 18.2507 |
| 2000's | 14 (28.57) | 29.6817 |
| 2010's | 21 (42.86) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (25.50) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (1.96%) | 5.53% |
| Reviews | 3 (5.88%) | 6.00% |
| Case Studies | 1 (1.96%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 46 (90.20%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||