Page last updated: 2024-08-02 22:18:06
lolitrem b
Description
lolitrem B: neurotoxin from staggers-producing ryegrass pastures; MF C42-H55-N-O7 [MeSH]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 11947793 |
| MeSH ID | M0104384 |
Synonyms (8)
| Synonym |
|---|
| lolitrem b |
| 4m63mt6w6m , |
| unii-4m63mt6w6m |
| 81771-19-9 |
| 7h-(1,3)dioxino(5'',4'':3'3')oxireno(4',4'a)(1)benzopyrano(5',6':6,7)indeno(1,2-b)isobenzofuro(5,6-e)indol-13(8h)-one, 1,4a,4b,5b,6,7a,9,9a,10,12,12a,16,16b,16c,17,18,18a,19a-octadecahydro-5b-hydroxy-1,1,10,10,12,12,16b,16c-octamethyl-3-(2-methyl-1-propen |
| C20551 |
| (1s,9r,13r,19s,22s,23s,25r,26r,28s,31s,33s,36r)-22-hydroxy-1,10,10,12,12,30,30,36-octamethyl-28-(2-methylprop-1-enyl)-11,24,27,29,32-pentaoxa-3-azadecacyclo[17.17.0.02,17.04,16.07,15.09,13.022,36.023,25.023,33.026,31]hexatriaconta-2(17),4(16),5,7(15)-tetr |
| AKOS040752655 |
Research
Studies (49)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 7 (14.29) | 18.7374 |
| 1990's | 6 (12.24) | 18.2507 |
| 2000's | 14 (28.57) | 29.6817 |
| 2010's | 21 (42.86) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 1 (1.96%) | 5.53% |
| Reviews | 3 (5.88%) | 6.00% |
| Case Studies | 1 (1.96%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 46 (90.20%) | 84.16% |
Combined effects of fungal alkaloids on intestinal motility in an in vitro rat model.Journal of animal science, , Volume: 91, Issue:11, 2013
Tremorgenic mycotoxins increase gastric smooth muscle activity of sheep reticulum and rumen in vitro.Research in veterinary science, , Volume: 74, Issue:1, 2003
Tremorgenic mycotoxins paxilline, penitrem and lolitrem B, the non-tremorgenic 31-epilolitrem B and electromyographic activity of the reticulum and rumen of sheep.Research in veterinary science, , Volume: 66, Issue:2, 1999
The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels.The Journal of pharmacology and experimental therapeutics, , Volume: 327, Issue:3, 2008
The potent tremorgenic neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice.Experientia, , Jul-15, Volume: 42, Issue:7, 1986
Amino acid neurotransmitter release from cerebrocortical synaptosomes of sheep with severe ryegrass staggers in New Zealand.Research in veterinary science, , Volume: 34, Issue:3, 1983
Neurotoxic mycotoxins: a review of fungal toxins that cause neurological disease in large animals.Journal of veterinary internal medicine, , Volume: 8, Issue:1
The biologic production unit for food animal veterinarians.Journal of the American Veterinary Medical Association, , Nov-15, Volume: 209, Issue:10, 1996
Staggers induced by consumption of perennial ryegrass in cattle and sheep from northern California.Journal of the American Veterinary Medical Association, , Aug-15, Volume: 199, Issue:4, 1991
Tremorgenic effects and functional metabolomics analysis of lolitrem B and its biosynthetic intermediates.Scientific reports, , 06-27, Volume: 9, Issue:1, 2019
A single exposure to the tremorgenic mycotoxin lolitrem B inhibits voluntary motor activity and spatial orientation but not spatial learning or memory in mice.Toxicon : official journal of the International Society on Toxinology, , Volume: 168, 2019
Ergovaline does not alter the severity of ryegrass staggers induced by lolitrem B.New Zealand veterinary journal, , Volume: 66, Issue:2, 2018
Clinical expression of lolitrem B (perennial ryegrass) intoxication in horses.Equine veterinary journal, , Volume: 44, Issue:3, 2012
Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: fescue foot and perennial ryegrass staggers.Veterinary and human toxicology, , Volume: 43, Issue:3, 2001
[Rhinopneumonia or mycotoxin intoxication? Neurologic phenomena in horses from a riding school].Tijdschrift voor diergeneeskunde, , Nov-15, Volume: 124, Issue:22, 1999
The potent tremorgenic neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice.Experientia, , Jul-15, Volume: 42, Issue:7, 1986
Tremorgenic mycotoxins.Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles, , Volume: 48, 1985
Ryegrass staggers: isolation of potent neurotoxins lolitrem A and lolitrem B from staggers-producing pastures.New Zealand veterinary journal, , Volume: 29, Issue:10, 1981
Effect of the mycotoxins penitrem, paxilline and lolitrem B on the electromyographic activity of skeletal and gastrointestinal smooth muscle of sheep.Research in veterinary science, , Volume: 62, Issue:2
The role of the Oregon State University Endophyte Service Laboratory in diagnosing clinical cases of endophyte toxicoses.Journal of agricultural and food chemistry, , Jul-30, Volume: 62, Issue:30, 2014
Correlation of ergovaline and lolitrem B levels in endophyte-infected perennial ryegrass (Lolium perenne).Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, , Volume: 13, Issue:4, 2001
Toxicological evaluation and bioaccumulation potential of lolitrem B, endophyte mycotoxin in Japanese black steers.Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, , Volume: 30, Issue:8, 2013
The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels.The Journal of pharmacology and experimental therapeutics, , Volume: 327, Issue:3, 2008
[Poisoning in livestock--as reference to human cases].Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, , Volume: 18, Issue:4, 2005
[Young perennial ryegrass staggers in a dairy herd].Tijdschrift voor diergeneeskunde, , May-01, Volume: 129, Issue:9, 2004
Detection of endophyte toxins in the imported perennial ryegrass straw.The Journal of veterinary medical science, , Volume: 63, Issue:9, 2001
Atypical pneumonia associated with ryegrass staggers in calves.Journal of the American Veterinary Medical Association, , Sep-15, Volume: 209, Issue:6, 1996
The biologic production unit for food animal veterinarians.Journal of the American Veterinary Medical Association, , Nov-15, Volume: 209, Issue:10, 1996
Staggers induced by consumption of perennial ryegrass in cattle and sheep from northern California.Journal of the American Veterinary Medical Association, , Aug-15, Volume: 199, Issue:4, 1991
Neurotoxic mycotoxins: a review of fungal toxins that cause neurological disease in large animals.Journal of veterinary internal medicine, , Volume: 8, Issue:1
Flow-mediated K(+) secretion in horses intoxicated with lolitrem B (perennial ryegrass staggers).New Zealand veterinary journal, , Volume: 61, Issue:3, 2013
Clinical expression of lolitrem B (perennial ryegrass) intoxication in horses.Equine veterinary journal, , Volume: 44, Issue:3, 2012
Detection of endophyte toxins in the imported perennial ryegrass straw.The Journal of veterinary medical science, , Volume: 63, Issue:9, 2001
[Rhinopneumonia or mycotoxin intoxication? Neurologic phenomena in horses from a riding school].Tijdschrift voor diergeneeskunde, , Nov-15, Volume: 124, Issue:22, 1999
[Ryegrass cramps in horses].Tijdschrift voor diergeneeskunde, , Dec-15, Volume: 120, Issue:24, 1995
Intoxication of horses by lolitrem B in ryegrass seed cleanings.Australian veterinary journal, , Volume: 62, Issue:6, 1985
Neurotoxic mycotoxins: a review of fungal toxins that cause neurological disease in large animals.Journal of veterinary internal medicine, , Volume: 8, Issue:1
The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels.The Journal of pharmacology and experimental therapeutics, , Volume: 327, Issue:3, 2008
The potent tremorgenic neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice.Experientia, , Jul-15, Volume: 42, Issue:7, 1986
Amino acid neurotransmitter release from cerebrocortical synaptosomes of sheep with severe ryegrass staggers in New Zealand.Research in veterinary science, , Volume: 34, Issue:3, 1983
Neurotoxic mycotoxins: a review of fungal toxins that cause neurological disease in large animals.Journal of veterinary internal medicine, , Volume: 8, Issue:1
Flow-mediated K(+) secretion in horses intoxicated with lolitrem B (perennial ryegrass staggers).New Zealand veterinary journal, , Volume: 61, Issue:3, 2013
Clinical expression of lolitrem B (perennial ryegrass) intoxication in horses.Equine veterinary journal, , Volume: 44, Issue:3, 2012
[Young perennial ryegrass staggers in a dairy herd].Tijdschrift voor diergeneeskunde, , May-01, Volume: 129, Issue:9, 2004
Detection of endophyte toxins in the imported perennial ryegrass straw.The Journal of veterinary medical science, , Volume: 63, Issue:9, 2001
Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: fescue foot and perennial ryegrass staggers.Veterinary and human toxicology, , Volume: 43, Issue:3, 2001
The biologic production unit for food animal veterinarians.Journal of the American Veterinary Medical Association, , Nov-15, Volume: 209, Issue:10, 1996
Atypical pneumonia associated with ryegrass staggers in calves.Journal of the American Veterinary Medical Association, , Sep-15, Volume: 209, Issue:6, 1996
[Ryegrass cramps in horses].Tijdschrift voor diergeneeskunde, , Dec-15, Volume: 120, Issue:24, 1995
Intoxication of horses by lolitrem B in ryegrass seed cleanings.Australian veterinary journal, , Volume: 62, Issue:6, 1985
Development of a model for investigation of perennial ryegrass toxicosis in sheep.New Zealand veterinary journal, , Volume: 66, Issue:6, 2018
Ergovaline does not alter the severity of ryegrass staggers induced by lolitrem B.New Zealand veterinary journal, , Volume: 66, Issue:2, 2018
Animal physiology and genetic aspects of ryegrass staggers in grazing sheep.New Zealand veterinary journal, , Volume: 65, Issue:4, 2017
Toxicity of endophyte-infected ryegrass hay containing high ergovaline level in lactating ewes.Journal of animal science, , Volume: 93, Issue:8, 2015
Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: fescue foot and perennial ryegrass staggers.Veterinary and human toxicology, , Volume: 43, Issue:3, 2001
The biologic production unit for food animal veterinarians.Journal of the American Veterinary Medical Association, , Nov-15, Volume: 209, Issue:10, 1996
Staggers induced by consumption of perennial ryegrass in cattle and sheep from northern California.Journal of the American Veterinary Medical Association, , Aug-15, Volume: 199, Issue:4, 1991
Amino acid neurotransmitter release from cerebrocortical synaptosomes of sheep with severe ryegrass staggers in New Zealand.Research in veterinary science, , Volume: 34, Issue:3, 1983
Effect of the mycotoxins penitrem, paxilline and lolitrem B on the electromyographic activity of skeletal and gastrointestinal smooth muscle of sheep.Research in veterinary science, , Volume: 62, Issue:2
Neurotoxic mycotoxins: a review of fungal toxins that cause neurological disease in large animals.Journal of veterinary internal medicine, , Volume: 8, Issue:1
Tremorgenic effects and functional metabolomics analysis of lolitrem B and its biosynthetic intermediates.Scientific reports, , 06-27, Volume: 9, Issue:1, 2019
A single exposure to the tremorgenic mycotoxin lolitrem B inhibits voluntary motor activity and spatial orientation but not spatial learning or memory in mice.Toxicon : official journal of the International Society on Toxinology, , Volume: 168, 2019
Ergovaline does not alter the severity of ryegrass staggers induced by lolitrem B.New Zealand veterinary journal, , Volume: 66, Issue:2, 2018
Clinical expression of lolitrem B (perennial ryegrass) intoxication in horses.Equine veterinary journal, , Volume: 44, Issue:3, 2012
Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: fescue foot and perennial ryegrass staggers.Veterinary and human toxicology, , Volume: 43, Issue:3, 2001
[Rhinopneumonia or mycotoxin intoxication? Neurologic phenomena in horses from a riding school].Tijdschrift voor diergeneeskunde, , Nov-15, Volume: 124, Issue:22, 1999
The potent tremorgenic neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice.Experientia, , Jul-15, Volume: 42, Issue:7, 1986
Tremorgenic mycotoxins.Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles, , Volume: 48, 1985
Ryegrass staggers: isolation of potent neurotoxins lolitrem A and lolitrem B from staggers-producing pastures.New Zealand veterinary journal, , Volume: 29, Issue:10, 1981
Effect of the mycotoxins penitrem, paxilline and lolitrem B on the electromyographic activity of skeletal and gastrointestinal smooth muscle of sheep.Research in veterinary science, , Volume: 62, Issue:2
Detection of endophyte toxins in the imported perennial ryegrass straw.The Journal of veterinary medical science, , Volume: 63, Issue:9, 2001
Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: fescue foot and perennial ryegrass staggers.Veterinary and human toxicology, , Volume: 43, Issue:3, 2001
[Rhinopneumonia or mycotoxin intoxication? Neurologic phenomena in horses from a riding school].Tijdschrift voor diergeneeskunde, , Nov-15, Volume: 124, Issue:22, 1999
Dosage (3)
| Article | Year |
|---|
Development of a model for investigation of perennial ryegrass toxicosis in sheep.
New Zealand veterinary journal, , Volume: 66, Issue:6 | 2018 |
Co-exposure of the Mycotoxins Lolitrem B and Ergovaline in Steers Fed Perennial Ryegrass ( Lolium perenne) Straw: Metabolic Characterization of Excreta.
Journal of agricultural and food chemistry, , Jun-27, Volume: 66, Issue:25 | 2018 |
The potent tremorgenic neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice.
Experientia, , Jul-15, Volume: 42, Issue:7 | 1986 |