Page last updated: 2024-09-05

l 767679 and beta-alanine

l 767679 has been researched along with beta-alanine in 4 studies

*beta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported. [MeSH]

*beta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported. [MeSH]

Compound Research Comparison

Studies
(l 767679)
Trials
(l 767679)
Recent Studies (post-2010)
(l 767679)
Studies
(beta-alanine)
Trials
(beta-alanine)
Recent Studies (post-2010) (beta-alanine)
7003,1772071,807

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baillie, TA; Breslin, MJ; Gorham, LM; Hartman, GD; Hutchinson, JH; Prueksaritanont, T; Vyas, KP1
Gorham, LM; Prueksaritanont, T; Yeh, KC1
Cohn, D; DeLuna, P; Gorham, LM; Leung, K; Lin, JH; Ma, B; Pang, J; Prueksaritanont, T; Xu, X1
Bednar, B; Bednar, RA; Cook, JJ; Cunningham, ME; Gould, RJ; Hartman, GD; Holahan, MA; Jumes, PA1

Other Studies

4 other study(ies) available for l 767679 and beta-alanine

ArticleYear
In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:8

    Topics: Administration, Oral; Animals; beta-Alanine; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Humans; Macaca mulatta; Male; Microsomes, Liver; Piperazines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Species Specificity

1997
Analysis of metabolite kinetics by deconvolution and in vivo-in vitro correlations of metabolite formation rates: studies of fibrinogen receptor antagonist ester prodrugs.
    Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:12

    Topics: Animals; beta-Alanine; Dogs; Esters; Macaca mulatta; Male; Microsomes, Liver; Piperazines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs

1997
In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and its carboxyl ester prodrug L-775,318. Roles of efflux and metabolism.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta-Alanine; Caco-2 Cells; Humans; Intestinal Mucosa; Male; Piperazines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil

1998
Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa.
    Blood, 1999, Jul-15, Volume: 94, Issue:2

    Topics: Animals; Autoantibodies; Autoimmune Diseases; Azepines; beta-Alanine; Blood Platelets; Disease Susceptibility; Dogs; Epitopes; Female; Fibrinolytic Agents; Humans; Immunoglobulin G; Macaca mulatta; Macromolecular Substances; Male; Molecular Structure; Oligopeptides; Pan troglodytes; Piperazines; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Primates; Protein Binding; Sulfonamides; Thrombocytopenia

1999