flustramine c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

flustramine C: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10041611
CHEMBL ID	524353
MeSH ID	M0499735

Synonyms (3)

Synonym
flustramine c
CHEMBL524353
(8br)-6-bromo-3-methyl-8b-(2-methylbut-3-en-2-yl)-1,2-dihydropyrrolo[2,3-b]indole

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID397820	Blockade of voltage-activated rat brain Nav1.2 sodium channel type 2 channel expressed in Xenopus laevis oocytes assessed as effect on evoked current by two-electrode voltage clamp method	2002	Journal of natural products, Nov, Volume: 65, Issue:11	Four new bromotryptamine derivatives from the marine bryozoan Flustra foliacea.
AID397819	Blockade of voltage-activated rat Kv1.4 potassium channel expressed in Xenopus laevis oocytes assessed as effect on evoked current upto 10 uM by two-electrode voltage clamp method	2002	Journal of natural products, Nov, Volume: 65, Issue:11	Four new bromotryptamine derivatives from the marine bryozoan Flustra foliacea.
AID397818	Blockade of voltage-activated rat Kv1.1 potassium channel expressed in Xenopus laevis oocytes assessed as effect on evoked current upto 10 uM by two-electrode voltage clamp method	2002	Journal of natural products, Nov, Volume: 65, Issue:11	Four new bromotryptamine derivatives from the marine bryozoan Flustra foliacea.
AID1858699	Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of biofilm formation at 100 uM incubated for 24 hrs by crystal violet method relative to control	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Tryptophan derived natural marine alkaloids and synthetic derivatives as promising antimicrobial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (66.67)	29.6817
2010's	1 (16.67)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (16.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2.06	1	pyrrole; secondary amine
indoline indoline: structure given in first source	2.06	1	indoles
niobium Niobium: A metal element atomic number 41, atomic weight 92.906, symbol Nb.	2.03	1	vanadium group element atom
brevianamide f brevianamide F: isolated from the endophyte from Aspergillus fumigatus associated with Melia azedarach L that could be used to develop a natural eco-friendly herbicide.structure in first source. brevianamide F : A pyrrolopyrazine that is hexahydropyrrolo[1,2-a]pyrazine-1,4-dione bearing an indol-3-ylmethyl substituent at position 3 (the 3S,8aS-diastereomer, obtained by formal cyclocondensation of L-tryptophan and L-proline).	3.41	1	dipeptide; indoles; pyrrolopyrazine	metabolite
2-oxindole 2-oxindole: RN given refers to parent cpd; structure. indolin-2-one : An indolinone carrying an oxo group at position 2.	2.02	1	gamma-lactam; indolinone
bromodeoxytopsentin bromodeoxytopsentin: from sponge Topsentia pachastrelloides; structure in first source. bromodeoxytopsentin : An aromatic ketone that is imidazole which is substituted by a 1H-indole-3-carbonyl group and a 6-bromo-1H-indol-3-yl group at positions 2 and 4, respectively. Isolated from the Mediterranean shallow-water sponge, Topsentia genetrix. It is a potent inhibitor of MRSA pyruvate kinase and exhibits antibacterial properties.	3.41	1	aromatic ketone; bromoindole; imidazoles; indole alkaloid	antibacterial agent; EC 2.7.1.40 (pyruvate kinase) inhibitor; marine metabolite
flustramine a flustramine A: from Flustra foliacea L.; exhibits muscle relaxant activity both in vivo & in vitro; structure given in first source	2.42	2
deformylflustrabromine deformylflustrabromine: has antineoplastic activity; isolated from Flustra folicea; structure in first source	3.85	3	tryptamines
fumiquinazoline f fumiquinazoline F: structure in first source. fumiquinazoline F : A fumiquinazoline that consists of pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione bearing a methyl substituent at position 1 and an indol-3-yl group at position 4.	3.41	1	fumiquinazoline; indoles; pyrazinoquinazoline

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.03	1	0

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