Compounds > fiscalin b
Page last updated: 2024-11-12

fiscalin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

fiscalin B: isolated from culture broth produced by Neosartorya fischeri; inhibits the binding of substance P ligand to human neurokinin receptor; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10091548
CHEMBL ID5094568
SCHEMBL ID23023412
MeSH IDM0217158

Synonyms (7)

Synonym
MEGXM0_000316
ACON1_000678
BRD-K77673266-001-01-4
fiscalin b
SCHEMBL23023412
(1s,4r)-4-(1h-indol-3-ylmethyl)-1-propan-2-yl-2,4-dihydro-1h-pyrazino[2,1-b]quinazoline-3,6-dione
CHEMBL5094568
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1815837Selectivity index, ratio of LD50 for cytotoxicity against Chinese hamster V79 cells to IC50 for antimalarial activity against CQ-sensitive Plasmodium falciparum 3D72022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
AID1815838Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay2022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
AID1815845Hemolytic activity against human erythrocytes at 0.04 to 10 uM incubated for 1 hr by microplate reader assay2022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
AID1815847Inhibition of Beta-hematin formation at 12 to 48 uM after 24 hrs by microplate reader assay2022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
AID1815846Hemolytic activity against human erythrocytes at <=10 uM incubated for 1 hr by microplate reader assay2022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
AID1815843Antileishmanial activity against axenic amastigote stage of Leishmania infantum infected in THP-1 cells assessed as reduction in parasite growth at 10 uM incubated for 72 hrs by luminescence analysis2022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
AID1815836Cytotoxicity against Chinese hamster V79 cells measured after 24 hrs by MTT assay2022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
AID1815840Antitrypanosomal activity against bloodstream form of Trypanosoma brucei Lister 427 assessed as parasite growth inhibition at 10 uM incubated for 72 hrs by resazurin staining based assay2022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
AID1815835Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 48 hrs by SYBR Green I dye based fluorescence assay2022ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
Indole-Containing Pyrazino[2,1-
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.23 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.03 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.4110aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.4110phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.4110aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
gliotoxin
Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.. gliotoxin : A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.		2.1110dipeptide;
organic disulfide;
organic heterotetracyclic compound;
pyrazinoindole		antifungal agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
immunosuppressive agent;
mycotoxin;
proteasome inhibitor
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.0210erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		2.9640azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
substance p
[no description available]		1.9810peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
glyantrypine
glyantrypine: structure given in first source; an anthranilic acid-containing metabolite isolated from Aspergillus clavatus		7.0210quinazolines
ergosterol
[no description available]		2.31103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
fumiquinazoline f
fumiquinazoline F: structure in first source. fumiquinazoline F : A fumiquinazoline that consists of pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione bearing a methyl substituent at position 1 and an indol-3-yl group at position 4.		7.0210fumiquinazoline;
indoles;
pyrazinoquinazoline
ConditionIndicatedRelationship StrengthStudiesTrials
Malignant Melanoma
[description not available]		02.3110
Cancer of Prostate
[description not available]		02.3110
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.3110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.3110
Cancer of Colon
[description not available]		02.1110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.1110