enpiroline has been researched along with Malaria* in 2 studies
2 other study(ies) available for enpiroline and Malaria
| Article | Year |
|---|---|
Mefloquine failure in a case of falciparum malaria induced with a multidrug-resistant isolate in a non-immune subject.
In a volunteer with infection induced by injection of the mefloquine-sensitive, multidrug-resistant Vietnam Smith isolate of P. falciparum, parasitemia recurred following treatment with the candidate antimalarial drug enpiroline. Parasitemia also recurred after subsequent treatment with mefloquine and again after retreatment with the same drug. All recurrences were at the RI level. Parasite drug sensitivities determined by a semi-automated isotope microdilution method after the second and third recurrences revealed a progressive decrease in sensitivity to all arylaminoalcohols tested (halofantrine, enpiroline, and mefloquine). Decreased sensitivity persisted after 30 days of isolate culture. The parallel changes in parasite sensitivity to the synthetic arylaminoalcohols argue for development of drugs which are chemically dissimilar. Topics: Adult; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Quinine; Quinolines | 1985 |
Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects.
WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case. Topics: Adolescent; Adult; Drug Evaluation; Humans; Malaria; Plasmodium falciparum; Pyridines | 1984 |