Compounds > dimethyl pyrocarbonate
Page last updated: 2024-11-04

dimethyl pyrocarbonate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Dimethyl pyrocarbonate (DMC) is a highly reactive and versatile reagent used in organic synthesis. It is typically synthesized by the reaction of phosgene with methanol. DMC is a powerful methylating agent, capable of introducing methyl groups into various functional groups, such as alcohols, amines, and carboxylic acids. DMC has found widespread applications in the pharmaceutical industry, where it is employed in the synthesis of various drugs and pharmaceuticals. Its strong methylating ability makes it an essential tool for the modification of bioactive molecules. Additionally, DMC is utilized in the production of pesticides, herbicides, and other agrochemicals. Furthermore, it serves as an important intermediate in the synthesis of polymers and resins. Due to its potent methylating activity, DMC poses potential health risks, including skin irritation, eye damage, and respiratory problems. As a result, it is important to handle DMC with caution and appropriate safety measures. The chemical's reactivity and versatile applications have led to ongoing research efforts to explore its potential in diverse fields, including medicine, agriculture, and materials science.'

Cross-References

ID SourceID
PubMed CID3086
CHEBI ID173546
SCHEMBL ID48007
MeSH IDM0171300

Synonyms (37)

Synonym
CHEBI:173546
methoxycarbonyl methyl carbonate
dimethyl dicarbonate
dimethyl oxydiformate
dicarbonic acid, dimethyl ester
formic acid, oxydi-, dimethyl ester
dimethyl pyrocarbonate
formic acid, oxydi-, dimethyl ester (7ci,8ci)
einecs 224-859-8
velcorin
methyl pyrocarbonate
dimethyl dicarbonate, for histidine methylation
4525-33-1
pyrocarbonic acid dimethyl ester
unii-1ay9229zmg
1ay9229zmg ,
dicarbonic acid, 1,3-dimethyl ester
hsdb 8117
FT-0625077
AKOS015892861
ins-242
e-242
dicarbonic acid, c,c'-dimethyl ester
dimethyl dicarbonate [fcc]
ins no.242
SCHEMBL48007
GZDFHIJNHHMENY-UHFFFAOYSA-N
dimethyldicarbonate
dimethylpyrocarbonate
DTXSID2052108
W-106157
Q416985
baycovin; depa;dekapex; diethyl dicarbonate;ue 5908
D95912
mfcd00008419
SY274597
EN300-317040

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
" Furthermore, the impact of EW in combination with dimethyl dicarbonate (DMDC) in reducing the microbial load and improving the overall quality of lettuce during refrigerated storage was evaluated."( Synergistic effect of electrolyzed water generated by sodium chloride combined with dimethyl dicarbonate for inactivation of Listeria monocytogenes on lettuce.
Li, C; Lu, H; Shi, H; Tian, S; Zhu, J, 2023)		0.91
"SEW in combination with DMDC can be used as a novel and potentially effective disinfection strategy for ensuring the safety of vegetable consumption."( Synergistic effect of electrolyzed water generated by sodium chloride combined with dimethyl dicarbonate for inactivation of Listeria monocytogenes on lettuce.
Li, C; Lu, H; Shi, H; Tian, S; Zhu, J, 2023)		0.91
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organooxygen compoundAn organochalcogen compound containing at least one carbon-oxygen bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (11.76)18.7374
1990's0 (0.00)18.2507
2000's2 (11.76)29.6817
2010's10 (58.82)24.3611
2020's3 (17.65)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.96 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index5.22 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.96)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (11.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (88.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetic acid
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.		3.2510monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
hydroxylamine
amino alcohol : An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.		1.9710hydroxylaminesalgal metabolite;
bacterial xenobiotic metabolite;
EC 1.1.3.13 (alcohol oxidase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
nitric oxide donor;
nucleophilic reagent
nickel
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.		2.2110metal allergen;
nickel group element atom		epitope;
micronutrient
sulfites
Sulfites: Inorganic salts of sulfurous acid.. sulfites : Any sulfurous acid derivative that is a salt or an ester of sulfurous acid.. organosulfonate oxoanion : An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid.. sulfite : A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3).		3.8830divalent inorganic anion;
sulfur oxide;
sulfur oxoanion
sulfur dioxide
Sulfur Dioxide: A highly toxic, colorless, nonflammable gas. It is used as a pharmaceutical aid and antioxidant. It is also an environmental air pollutant.		3.620sulfur oxideEscherichia coli metabolite;
food bleaching agent;
refrigerant
1,10-phenanthroline
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases		2.2110phenanthrolineEC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
diethyl pyrocarbonate
Diethyl Pyrocarbonate: Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.. diethyl pyrocarbonate : The diethyl ester of dicarbonic acid.		5.82160acyclic carboxylic anhydride
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		1.9710amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
allyl alcohol
allyl alcohol: structure. allylic alcohol : An alcohol where the hydroxy group is attached to a saturated carbon atom adjacent to a double bond (R groups may be H, organyl, etc.).. allyl alcohol : A propenol in which the C=C bond connects C-2 and C-3. It is has been found in garlic (Allium sativum). Formerly used as a herbicide for the control of various grass and weed seeds.		2.2110primary allylic alcohol;
propenol		antibacterial agent;
fungicide;
herbicide;
insecticide;
plant metabolite
manganese
Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.		1.9710elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
potassium metabisulfite
potassium metabisulfite: RN given refers to cpd with MF of K2-H2O5S2; request from searcher; structure		2.0410
keracyanin
cyanidin 3-rutinoside: an anthocyanin compound. cyanidin 3-O-rutinoside chloride : A member of the class of anthocyanin chlorides that has cyanidin 3-O-rutinoside as the cationic counterpart.		2.1310anthocyanin chlorides
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.1310D-glucopyranoseepitope;
mouse metabolite
1,7-phenanthroline
[no description available]		2.2110phenanthroline
1,4-dihydropyridine
[no description available]		2.2110
dihydropyridines
Dihydropyridines: Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.		2.2110
sorbic acid
Sorbic Acid: Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.. (2E,4E)-hexa-2,4-dienoic acid : A sorbic acid having trans-double bonds at positions 2 and 4; a food preservative that can induce cutaneous vasodilation and stinging upon topical application to humans. It is the most thermodynamically stable of the four possible geometric isomers possible, as well as the one with the highest antimicrobial activity.. sorbic acid : A hexadienoic acid with double bonds at C-2 and C-4; it has four geometrical isomers, of which the trans,trans-form is naturally occurring.		3.2510alpha,beta-unsaturated monocarboxylic acid;
sorbic acid
cinnamyl alcohol
cinnamyl alcohol: RN given refers to parent cpd without isomeric designation. (E)-cinnamyl alcohol : The E (trans) stereoisomer of cinnamyl alcohol.. cinnamyl alcohol : A primary alcohol comprising an allyl core with a hydroxy substituent at the 1-position and a phenyl substituent at the 3-position (geometry of the C=C bond unspecified).		2.2110cinnamyl alcoholplant metabolite
cyanidin-3-o-beta-glucopyranoside
cyanidin-3-O-beta-glucopyranoside: a natural compound distributed in several fruits & vegetables, such as strawberry, rhubarb, cherry, red cabbage, red onion, cranberries, etc.		2.1310
chitosan
[no description available]		3.1810
muramidase
Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.		2.5220
ConditionIndicatedRelationship StrengthStudiesTrials