communic-acid has been researched along with Leukemia-P388* in 1 studies
1 other study(ies) available for communic-acid and Leukemia-P388
| Article | Year |
|---|---|
First synthesis of the antifungal oidiolactone C from trans-communic acid: cytotoxic and antimicrobial activity in podolactone-related compounds.
The synthesis of the fungicide oidiolactone C starting from diterpenic trans-communic acid was carried out with an overall yield of 11.7%. The key step in the process consists of a new bislactonization reaction catalyzed by Pd(II), which gives rise to the podolactone-type tetracyclic skeleton from a norlabdadienedioic acid. We also carried out a study of the structure-biological activity of different natural podolactones and their synthetic precursors. Thus, the highest cytotoxic activity was found in dienic dilactones with ether-type substitutions on C-17, whereas the closure of the gamma-lactone ring is not critical for presenting a maximal antimicrobial activity. Topics: Animals; Antifungal Agents; Antineoplastic Agents, Phytogenic; Catalysis; Chromatography; Colonic Neoplasms; Diterpenes; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or More Rings; Humans; Inhibitory Concentration 50; Juniperus; Leukemia P388; Lung Neoplasms; Magnetic Resonance Spectroscopy; Melanoma; Mice; Molecular Structure; Oxidation-Reduction; Plants, Medicinal; Stereoisomerism; Structure-Activity Relationship; Temperature; Tumor Cells, Cultured | 2002 |