Compounds > clomesone
Page last updated: 2024-12-07

clomesone

Description

clomesone: structure & RN given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100651
CHEMBL ID290487
SCHEMBL ID6461384
MeSH IDM0122277

Synonyms (28)

Synonym
2-chloroethyl (methylsulfonyl)methanesulfonate
methanesulfonic acid, (methylsulfonyl)-, 2-chloroethyl ester
2-chloroethyl methylsulfonylmethanesulfonate
NCI60_002990
nsc-338947
88343-72-0
clomesone
nsc338947
sri 6155
(methylsulfonyl)methanesulfonic acid 2-chloroethyl ester
methanesulfonic acid, 1-(methylsulfonyl)-, 2-chloroethyl ester
nsc 338947
brn 3606917
chlorethyl soso
c4h9clo5s2
CHEMBL290487
unii-2j031w0yzi
2j031w0yzi ,
nsc-33847
SCHEMBL6461384
DTXSID10236979
2-chloro (methylsulfonyl) methanesulfonate
Z1269182185
2-chloroethyl methanesulfonylmethanesulfonate
Q27254805
EN300-253220
2-chloroethylmethanesulfonylmethanesulfonate
AKOS040758683

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Our studies suggest that O6-benzylguanine analogues may have utility in mer+ tumors as an adjuvant to a variety of alkylating agents which produce a toxic lesion at the O6 position of guanine."( Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
Dolan, ME; Mitchell, RB; Moschel, RC; Mummert, C; Pegg, AE, 1991)		0.28
"2-Chloroethyl (methylsulfonyl)methanesulfonate (ClEtSoSo) was more toxic to the BE (Mer-) cell line than to the HT-29 (Mer+) colon carcinoma."( DNA damage and cytotoxicity of 2-chloroethyl (methylsulfonyl)methanesulfonate (NSC 338947) produced in human colon carcinoma cells with or without methylating agent pretreatment.
Gibson, NW; Hartley, JA, 1986)		0.27
" The exposure to O6-alkylguanines gave a greater enhancement of the toxic effects of ClEtSoSo than of CCNU."( Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.
Dolan, ME; Pegg, AE; Young, GS, 1986)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (141)

Assay IDTitleYearJournalArticle
AID119763Mortality by day 5 expressed as number of mice died to the total treated at dose 15 mg/kg in exp4; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119777Mortality by day 5 expressed as number of mice died to the total treated at dose 33 mg/kg in exp3; 0/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119283Median survival time of the treated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID111910Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 100 mg/kg in exp2.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119268Median survival time of the treated control groups, in which there are no 30-day survivors at dose 22 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119765Mortality by day 5 expressed as number of mice died to the total treated at dose 200 mg/kg in exp1; 5/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID100656In vitro growth inhibition against L1210 murine leukemia cells1990Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
Phenyl selenones: alkyl transfer by selenium-carbon bond cleavage.
AID119782Mortality by day 5 expressed as number of mice died to the total treated at dose 50 mg/kg in exp1; 0/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229867Ratio of number of 60-day survivors to the total treated mice at dose 50 mg/kg in exp8; 2/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119265Median survival time of the treated control groups, in which there are no 30-day survivors at dose 15 mg/kg in exp41984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID111915Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 15 mg/kg in exp3.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119287Median survival time of the treated control groups, in which there are no 30-day survivors at dose 75 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119767Mortality by day 5 expressed as number of mice died to the total treated at dose 22 mg/kg in exp3; 0/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229616Ratio of median survival times for non-survivors at dose 33 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229617Ratio of median survival times for non-survivors at dose 33 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119446Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID22551Half-life after NBP alkylation1990Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
Phenyl selenones: alkyl transfer by selenium-carbon bond cleavage.
AID229826Ratio of median survival times for non-survivors at dose 75 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229852Ratio of number of 30-day survivors to the total treated mice at dose 50 mg/kg in exp7; Experiment terminatd after 30 days1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119270Median survival time of the treated control groups, in which there are no 30-day survivors at dose 22 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229602Ratio of median survival times for non-survivors at dose 15 mg/kg in exp41984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229856Ratio of number of 60-day survivors to the total treated mice at dose 100 mg/kg in exp8; 1/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID121127Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 50 mg/kg in exp1.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119291Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 100 mg/kg in exp81984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119290Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 100 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119295Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 15 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229843Ratio of number of 30-day survivors to the total treated mice at dose 100 mg/kg in exp8; 1/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119299Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 22 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119448Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229823Ratio of median survival times for non-survivors at dose 50 mg/kg in exp81984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119769Mortality by day 5 expressed as number of mice died to the total treated at dose 22 mg/kg in exp6; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119297Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 200 mg/kg in exp11984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119768Mortality by day 5 expressed as number of mice died to the total treated at dose 22 mg/kg in exp5; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229623Ratio of median survival times for non-survivors at dose 50 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229846Ratio of number of 30-day survivors to the total treated mice at dose 33 mg/kg in exp4; 1/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112065Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 50 mg/kg in exp2.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119770Mortality by day 5 expressed as number of mice died to the total treated at dose 22 mg/kg in exp7; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID111919Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 22 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID111918Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 22 mg/kg in exp3.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119750Mortality by day 5 expressed as number of mice died to the total treated at dose 100 mg/kg in exp1; 1/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229595Ratio of median survival times for non-survivors at dose 100 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119761Mortality by day 5 expressed as number of mice died to the total treated at dose 150 mg/kg in exp2; 5/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229600Ratio of median survival times for non-survivors at dose 150 mg/kg in exp2; t= toxic1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229866Ratio of number of 60-day survivors to the total treated mice at dose 50 mg/kg in exp7*-experiment terminated after 30 days1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229596Ratio of median survival times for non-survivors at dose 100 mg/kg in exp8*-toxic1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229608Ratio of median survival times for non-survivors at dose 22 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229624Ratio of median survival times for non-survivors at dose 50 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119442Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112068Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 50 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112060Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 33 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229853Ratio of number of 30-day survivors to the total treated mice at dose 50 mg/kg in exp8; 4/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119274Median survival time of the treated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119280Median survival time of the treated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229851Ratio of number of 30-day survivors to the total treated mice at dose 50 mg/kg in exp6; 3/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119776Mortality by day 5 expressed as number of mice died to the total treated at dose 33 mg/kg in exp2; 0/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119898Mortality by day 5 expressed as number of mice died to the total treated at dose 50 mg/kg in exp8; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119786Mortality by day 5 expressed as number of mice died to the total treated at dose 50 mg/kg in exp2; 0/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119762Mortality by day 5 expressed as number of mice died to the total treated at dose 15 mg/kg in exp3; 0/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119437Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229604Ratio of median survival times for non-survivors at dose 200 mg/kg in exp1; t= toxic1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229862Ratio of number of 60-day survivors to the total treated mice at dose 50 mg/kg in exp2; 0/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229619Ratio of median survival times for non-survivors at dose 33 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119300Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 22 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119788Mortality by day 5 expressed as number of mice died to the total treated at dose 50 mg/kg in exp4; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119296Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 15 mg/kg in exp41984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229618Ratio of median survival times for non-survivors at dose 33 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112067Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 50 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112057Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 33 mg/kg in exp2.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112058Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 33 mg/kg in exp3.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119443Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp11984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID111920Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 22 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119790Mortality by day 5 expressed as number of mice died to the total treated at dose 50 mg/kg in exp6; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229601Ratio of median survival times for non-survivors at dose 15 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119791Mortality by day 5 expressed as number of mice died to the total treated at dose 50 mg/kg in exp7; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119440Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229864Ratio of number of 60-day survivors to the total treated mice at dose 50 mg/kg in exp5; 1/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119754Mortality by day 5 expressed as number of mice died to the total treated at dose 100 mg/kg in exp2; 1/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229606Ratio of median survival times for non-survivors at dose 22 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119278Median survival time of the treated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119781Mortality by day 5 expressed as number of mice died to the total treated at dose 33 mg/kg in exp7; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID121125Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 100 mg/kg in exp11984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119444Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229861Ratio of number of 60-day survivors to the total treated mice at dose 50 mg/kg in exp1; 2/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112066Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 50 mg/kg in exp4.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119438Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229848Ratio of number of 30-day survivors to the total treated mice at dose 50 mg/kg in exp2; 2/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119766Mortality by day 5 expressed as number of mice died to the total treated at dose 200 mg/kg in exp8; 6/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112054Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 22 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229605Ratio of median survival times for non-survivors at dose 200 mg/kg in exp8; One death on one day 6 deaths in 27 th day and 6 deaths in 30 days survival1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119789Mortality by day 5 expressed as number of mice died to the total treated at dose 50 mg/kg in exp5; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119269Median survival time of the treated control groups, in which there are no 30-day survivors at dose 22 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID25511Pseudo first order rate constant of NBP alkylation was determined at 37 degree Centigrade1990Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
Phenyl selenones: alkyl transfer by selenium-carbon bond cleavage.
AID229860Ratio of number of 60-day survivors to the total treated mice at dose 33 mg/kg in exp4; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119756Mortality by day 5 expressed as number of mice died to the total treated at dose 100 mg/kg in exp8*-Mortality was 3/6 by day 6; 2/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119136Median survival time of the treated control groups, in which there are no 30-day survivors at dose 100 mg/kg in exp81984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119445Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp41984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112059Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 33 mg/kg in exp4.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229863Ratio of number of 60-day survivors to the total treated mice at dose 50 mg/kg in exp4; 6/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229620Ratio of median survival times for non-survivors at dose 50 mg/kg in exp11984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119134Median survival time of the treated control groups, in which there are no 30-day survivors at dose 100 mg/kg in exp11984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID121126Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 200 mg/kg in exp1.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229622Ratio of median survival times for non-survivors at dose 50 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119780Mortality by day 5 expressed as number of mice died to the total treated at dose 33 mg/kg in exp6; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119279Median survival time of the treated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp11984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119135Median survival time of the treated control groups, in which there are no 30-day survivors at dose 100 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112073Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 75 mg/kg in exp2.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229847Ratio of number of 30-day survivors to the total treated mice at dose 50 mg/kg in exp1; 4/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229625Ratio of median survival times for non-survivors at dose 50 mg/kg in exp7*-one death on 6th day, one death on 27th day & four 30 day survivors; 4/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119298Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 200 mg/kg in exp81984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119284Median survival time of the treated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp81984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119901Mortality by day 5 expressed as number of mice died to the total treated at dose 75 mg/kg in exp2; 0/51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119275Median survival time of the treated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119267Median survival time of the treated control groups, in which there are no 30-day survivors at dose 22 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119779Mortality by day 5 expressed as number of mice died to the total treated at dose 33 mg/kg in exp5; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229849Ratio of number of 30-day survivors to the total treated mice at dose 50 mg/kg in exp4; 6/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112062Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 33 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112061Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 33 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID111911Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 100 mg/kg in exp81984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112069Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 50 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229607Ratio of median survival times for non-survivors at dose 22 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229865Ratio of number of 60-day survivors to the total treated mice at dose 50 mg/kg in exp6; 1/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229615Ratio of median survival times for non-survivors at dose 33 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229850Ratio of number of 30-day survivors to the total treated mice at dose 50 mg/kg in exp5; 3/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119277Median survival time of the treated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID112070Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 50 mg/kg in exp81984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119433Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 22 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119778Mortality by day 5 expressed as number of mice died to the total treated at dose 33 mg/kg in exp4; 0/61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119434Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 22 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119447Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119449Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp81984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119441Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp61984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119264Median survival time of the treated control groups, in which there are no 30-day survivors at dose 15 mg/kg in exp31984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119439Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp41984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229592Ratio of median survival times for non-survivors at dose 100 mg/kg in exp11984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID229609Ratio of median survival times for non-survivors at dose 22 mg/kg in exp71984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119276Median survival time of the treated control groups, in which there are no 30-day survivors at dose 33 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID111916Change in weight by day 5, obtained by subtracting treated groups of animals minus control groups of animals at dose 15 mg/kg in exp4.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119451Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 75 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119282Median survival time of the treated control groups, in which there are no 30-day survivors at dose 50 mg/kg in exp51984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119294Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 150 mg/kg in exp21984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
AID119289Median survival time of the untreated control groups, in which there are no 30-day survivors at dose 100 mg/kg in exp11984Journal of medicinal chemistry, May, Volume: 27, Issue:5
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-199016 (69.57)18.7374
1990's7 (30.43)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.17 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.35%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (95.65%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
spermine
[no description available]		1.9810polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
taurine
[no description available]		1.9810amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
carmustine
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed). carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.		2.6630N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent
chlorambucil
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.		1.9710aromatic amine;
monocarboxylic acid;
nitrogen mustard;
organochlorine compound;
tertiary amino compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
lomustine
[no description available]		4.9690N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent
o(6)-benzylguanine
O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity		2.3820
temozolomide
[no description available]		1.9710imidazotetrazine;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent;
prodrug
ethylnitrosourea
Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.		4.4550N-nitrosoureasalkylating agent;
carcinogenic agent;
genotoxin;
mutagen
benzeneseleninic acid
benzeneseleninic acid: structure given in first source		1.9710
n-(2-chloroethyl)-n-nitrosoacetamide
N-(2-chloroethyl)-N-nitrosoacetamide: structure given in first source		3.0610
1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea
[no description available]		1.9810
cyclodisone
cyclodisone: structure given in first source		1.9710
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		1.9810adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
o-(6)-methylguanine
O-(6)-methylguanine: structure. 6-O-methylguanine : A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.. methylguanine : A 2-aminopurine that is guanine bearing a single methyl substituent.		2.6630methylguaninemutagen
mitozolomide
mitozolomide: RN & structure given in first source		5.3740
1-(2-chloroethyl)-1-nitrosourea
[no description available]		4.4550
n-butyl-1,3-diaminopropane
N-butyl-1,3-diaminopropane: RN given refers to parent cpd		1.9810
6-hydroxyethylguanine
6-hydroxyethylguanine: formed in DNA treated with BCNU		1.9710
s-adenosyl-1,12-diamino-3-thio-9-azadodecane
S-adenosyl-1,12-diamino-3-thio-9-azadodecane: structure given in first source		1.9810
ethoglucid
imidazole mustard: inhibitor of purine nucleoside synthesis; minor descriptor (77-84); on-line & Index Medicus search NITROGEN MUSTARD COMPOUNDS (77-84); RN given refers to parent cpd		1.9710
perfosfamide
[no description available]		1.9710
guanine
[no description available]		10.96802-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
dacarbazine
(E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.		1.9710dacarbazine
methylnitronitrosoguanidine
Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position		1.9610nitroso compoundalkylating agent
n(7)-hydroxyethylguanine
[no description available]		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.3720
Experimental Neoplasms
[description not available]		01.9710
Carcinoma, Anaplastic
[description not available]		02.6630
Cancer of Colon
[description not available]		02.6630
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.6630
Colonic Neoplasms
Tumors or cancer of the COLON.		02.6630
Experimental Mammary Neoplasms
[description not available]		01.9710
Leukemia L 1210
[description not available]		01.9610
Leucocythaemia
[description not available]		01.9710
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		01.9710
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