Page last updated: 2024-12-05

captodiamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

captodiamine: Captodiamine represents an interesting strategy for achieving benzodiazepine substitution with a low risk of dependence or impairment of cognitive function [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10240
CHEMBL ID2110809
CHEBI ID135521
SCHEMBL ID466131
MeSH IDM0479846

Synonyms (61)

Synonym
ethanamine, 2-[[[4-(butylthio)phenyl]phenylmethyl]thio]-n,n-dimethyl-
captodiamine
vufb2350
captodiamin
brn 2625367
n 68
einecs 207-629-1
captodramin
p-butylmercaptobenzhydryl-beta-dimethylamino-ethylsulphide
captodiame
covatix
2-((p-(butylthio)-alpha-phenylbenzyl)thio)-n,n-dimethylethylamine
captodiamo [inn-spanish]
captodiamum [inn-latin]
ethanamine, 2-(((4-(butylthio)phenyl)phenylmethyl)thio)-n,n-dimethyl-
ethylamine, 2-((p-(butylthio)-alpha-phenylbenzyl)thio)-n,n-dimethyl-
kaptodiamin [czech]
captodramine
captodiame [inn:ban]
covatin
captodiame (ban)
486-17-9
D07316
CHEBI:135521
2-[(4-butylsulfanylphenyl)-phenylmethyl]sulfanyl-n,n-dimethylethanamine
kaptodiamin
captodiamo
unii-h93k9455dd
captodiamum
4-06-00-06672 (beilstein handbook reference)
h93k9455dd ,
captodiame [inn]
p-butylthiodiphenylmethyl 2-dimethylaminoethyl sulfide
ethylamine, 2-((p-(butylthio)-.alpha.-phenylbenzyl)thio)-n,n-dimethyl-
2-(p-(butylthio)-.alpha.-phenylbenzylthio)-n,n-dimethylethylamine
captodiame [who-dd]
p-butylthiodiphenylmethyl 2-dimethylaminoethyl sulphide
captodiamine [mi]
butylthiodiphenylmethyl 2-dimethylaminoethyl sulfide
2-((p-(butylthio)-.alpha.-phenylbenzyl)thio)-n,n-dimethylethylamine
n-(2-([[4-(butylsulfanyl)phenyl](phenyl)methyl]sulfanyl)ethyl)-n,n-dimethylamine #
IZLPZXSZLLELBJ-UHFFFAOYSA-N
ethylamine, 2-[[p-(butylthio)-.alpha.-phenylbenzyl]thio]-n,n-dimethyl-
p-butylthiodiphenylmethyl 2-(dimethylamino)ethyl sulfide
captodiam
p-butylmercaptobenzhydryl .beta.-dimethylaminoethyl sulfide
vufb 2350
suvren (salt/mix)
p-butylmercaptobenzhydryl-.beta.-dimethylamino-ethylsulphide
SCHEMBL466131
CHEMBL2110809
2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-n,n-dimethylethanamine
DB09014
n-(2-{[[4-(butylsulfanyl)phenyl](phenyl)methyl]sulfanyl}ethyl)-n,n-dimethylamine
Q2937681
7-nitro-1,2,3,4-tetrahydro-isoquinoline hcl
DTXSID50862014
captodiamin; captodiamine; captodramin; captodramine; covatin
ethanamine, 2-(((4-(butylthio)phenyl)phenylmethyl)thio)-n,n-dimethyl- (9ci)
STARBLD0009544
AKOS040745647

Research Excerpts

Effects

ExcerptReferenceRelevance
"Captodiamine has also been found to ameliorate stress-induced anhedonia, reduce the associated elevations of hypothalamic corticotrophin-releasing factor (CRF) and restore the reductions in hypothalamic BDNF expression."( Captodiamine, a putative antidepressant, enhances hypothalamic BDNF expression in vivo by synergistic 5-HT2c receptor antagonism and sigma-1 receptor agonism.
Regan, CM; Ring, RM, 2013
)
2.55
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
diarylmethaneAny compound containing two aryl groups connected by a single C atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-199013 (76.47)18.7374
1990's0 (0.00)18.2507
2000's1 (5.88)29.6817
2010's3 (17.65)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.65 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (5.88%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (88.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]