bicyclo(3.1.0)hexane profile

Bicyclo(3.1.0)hexane, also known as norbornane, is a bicyclic hydrocarbon with a rigid, three-dimensional structure. It is a common building block in organic synthesis and has been studied extensively due to its unique properties. Synthesis: Norbornane can be synthesized via the Diels-Alder reaction between cyclopentadiene and ethylene. It is a versatile intermediate in organic synthesis and has been used in the preparation of a wide variety of natural products and pharmaceutical compounds. Effects: Due to its rigid structure, norbornane exhibits unique conformational properties that affect its reactivity and physical properties. It has been used in the development of novel materials with enhanced mechanical strength and thermal stability. Importance: Norbornane has a significant role in organic chemistry and materials science. It is a valuable building block for the synthesis of complex molecules and has been used in the development of new polymers, catalysts, and pharmaceuticals. Why it is studied: The unique structure of norbornane has attracted significant research interest. Its rigid structure, strained ring system, and versatile reactivity make it an attractive target for synthetic chemists and materials scientists.'

ID Source	ID
PubMed CID	67510
MeSH ID	M0133621

Synonym
norsabinane
bicyclo[3.1.0]hexane
bicyclo(3.1.0)hexane
285-58-5
A18573
northujane
JAPMJSVZDUYFKL-UHFFFAOYSA-N
FT-0746494
SY274842
mfcd20486282
DTXSID20951186

Excerpt	Reference	Relevance
" Compound 9 was also shown to be orally bioavailable and brain penetrable."	( Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Antal-Zimanyi, I; Chen, L; Clarke, WJ; Hogan, JB; Hu, S; Huang, Y; Iben, LG; Luo, G; Mattson, G; Poindexter, GS; Russell, JW, 2013)	0.39

Excerpt	Relevance	Reference
" Compound 9 demonstrated reduced spontaneous nocturnal food intake in a rat model when dosed ip."	( Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Antal-Zimanyi, I; Chen, L; Clarke, WJ; Hogan, JB; Hu, S; Huang, Y; Iben, LG; Luo, G; Mattson, G; Poindexter, GS; Russell, JW, 2013)	0.39

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (3.57)	18.7374
1990's	0 (0.00)	18.2507
2000's	16 (57.14)	29.6817
2010's	11 (39.29)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (6.45%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (93.55%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	2.06	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	2.04	1	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	2.01	1	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
thymidine [no description available]	2.94	4	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
uridine [no description available]	2.04	1	uridines	drug metabolite; fundamental metabolite; human metabolite
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
4-toluenesulfonic acid 4-toluenesulfonic acid: RN given refers to parent cpd; other RNs in 9th CI Form Index. toluene-4-sulfonic acid : An arenesulfonic acid that is benzenesulfonic acid in which the hydrogen at position 4 is replaced by a methyl group.	2.1	1	arenesulfonic acid; toluenes
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tert-butylhydroperoxide tert-Butylhydroperoxide: A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.. tert-butyl hydroperoxide : An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.	2.02	1	alkyl hydroperoxide	antibacterial agent; oxidising agent
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.1	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
cyclohexane Cyclohexane: C6H12. cyclohexane : An alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.	2.08	1	cycloalkane; volatile organic compound	non-polar solvent
aziridine [no description available]	2.1	1	azacycloalkane; aziridines; saturated organic heteromonocyclic parent	alkylating agent
norcarane norcarane: structure in first source	2.08	1
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	3.5	2	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
2-norbornene norbornene : A bridged compound that is cyclohexane with a methylene bridge between carbons 1 and 4 and a double bond at position 2.	3.06	1
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.48	2	metal allergen; nickel group element atom; platinum group metal atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.15	1	copper group element atom; elemental gold
alkenes [no description available]	2.44	2
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	2	1	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
carbene carbene: electrically neutral species H2C: and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons; carbene is the name of the parent hydride :CH2 ; hence, the name dichlorocarbene for :CCl2. However, names for acyclic and cyclic hydrocarbons containing one or more divalent carbon atoms are derived from the name of the corresponding all-4-hydrocarbon using the suffix -ylidene; methylene carbene also available. carbene : The electrically neutral species H2C(2.) and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons, which may be spin-paired (singlet state) or spin-non-paired (triplet state).	2	1	carbene; methanediyl
nadp [no description available]	2.08	1
deoxyribose [no description available]	2.02	1	deoxypentose	human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
phosphoramidite phosphoramidite: structure in first source. phosphoramidite : A compound with the general formula (RO)2PNR2. Phosphoramidites can be regarded as phosphites that have an NR2 instead of an OH group, or as amides of phosphorous acid.	2.02	1
ribose ribopyranose : The pyranose form of ribose.	2.44	2	D-ribose; ribopyranose
piperidines Piperidines: A family of hexahydropyridines.	2.1	1
guanosine triphosphate Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.	2.04	1	guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor

Condition	Indicated	Relationship Strength	Studies	Trials
Herpes Simplex Virus Infection [description not available]	0	2.02	1	0
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	0	2.02	1	0

bicyclo(3.1.0)hexane

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Synonyms (11)

Research Excerpts

Bioavailability

Dosage Studied

Research

Studies (28)

Market Indicators

Research Demand Index: 25.18

Study Types