B-HT 958: RN given refers to parent cpd
ID Source | ID |
---|---|
PubMed CID | 134342 |
SCHEMBL ID | 7285361 |
MeSH ID | M0109497 |
Synonym |
---|
4h-thiazolo(4,5-d)azepin-2-amine, 6-((4-chlorophenyl)methyl)-5,6,7,8-tetrahydro- |
b ht-958 |
2-amino-6-(p-chlorobenzyl)-4h-5,6,7,8-tetrahydrothiazolo(5,4-d)azepine |
b-ht 958 |
83718-64-3 |
6-[(4-chlorophenyl)methyl]-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine |
SCHEMBL7285361 |
2-amino-6-[p-chlorobenzyl]-5,6,7,8-tetrahydro-4h-thiazolo-[4,5-d]-azepine |
NCGC00386531-01 |
FT-0728316 |
BCP27640 |
b-ht 958;bht-958;bht958 |
bht 958 |
6-[(4-chlorophenyl)methyl]-3,4,5,6,7,8-hexahydro-2h-[1,3]thiazolo[4,5-d]azepin-2-imine |
DTXSID501003725 |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 37.9083 | 0.0123 | 7.9835 | 43.2770 | AID1645841 |
G | Vesicular stomatitis virus | Potency | 15.0916 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
cytochrome P450 2D6 | Homo sapiens (human) | Potency | 1.8999 | 0.0010 | 8.3798 | 61.1304 | AID1645840 |
Interferon beta | Homo sapiens (human) | Potency | 15.0916 | 0.0033 | 9.1582 | 39.8107 | AID1645842 |
HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 15.0916 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 15.0916 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 15.0916 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 10 (66.67) | 18.7374 |
1990's | 2 (13.33) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (6.67) | 24.3611 |
2020's | 2 (13.33) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 15 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Article | Year |
---|---|
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, Volume: 96, Issue: 5 | 2019 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Article | Year |
---|---|
B-HT 958, a new alpha-adrenoceptor agonist with a high pre/postsynaptic activity ratio. Naunyn-Schmiedeberg's archives of pharmacology, Volume: 320, Issue: 2 | 1982 |
B-HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors. British journal of pharmacology, Volume: 87, Issue: 2 | 1986 |
B-HT 920 and B-HT 958: presynaptic effects on electrically evoked 3H-dopamine release from slices of rat nucleus accumbens. Naunyn-Schmiedeberg's archives of pharmacology, Volume: 335, Issue: 1 | 1987 |
Sensitivity of alpha-adrenoceptor agonists to the calcium channel activator, Bay K 8644, in canine saphenous vein. Pharmacology, Volume: 35, Issue: 5 | 1987 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |