4-aminophenyl alpha-d-mannopyranoside profile

p-aminophenyl alpha-D-mannoside : An alpha-D-mannoside having 4-aminophenyl as the anomeric substituent. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	122647
CHEMBL ID	1173631
CHEBI ID	63030
SCHEMBL ID	291104
MeSH ID	M0105208

Synonym
4-aminophenyl \|a-d-mannopyranoside
(2r,3s,4s,5s,6r)-2-(4-aminophenoxy)-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
p-amph mannose
p-aminophenyl .alpha.-d-mannopyranoside
34213-86-0
.alpha.-d-mannopyranoside, 4-aminophenyl
4-aminophenyl .alpha.-d-mannopyranoside
mannopyranoside, p-aminophenyl, .alpha.-d-
p-aminophenyl mannose
4-aminophenyl .alpha.-d-mannoside
4-aminophenyl alpha-d-mannopyranoside
chebi:63030 ,
CHEMBL1173631
(2r,3s,4s,5s,6r)-2-(4-aminophenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
alpha-d-man-oc6h4nh2
4-aminophenylmannoside
alpha-d-manp-oc6h4nh2
4-aminophenyl alpha-d-mannoside
p-aminophenyl alpha-d-mannopyranoside
p-aminophenyl alpha-d-mannoside
alpha-d-mannopyranoside, 4-aminophenyl
p-aminophenyl-alpha-d-mannopyranoside
4-aminophenyl-alpha-d-mannoside
SCHEMBL291104
4-aminophenyl a-d-mannopyranoside
4-aminophenyl i+/--d-mannopyranoside
DTXSID00187800
AKOS027320453
AS-63171
4-aminophenyl alpha-d-mannopyranoside, min. 98%
(2r,3s,4s,5s,6r)-2-(4-aminophenoxy)-6-(hydroxymethyl)tetrahydro-2h-pyran-3,4,5-triol
Q27132347
4-aminophenyl ?-d-mannopyranoside
4-aminophenyl alpha -d-mannopyranoside
A875067

Class	Description
alpha-D-mannoside	Any mannoside in which the anomeric centre has alpha-configuration.
substituted aniline
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID1133344	Insulin-like activity in albino CD rat fat cells assessed as stimulation of oxidation of [14C]glucose to 14CO2 at 100 ug/ml after 2 hrs by scintillation counting analysis relative to insulin	1978	Journal of medicinal chemistry, Sep, Volume: 21, Issue:9	Structure-activity relationships of aminoalkyl and -aryl glycosides having insulin-like activity.
AID492876	Inhibition of Escherichia coli FimH-mediated hemagglutinination of guinea pig red blood cells assessed as drug level required for > 90% inhibition of hemagglutinination	2010	Journal of medicinal chemistry, Jun-24, Volume: 53, Issue:12	Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
AID1133345	Insulin-like activity in albino CD rat fat cells assessed as stimulation of oxidation of [14C]glucose to 14CO2 at 750 ug/ml after 2 hrs by scintillation counting analysis relative to insulin	1978	Journal of medicinal chemistry, Sep, Volume: 21, Issue:9	Structure-activity relationships of aminoalkyl and -aryl glycosides having insulin-like activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (14.29)	18.7374
1990's	2 (9.52)	18.2507
2000's	3 (14.29)	29.6817
2010's	13 (61.90)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
berberine [no description available]	2.21	1	alkaloid antibiotic; berberine alkaloid; botanical anti-fungal agent; organic heteropentacyclic compound	antilipemic drug; antineoplastic agent; antioxidant; EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor; EC 1.21.3.3 (reticuline oxidase) inhibitor; EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; hypoglycemic agent; metabolite; potassium channel blocker
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.13	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	2.13	1	carbohydrazide	antitubercular agent; drug allergen
mannose mannopyranose : The pyranose form of mannose.	2.68	3	D-aldohexose; D-mannose; mannopyranose	metabolite
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	2.76	3	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
transferrin Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.	2.46	2
glutathione disulfide Glutathione Disulfide: A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.	1.99	1	glutathione derivative; organic disulfide	Escherichia coli metabolite; mouse metabolite
methyl mannoside, (alpha-d)-isomer methylmannoside: RN given refers to (D)-isomer; see also record for 3-O-methylmannose. methyl alpha-D-mannoside : A methyl mannoside having alpha-configuration at the anomeric centre.	1.99	1	alpha-D-mannoside; methyl mannoside
docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.	2.11	1	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent
ly 311727 LY 311727: a potent & selective inhibitor of human non-pancreatic secretory phospholipase A2; structure given in first source	2	1
4-nitrophenyl-alpha-d-mannopyranoside 4-nitrophenyl-alpha-D-mannopyranoside: see also record for (beta)-isomer	2.05	1
glycosides [no description available]	1.97	1
acebutolol alpha-D-glucosyl-(1->4)-alpha-D-mannose : An alpha-D-glucosyl-(1->4)-D-mannopyranose in which the anomeric hydroxy group has alpha configuration.	1.99	1	alpha-D-glucosyl-(1->4)-D-mannopyranose
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	2.02	1

Condition	Relationship Strength	Studies
Rheumatoid Arthritis [description not available]	2.21	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.21	1
Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	2.21	1
Pulmonary Consumption [description not available]	2.13	1
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	2.13	1
Benign Neoplasms, Brain [description not available]	2.46	2
Glial Cell Tumors [description not available]	2.05	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.46	2
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	2.05	1

4-aminophenyl alpha-d-mannopyranoside

Description

Cross-References

Synonyms (35)

Drug Classes (2)

Bioassays (3)

Research

Studies (21)

Market Indicators

Research Demand Index: 11.73

Study Types