Compounds > 1-nitropropane
Page last updated: 2024-12-05

1-nitropropane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1-Nitropropane: A Versatile Compound with Potential Applications

1-Nitropropane is a colorless liquid with a sweet, pungent odor. It is an organic compound with the chemical formula CH3CH2CH2NO2. It belongs to the nitroalkane family, which are characterized by the presence of a nitro group (-NO2) attached to an alkyl group.

**Importance in Research:**

1-Nitropropane holds significant interest in research due to its versatile properties and potential applications in various fields:

* **Pharmaceutical Chemistry:** 1-Nitropropane has shown promise as a potential therapeutic agent. Studies suggest its possible use in treating conditions like:
* **Diabetes:** 1-Nitropropane has been observed to improve insulin sensitivity and reduce blood glucose levels in animal models.
* **Cancer:** Research indicates its potential to inhibit tumor growth and induce apoptosis in cancer cells.
* **Neurological Disorders:** Its potential to improve cognitive function and protect against neurotoxicity has also been explored.

* **Chemical Synthesis:** As a versatile building block, 1-Nitropropane is used as a starting material in the synthesis of other organic compounds. It can be converted into various derivatives, including amines, alcohols, and carboxylic acids, which find applications in diverse industries.

* **Materials Science:** 1-Nitropropane is used as a solvent and reagent in the production of various materials, such as polymers, resins, and explosives.

* **Engine Applications:** 1-Nitropropane has been explored as a potential fuel additive due to its high energy density and ability to improve combustion efficiency.

**Safety Concerns:**

While 1-Nitropropane offers promising potential, it is important to acknowledge its inherent toxicity. Exposure can lead to various adverse health effects, including:

* **Respiratory irritation**
* **Skin and eye irritation**
* **Central nervous system effects**
* **Hepatic and renal damage**

Therefore, handling and using 1-Nitropropane require strict safety protocols and proper protective measures.

**Current Research Focus:**

Current research on 1-Nitropropane primarily focuses on:

* **Understanding its mechanisms of action in various biological systems**
* **Developing safer and more efficient synthetic routes for its production**
* **Exploring its potential as a therapeutic agent for various diseases**
* **Investigating its applications in materials science and engineering**

**Conclusion:**

1-Nitropropane is a versatile compound with significant potential in various research areas. While its toxicity demands caution, ongoing research seeks to exploit its unique properties for the benefit of medicine, materials science, and other industries. Continued investigations are crucial for understanding its full potential and ensuring its safe and responsible use.

1-nitropropane : A nitroalkane that is propane substituted at C-1 by a nitro group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID7903
CHEMBL ID1449933
CHEBI ID76261
MeSH IDM0108320

Synonyms (55)

Synonym
1-nitropropane
propane, 1-nitro-
nsc6363
nsc-6363
108-03-2
wln: wn3
propane, nitro-
nitropropane
inchi=1/c3h7no2/c1-2-3-4(5)6/h2-3h2,1h
NCGC00091712-01
ccris 1329
ai3-02264
nsc 6363
hsdb 2526
einecs 203-544-9
1-nitropropane, >=98.5%
n-nitropropane
25322-01-4
N0248
A801795
NCGC00091712-02
AKOS005720804
ec 203-544-9
39w305ow99 ,
unii-39w305ow99
NCGC00256466-01
dtxsid1020980 ,
cas-108-03-2
dtxcid50980
tox21_303024
tox21_202289
NCGC00259838-01
BBL011437
STL146545
FT-0608157
1-nitropropane [inci]
nitropropane, 1-
1-nitropropane [mi]
1-nitropropane [hsdb]
3-nitropropane
CHEBI:76261 ,
1-nitro-propane
nitro-propane
CHEMBL1449933
n-c3h7no2
1-nitropan
nipar s-10
n1p ,
J-002043
1-nitropropane, analytical standard
F0001-0158
mfcd00007407
D97683
Q2567814
EN300-42942

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Differences between nitroalkanes in terms of content of nitronate tautomer at equilibrium are probably an important chemical determinant of their toxic potential."( Investigation of the chemical basis of nitroalkane toxicity: tautomerism and decomposition of propane 1- and 2-nitronate under physiological conditions.
Gescher, A; Goodwin, B; Linhart, I, 1991)		0.28

Dosage Studied

ExcerptRelevanceReference
" 1B is not appropriate, based on the fact that rat mammary and harderian tumors are likely not relevant to humans and lung and liver tumors reported in mice were equivocal in their dose-response and statistical significance."( Hazard characterization of carcinogenicity, mutagenicity, and reproductive toxicity for short chain primary nitroalkanes.
Garnick, L; Gillie, C; Kozal, J; Maier, A; Monnot, A; Quinn, J; Spencer, P, 2021)		0.62
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
primary nitroalkaneA nitroalkane in which the nitro group is attached to a terminal carbon. Major microspecies at pH 7.3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (17)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency34.93670.007215.758889.3584AID1224835
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency4.80633.189029.884159.4836AID1224846
RAR-related orphan receptor gammaMus musculus (house mouse)Potency4.24860.006038.004119,952.5996AID1159521; AID1159523
AR proteinHomo sapiens (human)Potency11.20140.000221.22318,912.5098AID1259243; AID1259247; AID743042
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency7.60540.000657.913322,387.1992AID1259377; AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency16.18440.001022.650876.6163AID1224838; AID1224839
progesterone receptorHomo sapiens (human)Potency8.47710.000417.946075.1148AID1346795
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.00790.000214.376460.0339AID588532
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency5.34870.003041.611522,387.1992AID1159552
retinoid X nuclear receptor alphaHomo sapiens (human)Potency19.13420.000817.505159.3239AID1159527
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency30.97260.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849
estrogen nuclear receptor alphaHomo sapiens (human)Potency18.68570.000229.305416,493.5996AID1259244; AID743079
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency34.37620.001723.839378.1014AID743083
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency5.39280.057821.109761.2679AID1159526
Histone H2A.xCricetulus griseus (Chinese hamster)Potency5.56020.039147.5451146.8240AID1224845
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency6.73360.001557.789015,848.9004AID1259244
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency6.73360.001551.739315,848.9004AID1259244
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (38.89)18.7374
1990's5 (27.78)18.2507
2000's3 (16.67)29.6817
2010's2 (11.11)24.3611
2020's1 (5.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 48.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index48.34 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index70.63 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (48.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (94.44%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.		1.9810amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
benzene
[no description available]		2.4420aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
1-butanol
1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.. butan-1-ol : A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.		210alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol		human metabolite;
mouse metabolite;
protic solvent
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		3.5820alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
octane
Octanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. octane : A straight chain alkane composed of 8 carbon atoms.		2.1110alkanexenobiotic
2-nitropropane
2-nitropropane: RN given refers to cpd with locant for nitro moiety in 2 position. 2-nitropropane : A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC).		3.5890secondary nitroalkanecarcinogenic agent;
hepatotoxic agent;
polar aprotic solvent;
xenobiotic
lactic acid
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.		1.97102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
pyridine
azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.		210azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines		environmental contaminant;
NMR chemical shift reference compound
baclofen
[no description available]		1.9810amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound		central nervous system depressant;
GABA agonist;
muscle relaxant
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		1.9710chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.		1.9710pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		2.0710aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
n-pentanol
n-pentanol: RN given refers to parent cpd. pentan-1-ol : A short-chain primary fatty alcohol that is pentane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It has been isolated from Melicope ptelefolia.		2.1110pentanol;
short-chain primary fatty alcohol		human metabolite;
plant metabolite
ethane
Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.		3.5820alkane;
gas molecular entity		plant metabolite;
refrigerant
propane
Propane: A three carbon alkane with the formula H3CCH2CH3.		5.34180alkane;
gas molecular entity		food propellant
nitromethane
nitromethane: structure. nitromethane : A primary nitroalkane that is methane in which one of the hydrogens is replace by a nitro group. A polar solvent (b.p. 101 degreeC), it is an important starting material in organic synthesis. It is also used as a fuel for rockets and radio-controlled models.		3.5820primary nitroalkane;
volatile organic compound		EC 4.3.1.3 (histidine ammonia-lyase) inhibitor;
explosive;
NMR chemical shift reference compound;
polar aprotic solvent
nitroethane
nitroethane : A nitroalkane that is ethane substituted by a nitro group.		3.5820primary nitroalkane
2-pentanone
pentanone : Any ketone that is pentane substituted by an oxo group at unspecified position.		2.1110methyl ketone;
pentanone		plant metabolite
hydracrylic acid
3-hydroxypropionic acid : A 3-hydroxy monocarboxylic acid that is propionic acid in which one of the hydrogens attached to the terminal carbon is replaced by a hydroxy group.		1.97103-hydroxy monocarboxylic acid;
omega-hydroxy-short-chain fatty acid		Escherichia coli metabolite;
human metabolite
n-methyl-n-2-(methylsulfinyl)ethylpropionic acid amide
N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide: structure given in first source		1.9710
thioguanine anhydrous
Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.		1.97102-aminopurinesanticoronaviral agent;
antimetabolite;
antineoplastic agent
nadp
[no description available]		2.0710
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0710cysteiniumfundamental metabolite
silicon
Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].		2.1110carbon group element atom;
metalloid atom;
nonmetal atom
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.3720
Experimental Hepatoma
[description not available]		02.3820
Abnormalities, Autosome
[description not available]		02.3720
Cancer of Liver
[description not available]		01.9710
Cancer of Skin
[description not available]		01.9710
Keratoacanthoma
A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.		01.9710
Liver Neoplasms
Tumors or cancer of the LIVER.		01.9710
Skin Neoplasms
Tumors or cancer of the SKIN.		01.9710