decussatin: a Swertia decussata xanthone; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
decussatin : A member of the class of xanthones that is xanthone substituted by a hydroxy group at position 1 and methoxy groups at positions 1, 2 and 6. It has been isolated from Centaurium erythraea and Gentiana verna. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Gentiana | genus | A plant genus of the family Gentianaceae whose members contain SECOIRIDOIDS and have been used in TRADITIONAL MEDICINE for suppressing INFLAMMATION.[MeSH] | Gentianaceae | A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH] |
| Centaurium | genus | A plant genus of the family GENTIANACEAE. Triterpene lactones and other compounds have been isolated from species of this genus. The common name of century plant has also been used for the AGAVE genus.[MeSH] | Gentianaceae | A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH] |
| Centaurium erythraea | species | [no description available] | Gentianaceae | A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 5378284 |
| CHEMBL ID | 26323 |
| CHEBI ID | 65732 |
| SCHEMBL ID | 15918485 |
| MeSH ID | M0496004 |
| Synonym |
|---|
| 1-hydroxy-3,7,8-trimethoxyxanthen-9-one |
| 8-hydroxy-1,2,6-trimethoxy-xanthen-9-one |
| bdbm50089690 |
| CHEMBL26323 , |
| chebi:65732 , |
| decussatin |
| AKOS001483007 |
| 8-hydroxy-1,2,6-trimethoxyxanthone |
| 20882-69-3 |
| xanthen-9-one, 8-hydroxy-1,2,6-trimethoxy- |
| 8-hydroxy-1,2,6-trimethoxyxanthen-9-one |
| 8-hydroxy-1,2,6-trimethoxy-9h-xanthen-9-one |
| 1-hydroxy-3,7,8-trimethoxyxanthone |
| SCHEMBL15918485 |
| 8-hydroxy-1,2,6-trimethoxy-9h-xanthen-9-one # |
| VYRIGRQQKUZPEX-UHFFFAOYSA-N |
| Q27134215 |
| DTXSID30943138 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| xanthones | Any member of the class of xanthenes based on a xanthone skeleton. |
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| phenols | Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 (µMol) | 19.0000 | 0.0000 | 2.3789 | 9.7700 | AID240726 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| biogenic amine metabolic process | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| positive regulation of signal transduction | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| dopamine catabolic process | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protein binding | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| primary amine oxidase activity | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| aliphatic amine oxidase activity | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| monoamine oxidase activity | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| flavin adenine dinucleotide binding | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| mitochondrion | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| mitochondrial outer membrane | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| cytosol | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| mitochondrion | Amine oxidase [flavin-containing] A | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID384215 | Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. |
| AID150767 | Binding affinity of compound to P-glycoprotein recombinant domain of prenylated xanthones was evaluated | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | Prenylated xanthones as potential P-glycoprotein modulators. |
| AID384216 | Antiproliferative activity against human U251 cells assessed as cell number after 48 hrs by crystal violet assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. |
| AID240726 | Concentration required to inhibit monoamine oxidase activity by 50% | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22 | QSAR modeling of the MAO inhibitory activity of xanthones derivatives. |
| AID384227 | Inhibition of bovine brain tubulin by microtubule depolymerization assay | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.70) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||