Page last updated: 2024-12-11

decussatin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

decussatin: a Swertia decussata xanthone; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

decussatin : A member of the class of xanthones that is xanthone substituted by a hydroxy group at position 1 and methoxy groups at positions 1, 2 and 6. It has been isolated from Centaurium erythraea and Gentiana verna. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Flora	Rank	Flora Definition	Family	Family Definition
Gentiana	genus	A plant genus of the family Gentianaceae whose members contain SECOIRIDOIDS and have been used in TRADITIONAL MEDICINE for suppressing INFLAMMATION.[MeSH]	Gentianaceae	A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]
Centaurium	genus	A plant genus of the family GENTIANACEAE. Triterpene lactones and other compounds have been isolated from species of this genus. The common name of century plant has also been used for the AGAVE genus.[MeSH]	Gentianaceae	A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]
Centaurium erythraea	species	[no description available]	Gentianaceae	A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]

Cross-References

ID Source	ID
PubMed CID	5378284
CHEMBL ID	26323
CHEBI ID	65732
SCHEMBL ID	15918485
MeSH ID	M0496004

Synonyms (18)

Synonym
1-hydroxy-3,7,8-trimethoxyxanthen-9-one
8-hydroxy-1,2,6-trimethoxy-xanthen-9-one
bdbm50089690
CHEMBL26323 ,
chebi:65732 ,
decussatin
AKOS001483007
8-hydroxy-1,2,6-trimethoxyxanthone
20882-69-3
xanthen-9-one, 8-hydroxy-1,2,6-trimethoxy-
8-hydroxy-1,2,6-trimethoxyxanthen-9-one
8-hydroxy-1,2,6-trimethoxy-9h-xanthen-9-one
1-hydroxy-3,7,8-trimethoxyxanthone
SCHEMBL15918485
8-hydroxy-1,2,6-trimethoxy-9h-xanthen-9-one #
VYRIGRQQKUZPEX-UHFFFAOYSA-N
Q27134215
DTXSID30943138

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

Class	Description
xanthones	Any member of the class of xanthenes based on a xanthone skeleton.
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
phenols	Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50 (µMol)	19.0000	0.0000	2.3789	9.7700	AID240726
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (3)

Process	via Protein(s)	Taxonomy
biogenic amine metabolic process	Amine oxidase [flavin-containing] A	Homo sapiens (human)
positive regulation of signal transduction	Amine oxidase [flavin-containing] A	Homo sapiens (human)
dopamine catabolic process	Amine oxidase [flavin-containing] A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Process	via Protein(s)	Taxonomy
protein binding	Amine oxidase [flavin-containing] A	Homo sapiens (human)
primary amine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
aliphatic amine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
monoamine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
flavin adenine dinucleotide binding	Amine oxidase [flavin-containing] A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Process	via Protein(s)	Taxonomy
mitochondrion	Amine oxidase [flavin-containing] A	Homo sapiens (human)
mitochondrial outer membrane	Amine oxidase [flavin-containing] A	Homo sapiens (human)
cytosol	Amine oxidase [flavin-containing] A	Homo sapiens (human)
mitochondrion	Amine oxidase [flavin-containing] A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID384215	Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID150767	Binding affinity of compound to P-glycoprotein recombinant domain of prenylated xanthones was evaluated	2000	Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12	Prenylated xanthones as potential P-glycoprotein modulators.
AID384216	Antiproliferative activity against human U251 cells assessed as cell number after 48 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID240726	Concentration required to inhibit monoamine oxidase activity by 50%	2004	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22	QSAR modeling of the MAO inhibitory activity of xanthones derivatives.
AID384227	Inhibition of bovine brain tubulin by microtubule depolymerization assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (83.33)	29.6817
2010's	1 (16.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.70 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.78 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.70)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
xanthone xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.	2.02	1	xanthones	insecticide
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	2.06	1	alkane
n-hexane hexane : An unbranched alkane containing six carbon atoms.	2.06	1	alkane; volatile organic compound	neurotoxin; non-polar solvent
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.04	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
2-Methoxyxanthone [no description available]	2.02	1	xanthones
4-methoxyxanthone 4-methoxyxanthone: a vasodilator; structure in first source	2.02	1
bellidifolin bellidifolin: isolated from Swertia japonica; structure given in first source. bellidifolin : A member of the xanthone family that is bellidin substituted with a methyl group at O-3. A natural product found particularly in Swertia chirata and Gentianella campestris.	2.43	2	polyphenol; xanthones	EC 3.1.1.7 (acetylcholinesterase) inhibitor; hypoglycemic agent; metabolite
demethylbellidifolin demethylbellidifolin: protects the myocardium against damage due to ischemia-reperfusion in rats. bellidin : A member of the class of xanthones that is xanthone which is substituted by hydroxy groups at positions 1, 3, 5, and 8. A natural product found particularly in Iris nigricans and Gentiana campestris.	2.43	2	tetrol; xanthones	antioxidant; EC 3.1.1.7 (acetylcholinesterase) inhibitor; metabolite; mutagen; radical scavenger
gentiacaulein gentiacaulein: structure in first source. gentiacaulein : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2 and 8 and methoxy groups at positions 1 and 6.	2.04	1	aromatic ether; polyphenol; xanthones	plant metabolite
gentisein gentisein: isolated from the methanol extract of the herb of Hypericum annulatum; structure in first source. gentisein : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3 and 7.	2.02	1	polyphenol; xanthones	plant metabolite
norathyriol norathyriol: from Gentinanaceae; has vasorelaxing action on rat thoracic aorta; structure given in first source. norathyriol : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.	2.02	1	polyphenol; xanthones	antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor; plant metabolite
1,2,8-trihydroxy-6-methoxyxanthone 1,2,8-trihydroxy-6-methoxyxanthone: has antidiabetic, antihyperlipidemic, and antioxidant activities; isolated from Swertia corymbosa; structure in first source. swertianin : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 2 and 8 and a methoxy group at position 6. It has been isolated from various species of the genus Swertia and has been found to exhibit antioxidant activities.	2.43	2	aromatic ether; polyphenol; xanthones	antioxidant; plant metabolite
1-hydroxyxanthone 1-hydroxyxanthone: structure in first source	2.02	1

Condition	Relationship Strength	Studies
Glial Cell Tumors [description not available]	2.04	1
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	2.04	1
Acute Promyelocytic Leukemia [description not available]	2.05	1
Leukemia, Promyelocytic, Acute An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.	2.05	1

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