Page last updated: 2024-12-06

tioxaprofen

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tioxaprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation. It is a derivative of propionic acid and is thought to work by inhibiting the production of prostaglandins. Tioxaprofen has been studied for its potential to treat a variety of conditions, including osteoarthritis, rheumatoid arthritis, and gout. It is also being investigated for its potential to treat cancer and other diseases. Tioxaprofen is available in oral and topical formulations. However, it has been withdrawn from the market in some countries due to concerns about its safety. The synthesis of tioxaprofen involves several steps, including the reaction of propionic acid with a substituted thiophenol. The resulting compound is then reacted with a suitable base to give tioxaprofen. Tioxaprofen is a potent inhibitor of cyclooxygenase, the enzyme that produces prostaglandins. Prostaglandins are involved in the inflammatory response, and their inhibition can lead to a reduction in pain and inflammation. Tioxaprofen is also a potent inhibitor of thromboxane synthase, an enzyme that is involved in platelet aggregation. This inhibition can help to reduce the risk of blood clots. While tioxaprofen is a promising drug candidate, it has been associated with a number of side effects, including gastrointestinal bleeding and liver damage. As a result, its use has been restricted in many countries. Further research is needed to evaluate the safety and efficacy of tioxaprofen.'

tioxaprofen: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72154
CHEMBL ID2106679
SCHEMBL ID35220
MeSH IDM0067155

Synonyms (27)

Synonym
40198-53-6
brn 1170622
mercaptooxazolyl carboxylic acid
tioxaprofenum [inn-latin]
einecs 254-834-7
tioxaprofene [inn-french]
emd 26644
2-((4,5-bis(p-chlorophenyl)-2-oxazolyl)thio)propionic acid
tioxaprofeno [inn-spanish]
propanoic acid, 2-((4,5-bis(4-chlorophenyl)-2-oxazolyl)thio)-
tioxaprofen
emd-26644
2-[[4,5-bis(4-chlorophenyl)-1,3-oxazol-2-yl]sulfanyl]propanoic acid
CHEMBL2106679
tioxaprofene
unii-ra6d4lw87k
tioxaprofen [inn:ban]
ra6d4lw87k ,
tioxaprofenum
tioxaprofeno
SCHEMBL35220
tioxaprofen [inn]
(+/-)-tioxaprofen
tioxaprofen, (+/-)-
Q27288029
2-{[4,5-bis(4-chlorophenyl)-1,3-oxazol-2-yl]sulfanyl}propanoic acid
DTXSID60865990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]