stellettin-b and Colonic-Neoplasms

stellettin-b has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for stellettin-b and Colonic-Neoplasms

Article	Year
Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata. Journal of natural products, 2002, Volume: 65, Issue:2 Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively. Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Philippines; Porifera; Spectrophotometry, Ultraviolet; Stereoisomerism; Triterpenes; Tumor Cells, Cultured	2002

Article

Year

Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.

Journal of natural products, 2002, Volume: 65, Issue:2

Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively.

Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Philippines; Porifera; Spectrophotometry, Ultraviolet; Stereoisomerism; Triterpenes; Tumor Cells, Cultured

2002