Compounds > geoditin a
Page last updated: 2024-11-13

geoditin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

geoditin A: isolated from the sponge Geodia japonica collected from the South China Sea; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44575708
CHEMBL ID484634
MeSH IDM0413225

Synonyms (3)

Synonym
CHEMBL484634
geoditin a
AKOS040734971
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID333743Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2004Journal of natural products, Dec, Volume: 67, Issue:12
Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID333740Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay2004Journal of natural products, Dec, Volume: 67, Issue:12
Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID1893007Antibacterial activity against Streptococcus pyogenes ATCC 12344 assessed as bacterial growth inhibition incubated for 24 hrs by microdilution assay2022Journal of natural products, 07-22, Volume: 85, Issue:7
Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge
AID333738Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2004Journal of natural products, Dec, Volume: 67, Issue:12
Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID333742Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay2004Journal of natural products, Dec, Volume: 67, Issue:12
Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID333741Cytotoxicity against human MDA-MB-423 cells after 48 hrs by MTT assay2004Journal of natural products, Dec, Volume: 67, Issue:12
Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID333739Cytotoxicity against human PC-3MIE8 cells after 48 hrs by MTT assay2004Journal of natural products, Dec, Volume: 67, Issue:12
Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
AID1893008Antibacterial activity against Staphylococcus aureus USA300 LAC assessed as bacterial growth inhibition incubated for 24 hrs by microdilution assay2022Journal of natural products, 07-22, Volume: 85, Issue:7
Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.64 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
levodopa
Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.. L-dopa : An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease		2.0710amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		2.0210alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.0510acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
ergosterol
[no description available]		2103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
stellettin b
stellettin B: from the marine sponge Rhabdastrella globostellata; structure in first source		2.7130
stellettin a
stellettin A: an isomalabaricane triterpenoid; isolated from the sponge Stelletta tenuis; structure given in first source		2.4320
cyclo(leucyl-prolyl)
cyclo(leucyl-prolyl): structure in first source. cyclo(L-Leu-L-Pro) : A homodetic cyclic peptide composed from leucyl and prolyl residues.		210dipeptide;
homodetic cyclic peptide;
pyrrolopyrazine		bacterial metabolite;
marine metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Adenocarcinoma, Basal Cell
[description not available]		02.0510
Cancer of Colon
[description not available]		02.0510
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.0510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0510
Malignant Melanoma
[description not available]		02.0710
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.0710