Assay ID | Title | Year | Journal | Article |
AID1570878 | Induction of read through activity at premature termination codon TAA (non-sense mutation associated with DMD disease) in 27-mer DNA stretch sequence of mouse dystrophin mdx gene transfected as a plasmid by connecting with beta-galactosidase and luciferas | 2019 | ACS medicinal chemistry letters, Oct-10, Volume: 10, Issue:10
| New Negamycin-Based Potent Readthrough Derivative Effective against TGA-Type Nonsense Mutations. |
AID1570877 | Induction of read through activity at premature termination codon TAG (non-sense mutation associated with DMD disease) in 27-mer DNA stretch sequence of mouse dystrophin mdx gene transfected as a plasmid by connecting with beta-galactosidase and luciferas | 2019 | ACS medicinal chemistry letters, Oct-10, Volume: 10, Issue:10
| New Negamycin-Based Potent Readthrough Derivative Effective against TGA-Type Nonsense Mutations. |
AID68192 | In vitro antibacterial activity against Enterobacter cloacae ATCC 35030 | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID96252 | In vitro antibacterial activity against Klebsiella pneumoniae ATCC 113882 | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID70906 | In vitro antibacterial activity against Escherichia coli MG1655 tolC | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID210224 | In vitro antibacterial activity against Streptococcus pneumoniae VSPN1005 | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID130536 | In vivo efficacy in Escherichia coli murine septicemia model | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID70905 | In vitro antibacterial activity against Escherichia coli MG1655 | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID206140 | In vitro antibacterial activity against Staphylococcus aureus ATCC 25293 | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID1230793 | Mutation read through activity in african green monkey COS7 cells transfected with dual-reporter plasmid encoding beta-galactosidase and luciferase genes connected with TGA-containing mouse mdx gene exon 23 nucleotide sequence as premature termination cod | 2015 | ACS medicinal chemistry letters, Jun-11, Volume: 6, Issue:6
| Structure-Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates. |
AID1503964 | Mutation read through activity at premature termination codon TGA-containing mouse dystrophin gene exon 23 nucleotide sequence expressed in African green monkey COS7 cells assessed as ratio of luciferase activity to beta-galactosidase activity at 200 uM a | 2017 | ACS medicinal chemistry letters, Oct-12, Volume: 8, Issue:10
| Structure-Activity Relationship Study of Leucyl-3- |
AID1570876 | Induction of read through activity at premature termination codon TGA (non-sense mutation associated with DMD disease) in 27-mer DNA stretch sequence of mouse dystrophin mdx gene transfected as a plasmid by connecting with beta-galactosidase and luciferas | 2019 | ACS medicinal chemistry letters, Oct-10, Volume: 10, Issue:10
| New Negamycin-Based Potent Readthrough Derivative Effective against TGA-Type Nonsense Mutations. |
AID1250082 | Inhibition of transcription-translation process in Escherichia coli | 2015 | ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8
| Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens. |
AID1250085 | Antibacterial activity against Escherichia coli ATCC 25922 | 2015 | ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8
| Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens. |
AID69133 | Inhibitory activity against protein synthesis of Escherichia coli S30 by cell-free transcription/translation coupled assay | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID70904 | In vitro antibacterial activity against Escherichia coli ATCC 25922 | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID165053 | In vitro antibacterial activity against Pseudomonas aeruginosa PA013 | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| N- and C-terminal modifications of negamycin. |
AID1586840 | Induction of read through activity at cricket paralysis virus-internal ribosome entry site codon UGG assessed as increase in octapeptide formation from FKVRQ-tRNAGln at EC50 to 2 times EC50 measured after 20 mins in presence of Typ-tRNA, Leu-tRNA and [35S | 2018 | ACS medicinal chemistry letters, Dec-13, Volume: 9, Issue:12
| New |
AID1250088 | Antibacterial activity against mexABCDXY-deficient Pseudomonas aeruginosa PAO1 | 2015 | ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8
| Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens. |
AID1250086 | Antibacterial activity against Pseudomonas aeruginosa PAO1 | 2015 | ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8
| Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens. |
AID1250083 | Antibacterial activity against Acinetobacter baumannii ARC 3495 | 2015 | ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8
| Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens. |
AID114652 | Compound was evaluated for its efficacy in an Escherichia coli murine septicemia model | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
| Conformationally restricted analogs of deoxynegamycin. |
AID1250084 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 | 2015 | ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8
| Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens. |
AID1250087 | Antibacterial activity against tolC-deficient Escherichia coli ATCC 25922 | 2015 | ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8
| Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens. |
AID1586839 | Induction of read through activity at cricket paralysis virus-internal ribosome entry site premature termination codon UGA assessed as ratio of plateau octapeptide to FKVRQ-tRNAGln measured after 20 mins in presence of Typ-tRNA, Leu-tRNA and [35S]-Met-tRN | 2018 | ACS medicinal chemistry letters, Dec-13, Volume: 9, Issue:12
| New |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |