n-hydroxyacetaminophen has been researched along with acetaminophen in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (92.86) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Calder, IC; Ham, KN; Hart, SJ; Healey, K | 1 |
| Gemborys, MW; Gribble, GW; Mudge, GH | 2 |
| Calder, I; Hayward, NK; Lavin, MF | 1 |
| Djordjevic, SP; Hayward, NK; Lavin, MF | 1 |
| Dahlin, DC; Dybing, E; Holme, JA; Nelson, SD | 1 |
| Dybing, E; Thorgeirsson, SS; von Bahr, C; Wirth, PJ | 1 |
| Dybing, E; Holme, JA; Thorgeirsson, SS; Wirth, PJ | 2 |
| Calder, IC; Hart, SJ; Healey, K; Smail, MC | 1 |
| Corcoran, GB; Mitchell, JR | 1 |
| Gillette, JR; Hinson, JA; Pohl, LR | 1 |
| Corcoran, GB; Horning, EC; Mitchell, JR; Vaishnav, YN | 1 |
| Holme, JA; Hongslo, JK; Rannug, U; Srám, R | 1 |
1 review(s) available for n-hydroxyacetaminophen and acetaminophen
| Article | Year |
|---|---|
International Commission for Protection against Environmental Mutagens and Carcinogens. An evaluation of the genetic toxicity of paracetamol.
Topics: Acetaminophen; Acetates; Acetic Acid; Adult; Aminophenols; Animals; Bacteria; Benzoquinones; Biotransformation; Cell Line; Child; Chromosomes; DNA Damage; DNA Repair; DNA Replication; Female; Humans; Imines; Mutagenicity Tests; Plants; Rats; Rats, Sprague-Dawley; Ribonucleotide Reductases; Rodentia | 1995 |
13 other study(ies) available for n-hydroxyacetaminophen and acetaminophen
| Article | Year |
|---|---|
N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen.
Topics: Acetaminophen; Animals; Biotransformation; Kinetics; Mathematics; Mice; Rats | 1981 |
Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen.
Topics: Acetaminophen; Half-Life; Hydrogen-Ion Concentration; Hydroxylation; Kinetics | 1980 |
Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate.
Topics: Acetaminophen; Drug Stability; Half-Life; Hydrogen-Ion Concentration; Sulfates; Temperature | 1978 |
Effect of N-hydroxyparacetamol on DNA, RNA, and protein synthesis and chromatin structure.
Topics: Acetaminophen; Cell Survival; Cells, Cultured; Chromatin; DNA; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Protein Biosynthesis; RNA | 1986 |
Effect of N-hydroxyparacetamol on cell cycle progression.
Topics: Acetaminophen; Animals; Cell Cycle; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Flow Cytometry; Hydrogen-Ion Concentration; Kidney; Nucleic Acid Conformation; Rats; Time Factors | 1986 |
Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol.
Topics: Acetaminophen; Animals; Benzoquinones; Dose-Response Relationship, Drug; Glutathione; Imines; In Vitro Techniques; Lipid Peroxides; Liver; Male; Rats; Rats, Inbred Strains | 1984 |
Mechanism of N-hydroxyacetylarylamine mutagenicity in the Salmonella test system: metabolic activation of N-hydroxyphenacetin by liver and kidney fractions from rat, mouse, hamster, and man.
Topics: Acetaminophen; Animals; Ascorbic Acid; Biotransformation; Cricetinae; Humans; Kidney; Kinetics; Liver; Male; Mice; Mutagenicity Tests; Mutagens; Paraoxon; Phenacetin; Rats; Salmonella typhimurium; Species Specificity | 1980 |
Cytotoxic effects of N-hydroxyparacetamol in suspsensions of isolated rat hepatocytes.
Topics: Acetaminophen; Animals; Cell Membrane; Glutathione; In Vitro Techniques; Lipid Peroxides; Liver; Male; Protein Binding; Rats; Rats, Inbred Strains | 1982 |
Modulation of N-hydroxyparacetamol cytotoxicity in suspensions of isolated rat hepatocytes.
Topics: Acetaminophen; Animals; Cell Survival; Drug Stability; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Lipid Peroxides; Liver; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1982 |
3-thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Female; Rats; Rats, Inbred Strains | 1982 |
Evidence for redox cycling of acetaminophen and its reactive metabolite by endogenous microsomal systems.
Topics: Acetaminophen; Animals; Biotransformation; Carbon Radioisotopes; Gas Chromatography-Mass Spectrometry; Male; Mice; Microsomes, Liver; Oxidation-Reduction; Tritium | 1981 |
A simple high-pressure liquid chromatographic assay for the N-hydroxy derivatives of phenacetin, acetaminophen, 2-acetylaminofluorene, and other hydroxamic acids.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cricetinae; Hydroxamic Acids; Hydroxyacetylaminofluorene; Male; Mesocricetus; Microsomes, Liver; Phenacetin; Spectrophotometry; Structure-Activity Relationship | 1980 |
Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.
Topics: Acetaminophen; Animals; Ascorbic Acid; Benzoquinones; Cysteine; Imines; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Rats | 1980 |