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n-hydroxyacetaminophen and acetaminophen

n-hydroxyacetaminophen has been researched along with acetaminophen in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-199013 (92.86)18.7374
1990's1 (7.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Calder, IC; Ham, KN; Hart, SJ; Healey, K1
Gemborys, MW; Gribble, GW; Mudge, GH2
Calder, I; Hayward, NK; Lavin, MF1
Djordjevic, SP; Hayward, NK; Lavin, MF1
Dahlin, DC; Dybing, E; Holme, JA; Nelson, SD1
Dybing, E; Thorgeirsson, SS; von Bahr, C; Wirth, PJ1
Dybing, E; Holme, JA; Thorgeirsson, SS; Wirth, PJ2
Calder, IC; Hart, SJ; Healey, K; Smail, MC1
Corcoran, GB; Mitchell, JR1
Gillette, JR; Hinson, JA; Pohl, LR1
Corcoran, GB; Horning, EC; Mitchell, JR; Vaishnav, YN1
Holme, JA; Hongslo, JK; Rannug, U; Srám, R1

Reviews

1 review(s) available for n-hydroxyacetaminophen and acetaminophen

ArticleYear
International Commission for Protection against Environmental Mutagens and Carcinogens. An evaluation of the genetic toxicity of paracetamol.
    Mutation research, 1995, Volume: 327, Issue:1-2

    Topics: Acetaminophen; Acetates; Acetic Acid; Adult; Aminophenols; Animals; Bacteria; Benzoquinones; Biotransformation; Cell Line; Child; Chromosomes; DNA Damage; DNA Repair; DNA Replication; Female; Humans; Imines; Mutagenicity Tests; Plants; Rats; Rats, Sprague-Dawley; Ribonucleotide Reductases; Rodentia

1995

Other Studies

13 other study(ies) available for n-hydroxyacetaminophen and acetaminophen

ArticleYear
N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:8

    Topics: Acetaminophen; Animals; Biotransformation; Kinetics; Mathematics; Mice; Rats

1981
Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:3

    Topics: Acetaminophen; Half-Life; Hydrogen-Ion Concentration; Hydroxylation; Kinetics

1980
Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:7

    Topics: Acetaminophen; Drug Stability; Half-Life; Hydrogen-Ion Concentration; Sulfates; Temperature

1978
Effect of N-hydroxyparacetamol on DNA, RNA, and protein synthesis and chromatin structure.
    Molecular pharmacology, 1986, Volume: 29, Issue:5

    Topics: Acetaminophen; Cell Survival; Cells, Cultured; Chromatin; DNA; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Protein Biosynthesis; RNA

1986
Effect of N-hydroxyparacetamol on cell cycle progression.
    Biochemical pharmacology, 1986, Oct-15, Volume: 35, Issue:20

    Topics: Acetaminophen; Animals; Cell Cycle; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Flow Cytometry; Hydrogen-Ion Concentration; Kidney; Nucleic Acid Conformation; Rats; Time Factors

1986
Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol.
    Biochemical pharmacology, 1984, Feb-01, Volume: 33, Issue:3

    Topics: Acetaminophen; Animals; Benzoquinones; Dose-Response Relationship, Drug; Glutathione; Imines; In Vitro Techniques; Lipid Peroxides; Liver; Male; Rats; Rats, Inbred Strains

1984
Mechanism of N-hydroxyacetylarylamine mutagenicity in the Salmonella test system: metabolic activation of N-hydroxyphenacetin by liver and kidney fractions from rat, mouse, hamster, and man.
    Molecular pharmacology, 1980, Volume: 18, Issue:1

    Topics: Acetaminophen; Animals; Ascorbic Acid; Biotransformation; Cricetinae; Humans; Kidney; Kinetics; Liver; Male; Mice; Mutagenicity Tests; Mutagens; Paraoxon; Phenacetin; Rats; Salmonella typhimurium; Species Specificity

1980
Cytotoxic effects of N-hydroxyparacetamol in suspsensions of isolated rat hepatocytes.
    Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:2

    Topics: Acetaminophen; Animals; Cell Membrane; Glutathione; In Vitro Techniques; Lipid Peroxides; Liver; Male; Protein Binding; Rats; Rats, Inbred Strains

1982
Modulation of N-hydroxyparacetamol cytotoxicity in suspensions of isolated rat hepatocytes.
    Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:2

    Topics: Acetaminophen; Animals; Cell Survival; Drug Stability; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Lipid Peroxides; Liver; Rats; Rats, Inbred Strains; Sulfhydryl Compounds

1982
3-thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol.
    Xenobiotica; the fate of foreign compounds in biological systems, 1982, Volume: 12, Issue:6

    Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Female; Rats; Rats, Inbred Strains

1982
Evidence for redox cycling of acetaminophen and its reactive metabolite by endogenous microsomal systems.
    Advances in experimental medicine and biology, 1981, Volume: 136 Pt B

    Topics: Acetaminophen; Animals; Biotransformation; Carbon Radioisotopes; Gas Chromatography-Mass Spectrometry; Male; Mice; Microsomes, Liver; Oxidation-Reduction; Tritium

1981
A simple high-pressure liquid chromatographic assay for the N-hydroxy derivatives of phenacetin, acetaminophen, 2-acetylaminofluorene, and other hydroxamic acids.
    Analytical biochemistry, 1980, Jan-15, Volume: 101, Issue:2

    Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cricetinae; Hydroxamic Acids; Hydroxyacetylaminofluorene; Male; Mesocricetus; Microsomes, Liver; Phenacetin; Spectrophotometry; Structure-Activity Relationship

1980
Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.
    Molecular pharmacology, 1980, Volume: 18, Issue:3

    Topics: Acetaminophen; Animals; Ascorbic Acid; Benzoquinones; Cysteine; Imines; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Rats

1980