miserotoxin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

miserotoxin: toxin from Emory milkvetch; measured by nitro moiety [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

miserotoxin : A beta-D-glucoside having 3-nitropropyl as the anomeric alkyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	107795
CHEBI ID	6951
MeSH ID	M0074873

Synonyms (16)

Synonym
glucopyranoside, 3-nitropropyl-, beta-d-
3-nitropropyl-beta-d-glucopyranoside
3-nitropropyl beta-d-glucopyranoside
3-nitro-1-propyl-beta-d-glucoside
beta-d-glucopyranoside, 3-nitropropyl-
CHEBI:6951
C08507
24502-76-9
miserotoxin
(2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-(3-nitropropoxy)oxane-3,4,5-triol
0j55bw984l ,
unii-0j55bw984l
.beta.-d-glucopyranoside, 3-nitropropyl
Q27107373
DTXSID50947395
3-nitropropyl hexopyranoside

Research Excerpts

Overview

Miserotoxin is a causative agent in cattle poisoning when timber milkvetch (Astragalus miser) is consumed.

Excerpt	Reference	Relevance
"Miserotoxin is a causative agent in cattle poisoning when timber milkvetch (Astragalus miser) is consumed."	( Excretion of miserotoxin and detoxification of the aglycone by grasshoppers (Orthoptera: Acrididae). Benn, MH; Johnson, DL; Majak, W, 2001)	1.4

Dosage Studied

Excerpt	Relevance	Reference
" (Leguminosae), was rapidly hydrolyzed to 3-nitropropanol (NPOH) in the rumen of cattle dosed with timber milkvetch (A."	( Absorption of 3-nitropropanol (miserotoxin aglycone) from the compound stomach of cattle. Majak, W; Muir, AD; Pass, MA; Rode, LM, 1984)	0.55

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
phytotoxin	Any toxin produced by a plant.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
C-nitro compound	A nitro compound having the nitro group (-NO2) attached to a carbon atom.
beta-D-glucoside	Any D-glucoside in which the anomeric centre has beta-configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (44.44)	18.7374
1990's	1 (11.11)	18.2507
2000's	4 (44.44)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.96 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.36 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.96)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (10.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycine [no description available]	2	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	3.48	2	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
oxalic acid Oxalic Acid: A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.. oxalic acid : An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.	3.06	1	alpha,omega-dicarboxylic acid	algal metabolite; human metabolite; plant metabolite
1-propanol 1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.. propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.	2.38	2	propan-1-ols; short-chain primary fatty alcohol	metabolite; protic solvent
3-nitropropionic acid 3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE. 3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.	2.9	4	C-nitro compound	antimycobacterial drug; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor; mycotoxin; neurotoxin
edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.	1.96	1	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	3.06	1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
skatole [no description available]	3.06	1	methylindole	human metabolite; mammalian metabolite
dimethyl disulfide [no description available]	3.06	1	organic disulfide	xenobiotic metabolite
3-nitro-1-propanol 3-nitro-1-propanol: RN given refers to parent cpd; N1 same as NM. 3-nitropropan-1-ol : The nitro compound formed from propan-1-ol by nitration at C-3.	2.67	3	C-nitro compound
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	4.69	9	D-glucopyranose	epitope; mouse metabolite
cobalt-ethylenediamine tetraacetic acid chelate cobalt-ethylenediamine tetraacetic acid chelate: RN given refers to parent cpd; synonym dicobalt edetate refers to di-Na salt	1.96	1
glycosides [no description available]	2.65	3
7-deoxy-13-dihydroadriamycinone 7-deoxy-13-dihydroadriamycinone: a metabolite of epidoxorubicin	2	1
oxalates Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.	3.06	1

Condition	Relationship Strength	Studies
Adenocarcinoma, Basal Cell [description not available]	2.02	1
Cancer of Cervix [description not available]	2.02	1
Sterility, Female [description not available]	2.02	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.02	1
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	2.02	1
Infertility, Female Diminished or absent ability of a female to achieve conception.	2.02	1
Bovine Diseases [description not available]	3.28	2
Edema, Pulmonary [description not available]	2.88	1
Centriacinar Emphysema [description not available]	2.88	1
Pulmonary Edema Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	2.88	1
Plant Poisoning Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.	1.95	1
Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	1.95	1
Ovine Diseases [description not available]	1.95	1

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