Compounds > 3-nitro-1-propanol
Page last updated: 2024-12-06

3-nitro-1-propanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-nitro-1-propanol: RN given refers to parent cpd; N1 same as NM [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

3-nitropropan-1-ol : The nitro compound formed from propan-1-ol by nitration at C-3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID32832
CHEBI ID49042
SCHEMBL ID437912
MeSH IDM0082820

Synonyms (28)

Synonym
brn 1746958
einecs 246-716-9
1-propanol, 3-nitro-
3-nitropropanol
25182-84-7
3-nitropropan-1-ol
3-nitro-1-propanol
CHEBI:49042
FT-0692250
3-nitro-propan-1-ol
AKOS006228877
3-01-00-01429 (beilstein handbook reference)
unii-9284xw200i
9284xw200i ,
3-nitro propanol
SCHEMBL437912
3-hydroxy-1-nitropropane
DTXSID10179852
mfcd00040626
BCP20936
3-nitro-1-propano;3-nitro-1-propanol;1-propanol, 3-nitro-
SY211657
CS-0209456
Q27121449
A12344
AS-57333
A904039
EN300-311971

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"The nitrocompounds 3-nitropropanol (NPOH) and 3-nitropropionic acid (NPA) were shown to be equally toxic when injected intraperitoneally into male Wistar rats."( Effect of alcohol and aldehyde dehydrogenase inhibitors on the toxicity of 3-nitropropanol in rats.
Majak, W; Muir, AD; Pass, MA; Yost, GS, 1985)		0.27
" It is hoped that by summarizing existing knowledge, an understanding of the activities and toxicological profiles of newly established nitrocompounds might be anticipated or adverse events associated with their use might be avoided."( Toxicity and metabolism of nitroalkanes and substituted nitroalkanes.
Anderson, RC; Smith, DJ, 2013)		0.39

Dosage Studied

ExcerptRelevanceReference
" (Leguminosae), was rapidly hydrolyzed to 3-nitropropanol (NPOH) in the rumen of cattle dosed with timber milkvetch (A."( Absorption of 3-nitropropanol (miserotoxin aglycone) from the compound stomach of cattle.
Majak, W; Muir, AD; Pass, MA; Rode, LM, 1984)		0.27
" Plasma levels of NPA and inorganic nitrite were higher after dosing with NPOH than with NPA indicating a more rapid rate of uptake of the aglycone."( Absorption of 3-nitropropanol and 3-nitropropionic acid from the digestive system of sheep.
Majak, W; Muir, AD; Pass, MA; Yost, GS, 1984)		0.27
" In animals dosed with NPOH, the observed NPA decayed at a slower rate than NPOH."( Conversion of 3-nitropropanol (miserotoxin aglycone) to 3-nitropropionic acid in cattle and sheep.
Majak, W; Muir, AD; Pass, MA; Yost, GS, 1984)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
C-nitro compoundA nitro compound having the nitro group (-NO2) attached to a carbon atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (61.11)18.7374
1990's2 (11.11)18.2507
2000's2 (11.11)29.6817
2010's3 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.75 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.75 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (10.53%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (89.47%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formic acid
formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.		2.110monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
lactic acid
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.		2.1102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.4220elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
nitrates
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.		1.9910monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		2.8740monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
1-propanol
1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.. propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.		8.91130propan-1-ols;
short-chain primary fatty alcohol		metabolite;
protic solvent
3-nitropropionic acid
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE. 3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.		5.67150C-nitro compoundantimycobacterial drug;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mycotoxin;
neurotoxin
fomepizole
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.. fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.		1.9610pyrazolesantidote;
EC 1.1.1.1 (alcohol dehydrogenase) inhibitor;
protective agent
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		1.9610ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
ethane
Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.		1.9610alkane;
gas molecular entity		plant metabolite;
refrigerant
nitroethane
nitroethane : A nitroalkane that is ethane substituted by a nitro group.		1.9610primary nitroalkane
acrolein
[no description available]		6.9610enalherbicide;
human xenobiotic metabolite;
toxin
ditiocarb
Ditiocarb: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.. diethyldithiocarbamic acid : A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.		1.9610dithiocarbamic acidschelator;
copper chelator
ferrous sulfate
ferrous sulfate: Ferro-Gradumet is ferrous sulfate in controlled release form; RN given refers to Fe(+2)[1:1] salt. iron(2+) sulfate (anhydrous) : A compound of iron and sulfate in which the ratio of iron(2+) to sulfate ions is 1:1. Various hydrates occur naturally - most commonly the heptahydrate, which loses water to form the tetrahydrate at 57degreeC and the monohydrate at 65degreeC.		1.9810iron molecular entity;
metal sulfate		reducing agent
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.6730D-glucopyranoseepitope;
mouse metabolite
cobalt-ethylenediamine tetraacetic acid chelate
cobalt-ethylenediamine tetraacetic acid chelate: RN given refers to parent cpd; synonym dicobalt edetate refers to di-Na salt		1.9610
miserotoxin
miserotoxin: toxin from Emory milkvetch; measured by nitro moiety. miserotoxin : A beta-D-glucoside having 3-nitropropyl as the anomeric alkyl group.		2.6730beta-D-glucoside;
C-nitro compound		phytotoxin
sodium sulfide
sodium sulfide: see also record for sodium bisulfide; actisoufre is the sodium sulfide component of sulfur-containing thermal springs which is also found in Saccharomyces cerevisiae		1.9810
glycosides
[no description available]		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Bovine Diseases
[description not available]		01.9510
Plant Poisoning
Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.		01.9510
Ovine Diseases
[description not available]		01.9510