Page last updated: 2024-11-13
millepachine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
millepachine: isolated from Millettia pachycarpa Benth (Leguminosae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
Flora | Rank | Flora Definition | Family | Family Definition |
---|---|---|---|---|
Millettia | genus | A plant genus of the family FABACEAE. Members contain ISOFLAVONES, some of which show molluscicidal and schistosomicidal activity. Some species of Pongamia have been reclassified to this genus and some to DERRIS.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
Millettia pachycarpa | species | [no description available] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
Cross-References
ID Source | ID |
---|---|
PubMed CID | 66573474 |
CHEMBL ID | 2041121 |
SCHEMBL ID | 16697964 |
SCHEMBL ID | 16697961 |
MeSH ID | M0587529 |
Synonyms (14)
Synonym |
---|
CHEMBL2041121 |
millepachine |
SCHEMBL16697964 |
SCHEMBL16697961 |
HY-N7591 |
CS-0134506 |
E75119 |
1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one |
1579976-20-7 |
(e)-1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one |
(e)-1-(5-methoxy-2,2-dimethylchromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one |
MS-25411 |
1393922-01-4 |
AKOS040756722 |
Research Excerpts
Overview
Millepachine (MIL) is a bioactive natural product that shows great potential for cancer treatment.
Excerpt | Reference | Relevance |
---|---|---|
"Millepachine (MIL) is a bioactive natural product that shows great potential for cancer treatment. " | ( The effect and mechanism of millepachine-disrupted spindle assembly in tumor cells. Gong, Y; Liu, F; Liu, Y; Su, A; Wu, W; Ye, H; Zhao, W; Zhu, J, 2018) | 2.22 |
Bioavailability
Excerpt | Reference | Relevance |
---|---|---|
" Furthermore, the hydrochloride salt of 8 (8·HCl) significantly improved the bioavailability up to 47% while retaining the antiproliferative activity." | ( Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. Cao, D; Chen, L; Li, L; Liu, L; Ma, L; Tang, M; Wang, F; Wang, G; Wang, J; Wen, J; Wu, W; Xiang, M; Xiang, W; Yang, J; Yang, Z; You, J; Zhang, R; Zhu, J, 2014) | 0.66 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (39)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID733797 | Cytotoxicity against human LO2 cells by MTT assay | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents. |
AID1905035 | Antiproliferative activity against human A2780 cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
AID667443 | Antiproliferative activity against human SKOV3 cells after 24 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID733798 | Cytotoxicity against human A375 cells by MTT assay | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents. |
AID667446 | Antiproliferative activity against human SW620 cells after 24 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1474394 | Cytotoxicity against human T24 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. |
AID667452 | Cell cycle arrest in human HepG2 cells assessed as accumulation at G1 phase at 2.5 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.86%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID667456 | Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 5 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 32.43%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID733800 | Cytotoxicity against human HepG2 cells by MTT assay | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents. |
AID1130047 | Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Apr-01, Volume: 22, Issue:7 | Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents. |
AID1604238 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Recent advances in α,β-unsaturated carbonyl compounds as mitochondrial toxins. |
AID667457 | Cell cycle arrest in human HepG2 cells assessed as accumulation at G2/M phase at 5 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 17.72%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1474391 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. |
AID667445 | Antiproliferative activity against human HT-29 cells after 24 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1905036 | Antiproliferative activity against human HCT-8 cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
AID1905034 | Antiproliferative activity against human HeLa cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
AID1905033 | Antiproliferative activity against human A549 cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
AID733799 | Cytotoxicity against human K562 cells by MTT assay | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents. |
AID667458 | Antitumor activity against human A549 cells xenografted in BALB/c mouse assessed as tumor growth inhibition at 20 mg/kg, iv administered at intervals of 2 days for 18 days relative to control | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1474392 | Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. |
AID1474393 | Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. |
AID1905037 | Antiproliferative activity against human MCF7 cells assessed as cell viability incubated for 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6 | Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. |
AID667442 | Antiproliferative activity against human K562 cells after 24 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID667447 | Inhibition of alpha-tubulin in human HepG2 cells assessed as decrease in microtubule formation at 1 uM after 24 hrs by DAPI staining-based immunofluorescence analysis | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1474390 | Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. |
AID667448 | Inhibition of alpha-tubulin in human HepG2 cells assessed as decrease in spindle formation at 1 uM after 24 hrs by DAPI staining-based immunofluorescence analysis | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID667441 | Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1163570 | Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19 | Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. |
AID667449 | Cell cycle arrest in human HepG2 cells assessed as accumulation at G1 phase at 1.25 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.86%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1163571 | Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19 | Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. |
AID667444 | Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1474395 | Cytotoxicity against human HL7702 cells after 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. |
AID667455 | Cell cycle arrest in human HepG2 cells assessed as accumulation at G1 phase at 5 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 49.86%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID667451 | Cell cycle arrest in human HepG2 cells assessed as accumulation at G2/M phase at 1.25 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 17.72%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID667454 | Cell cycle arrest in human HepG2 cells assessed as accumulation at G2/M phase at 2.5 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 17.72%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID1163569 | Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19 | Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors. |
AID667459 | Toxicity in BALB/c mouse bearing human A549 cells assessed as decrease in body weight at 20 mg/kg, iv administered at intervals of 2 days for 18 days | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID667450 | Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 1.25 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 32.43%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
AID667453 | Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 2.5 uM after 8 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 32.43%) | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (18)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 14 (77.78) | 24.3611 |
2020's | 4 (22.22) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.63
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.63) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 2 (11.11%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 16 (88.89%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |