Page last updated: 2024-12-08

schaftoside

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

schaftoside: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

schaftoside : A C-glycosyl compound that is apigenin substituted by beta-D-glucopyranosyl and an alpha-L-arabinopyranosyl moieties at positions 6 and 8 via C-glycosidic linkages. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID182689
MeSH IDM0504289

Synonyms (6)

Synonym
51938-32-0
schaftoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2r,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-[(2s,3r,4s,5s)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one
4h-1-benzopyran-4-one, 8alpha-l-arabinopyranosyl-6beta-d-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-
S9234
CCG-270071

Research Excerpts

Overview

Schaftoside (SS) is a bioactive compound of Herba Desmodii Styracifolii. The herb has traditionally been used to treat hepatitis and cholelithiasis.

ExcerptReferenceRelevance
"Schaftoside is a flavone-C-glycoside isolated from Herba Desmodii Styracifolii with valuable anti-kidney stones efficacies. "( Comparative metabolism of schaftoside in healthy and calcium oxalate kidney stone rats by UHPLC-Q-TOF-MS/MS method.
Liu, R; Liu, Y; Lv, T; Ma, H; Meng, C; Wang, C; Xie, S; Zhang, Z, 2020
)
2.3
"Schaftoside (SS) is a bioactive compound of Herba Desmodii Styracifolii, which has traditionally been used to treat hepatitis and cholelithiasis."( Schaftoside alleviates HFD-induced hepatic lipid accumulation in mice via upregulating farnesoid X receptor.
Cai, W; Liu, C; Liu, M; Mi, S; Song, M; Wang, J; Wu, S; Zhang, G, 2020
)
2.72
"Schaftoside (SS) is a bioactive compound present in the Herba Desmodii Styracifolii (DS), a herb that has been used to treat cholelithiasis and urolithiasis in Chinese medicine. "( Prevention of cholesterol gallstone disease by schaftoside in lithogenic diet-induced C57BL/6 mouse model.
Chen, H; Huang, X; Liu, C; Liu, M; Mi, S; Zeng, X; Zhou, J, 2017
)
2.15

Pharmacokinetics

ExcerptReferenceRelevance
"The novel integrated double peak pharmacokinetic approach to studying the holistic pharmacokinetic properties of traditional Chinese medicine has been successfully developed and validated using AM as a model drug."( Integrated pharmacokinetics and biodistribution of multiple flavonoid C-glycosides components in rat after oral administration of Abrus mollis extract and correlations with bio-effects.
Gu, N; Huo, M; Jiang, Z; Wang, H; Xiong, F; Yan, C; Zheng, C, 2015
)
0.42
" The method was applied to a pharmacokinetic study of Abrus cantoniensis Hance in rats."( Simultaneous determination of abrine, hypaphorine, schaftoside and soyasaponin Bb in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Abrus cantoniensis Hance extract.
Bu, Q; Huang, B; Li, C; Liu, C; Lu, P; Zhang, C, 2023
)
1.16

Compound-Compound Interactions

ExcerptReferenceRelevance
") Merr has been established, based on analysis of high-performance liquid chromatography fingerprint combined with the similarity analysis (SA), hierarchical cluster analysis (HCA), principal component analysis (PCA), discriminant analysis (DA) and the quantitative analysis multi-components by single marker (QAMS) method."( Quantitative and Chemical Fingerprint Analysis of Desmodium styracifolium by High-Performance Liquid Chromatography Combined with Chemometrics.
Chen, L; Cheng, X; Tang, X; Yang, Q, 2020
)
0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (50.00)24.3611
2020's8 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.59 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index5.86 (4.65)
Search Engine Demand Index39.34 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]