Page last updated: 2024-12-10

11-deoxyprostaglandin e1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

11-deoxyprostaglandin E1: RN given refers to (13E,15S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5283055
CHEMBL ID3246389
CHEBI ID176744
SCHEMBL ID1056605
MeSH IDM0105113

Synonyms (33)

Synonym
7-[(1r,2r)-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
CHEBI:176744
gtpl1925
doproston
11-deoxyprostaglandin e1
doprostone
prost-13-en-1-oic acid, 15-hydroxy-9-oxo-, (13e,15s)-
11-deoxy-pge1
11-deoxy-prostaglandin e1
9-oxo-15s-hydroxy-13e-prostaenoic acid
LMFA03010054
ay-23578
11-deoxy pge-1
PDSP2_001670
37786-00-8
unii-ug6237d2ho
ug6237d2ho ,
11-deoxy prostaglandin e1
doproston b
9-oxo-15s-hydroxy-prost-13e-en-1-oic acid
CHEMBL3246389
SCHEMBL1056605
HMS3648B09
AKOS032429044
Q27070753
SR-01000946400-1
sr-01000946400
STL565649
(13e,15s)-15-hydroxy-9-oxoprost-13-en-1-oic acid
11-deoxy-pge1.
11-deoxy pge1
DTXSID101317623
PD021209
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
prostanoidThe family of natural prostaglandins and prostaglandin-like compounds including prostacyclins and thromboxanes.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID1131938Bronchodilatory activity in iv dosed Hartley guinea pig assessed as inhibition of serotonin-induced spasm administered 3 to 4 times at 15 mins interval starting 2 mins post challenge1977Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
Prostaglandins and congeners. 15. Synthesis and bronchodilator activity of dl-11-deoxy-15- or 16-alkylprostaglandins.
AID1131939Bronchodilatory activity in iv dosed Hartley guinea pig assessed as inhibition of histamine-induced spasm administered 3 to 4 times at 15 mins interval starting 2 mins post challenge1977Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
Prostaglandins and congeners. 15. Synthesis and bronchodilator activity of dl-11-deoxy-15- or 16-alkylprostaglandins.
AID1131940Bronchodilatory activity in iv dosed Hartley guinea pig assessed as inhibition of acetylcholine-induced spasm administered 3 to 4 times at 15 mins interval starting 2 mins post challenge1977Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
Prostaglandins and congeners. 15. Synthesis and bronchodilator activity of dl-11-deoxy-15- or 16-alkylprostaglandins.
AID1346307Mouse EP4 receptor (Prostanoid receptors)1997British journal of pharmacology, Sep, Volume: 122, Issue:2
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
AID1346427Human EP4 receptor (Prostanoid receptors)2009The Journal of pharmacology and experimental therapeutics, Oct, Volume: 331, Issue:1
Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.
AID1346318Rat EP2 receptor (Prostanoid receptors)1997European journal of pharmacology, Dec-11, Volume: 340, Issue:2-3
Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes.
AID1346427Human EP4 receptor (Prostanoid receptors)2000British journal of pharmacology, Aug, Volume: 130, Issue:8
Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor.
AID1346303Mouse EP2 receptor (Prostanoid receptors)1997British journal of pharmacology, Sep, Volume: 122, Issue:2
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
AID1346396Rat EP3 receptor (Prostanoid receptors)1997European journal of pharmacology, Dec-11, Volume: 340, Issue:2-3
Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes.
AID1346336Mouse EP3 receptor (Prostanoid receptors)1997British journal of pharmacology, Sep, Volume: 122, Issue:2
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (38)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (15.79)18.7374
1990's19 (50.00)18.2507
2000's11 (28.95)29.6817
2010's2 (5.26)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.79 (24.57)
Research Supply Index3.91 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other49 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]