19-hydroxyprostaglandin-e1 and Infertility--Male

19-hydroxyprostaglandin-e1 has been researched along with Infertility--Male* in 2 studies

Other Studies

2 other study(ies) available for 19-hydroxyprostaglandin-e1 and Infertility--Male

Article	Year
Immunosuppression by seminal plasma from fertile and infertile men: inhibition of natural killer cell function correlates with seminal PG concentration. Prostaglandins, leukotrienes, and essential fatty acids, 1991, Volume: 42, Issue:4 Human seminal plasma has uniquely high concentrations of PGE and 19-hydroxy PGE but the function of these PGs has not been elucidated. PGs of the E series have been shown to be paracrine and autocrine regulators of the function of immune cells and high levels of PGE have been shown consistently to suppress function in such cells. Human seminal plasma has a potent immunosuppressive effect and evidence is accumulating that this is largely due to PG components. In this study the effects of human seminal plasma on the killing activity of natural killer (NK) cells as judged by 51Cr release from K562 cells have been studied in groups of fertile and infertile men. Although there was no significant difference in the PGE, 19-hydroxy PGE or the NK cell inhibitory activity in the two groups, the inhibition of NK cell activity was closely correlated with the PGE and the 19-OH PGE content of the seminal plasma in the fertile group. This finding is further evidence that the major contribution to the immunosuppressive properties of human semen is provide by the high concentration of PGs of the E series in this fluid. Topics: Alprostadil; Cell Line; Cytotoxicity, Immunologic; Fertility; Humans; Immune Tolerance; Infertility, Male; Killer Cells, Natural; Male; Prostaglandins E; Radioimmunoassay; Reference Values; Semen	1991
19-Hydroxy-prostaglandin E and infertility in human males. Prostaglandins and medicine, 1979, Volume: 2, Issue:5 We measured the content of 19-hydroxy-prostaglandin E (19-OH-PGE) and prostaglandin E (PGE) in the semen of 10 infertile males by alkaline dehydration, thin layer chromatographic separation and ultraviolet spectrophotometry. 7 fertile males were also studied. In both groups the content of seminal 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) also was measured by thin layer chromatographic separation and highly specific radioimmunoassay. The amounts of 19-OH-PGE and PGE were significantly lower (p < .02, p < .05) in the infertile group than the fertile group. Differences in mean seminal 6-keto-F1 alpha were not significant. The uterine stimulatory actions of 19-OH-PGE demonstrable in the monkey may apply to fertility in man. Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Chromatography, Thin Layer; Humans; Infertility, Male; Male; Prostaglandins E; Prostaglandins F; Semen; Sperm Count	1979

Article

Year

Immunosuppression by seminal plasma from fertile and infertile men: inhibition of natural killer cell function correlates with seminal PG concentration.

Prostaglandins, leukotrienes, and essential fatty acids, 1991, Volume: 42, Issue:4

Human seminal plasma has uniquely high concentrations of PGE and 19-hydroxy PGE but the function of these PGs has not been elucidated. PGs of the E series have been shown to be paracrine and autocrine regulators of the function of immune cells and high levels of PGE have been shown consistently to suppress function in such cells. Human seminal plasma has a potent immunosuppressive effect and evidence is accumulating that this is largely due to PG components. In this study the effects of human seminal plasma on the killing activity of natural killer (NK) cells as judged by 51Cr release from K562 cells have been studied in groups of fertile and infertile men. Although there was no significant difference in the PGE, 19-hydroxy PGE or the NK cell inhibitory activity in the two groups, the inhibition of NK cell activity was closely correlated with the PGE and the 19-OH PGE content of the seminal plasma in the fertile group. This finding is further evidence that the major contribution to the immunosuppressive properties of human semen is provide by the high concentration of PGs of the E series in this fluid.

Topics: Alprostadil; Cell Line; Cytotoxicity, Immunologic; Fertility; Humans; Immune Tolerance; Infertility, Male; Killer Cells, Natural; Male; Prostaglandins E; Radioimmunoassay; Reference Values; Semen

1991

19-Hydroxy-prostaglandin E and infertility in human males.

Prostaglandins and medicine, 1979, Volume: 2, Issue:5

We measured the content of 19-hydroxy-prostaglandin E (19-OH-PGE) and prostaglandin E (PGE) in the semen of 10 infertile males by alkaline dehydration, thin layer chromatographic separation and ultraviolet spectrophotometry. 7 fertile males were also studied. In both groups the content of seminal 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) also was measured by thin layer chromatographic separation and highly specific radioimmunoassay. The amounts of 19-OH-PGE and PGE were significantly lower (p < .02, p < .05) in the infertile group than the fertile group. Differences in mean seminal 6-keto-F1 alpha were not significant. The uterine stimulatory actions of 19-OH-PGE demonstrable in the monkey may apply to fertility in man.

Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Chromatography, Thin Layer; Humans; Infertility, Male; Male; Prostaglandins E; Prostaglandins F; Semen; Sperm Count

1979