Page last updated: 2024-12-08

uk 34787

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

UK 34787: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID194468
CHEMBL ID284356
SCHEMBL ID11346119
MeSH IDM0093389

Synonyms (24)

Synonym
nsc342229
nsc-342229
72818-36-1
uk-34787
uk 34787
CHEMBL284356 ,
bdbm50022121
3-imidazol-1-ylmethyl-2-isopropyl-1h-indole(uk-34787)
3-imidazol-1-ylmethyl-2-isopropyl-1h-indole
3-(imidazol-1-ylmethyl)-2-propan-2-yl-1h-indole
1h-indole, 3-(1h-imidazol-1-ylmethyl)-2-(1-methylethyl)-
nsc 342229
xr92sxl6ze ,
3-isopropyl-3-(1-imidazolylmethyl)indole
unii-xr92sxl6ze
DTXSID00223136
3-(imidazol-1-ylmethyl)-2-isopropylindole
NZXGMVRYQLENHC-UHFFFAOYSA-N
SCHEMBL11346119
AKOS030539398
3-((1h-imidazol-1-yl)methyl)-2-isopropyl-1h-indole
PD181421
3-(1h-imidazol-1-ylmethyl)-2-(1-methylethyl)-1h-indole
3-[(1h-imidazol-1-yl)methyl]-2-(propan-2-yl)-1h-indole
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 11B1, mitochondrialRattus norvegicus (Norway rat)IC50 (µMol)2.00000.49503.52895.0000AID3095
Thromboxane-A synthase Homo sapiens (human)IC50 (µMol)0.01500.00091.230410.0000AID212779; AID215773
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (18)

Processvia Protein(s)Taxonomy
prostaglandin biosynthetic processThromboxane-A synthase Homo sapiens (human)
icosanoid metabolic processThromboxane-A synthase Homo sapiens (human)
cyclooxygenase pathwayThromboxane-A synthase Homo sapiens (human)
intracellular chloride ion homeostasisThromboxane-A synthase Homo sapiens (human)
response to ethanolThromboxane-A synthase Homo sapiens (human)
positive regulation of vasoconstrictionThromboxane-A synthase Homo sapiens (human)
response to fatty acidThromboxane-A synthase Homo sapiens (human)
prostaglandin biosynthetic processProstacyclin synthaseHomo sapiens (human)
icosanoid metabolic processProstacyclin synthaseHomo sapiens (human)
cyclooxygenase pathwayProstacyclin synthaseHomo sapiens (human)
negative regulation of NF-kappaB transcription factor activityProstacyclin synthaseHomo sapiens (human)
NAD biosynthesis via nicotinamide riboside salvage pathwayProstacyclin synthaseHomo sapiens (human)
positive regulation of peroxisome proliferator activated receptor signaling pathwayProstacyclin synthaseHomo sapiens (human)
negative regulation of nitric oxide biosynthetic processProstacyclin synthaseHomo sapiens (human)
positive regulation of angiogenesisProstacyclin synthaseHomo sapiens (human)
negative regulation of inflammatory responseProstacyclin synthaseHomo sapiens (human)
cellular response to interleukin-1Prostacyclin synthaseHomo sapiens (human)
cellular response to interleukin-6Prostacyclin synthaseHomo sapiens (human)
cellular response to hypoxiaProstacyclin synthaseHomo sapiens (human)
apoptotic signaling pathwayProstacyclin synthaseHomo sapiens (human)
positive regulation of execution phase of apoptosisProstacyclin synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Processvia Protein(s)Taxonomy
monooxygenase activityThromboxane-A synthase Homo sapiens (human)
thromboxane-A synthase activityThromboxane-A synthase Homo sapiens (human)
iron ion bindingThromboxane-A synthase Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenThromboxane-A synthase Homo sapiens (human)
heme bindingThromboxane-A synthase Homo sapiens (human)
12-hydroxyheptadecatrienoic acid synthase activityThromboxane-A synthase Homo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activityThromboxane-A synthase Homo sapiens (human)
monooxygenase activityProstacyclin synthaseHomo sapiens (human)
iron ion bindingProstacyclin synthaseHomo sapiens (human)
protein bindingProstacyclin synthaseHomo sapiens (human)
prostaglandin-I synthase activityProstacyclin synthaseHomo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenProstacyclin synthaseHomo sapiens (human)
heme bindingProstacyclin synthaseHomo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activityProstacyclin synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
endoplasmic reticulumThromboxane-A synthase Homo sapiens (human)
endoplasmic reticulum membraneThromboxane-A synthase Homo sapiens (human)
cytosolThromboxane-A synthase Homo sapiens (human)
extracellular spaceProstacyclin synthaseHomo sapiens (human)
nucleusProstacyclin synthaseHomo sapiens (human)
endoplasmic reticulumProstacyclin synthaseHomo sapiens (human)
endoplasmic reticulum membraneProstacyclin synthaseHomo sapiens (human)
caveolaProstacyclin synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID212779Inhibitory activity against thromboxane A2 synthetase1985Journal of medicinal chemistry, Oct, Volume: 28, Issue:10
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.
AID155523Inhibition of PGI-2 synthetase from porcine aorta1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.
AID161164Inhibition of Prostaglandin G/H synthase from ram seminal vesicle microsomes1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.
AID215773Inhibition of TXA2 synthetase from human platelets1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.
AID161184Inhibition of ram seminal vesicle Cyclooxygenase1985Journal of medicinal chemistry, Oct, Volume: 28, Issue:10
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.
AID3095Inhibition of rat adrenal 11-beta-hydroxylase1985Journal of medicinal chemistry, Oct, Volume: 28, Issue:10
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.
AID155526Inhibition of porcine aorta prostacyclin PGI-2 synthase by bioassay method1985Journal of medicinal chemistry, Oct, Volume: 28, Issue:10
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.
AID3093Inhibition of 11 beta-hydroxylase from rat adrenal gland1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.37 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]