| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
adenine
[no description available] | 2.68 | 3 | 0 | 6-aminopurines;
purine nucleobase | Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
thymine
[no description available] | 2 | 1 | 0 | pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives. | 9.13 | 39 | 2 | isourea;
monocarboxylic acid amide;
one-carbon compound | Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
bisbenzimidazole
Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis. | 3.1 | 1 | 0 | bibenzimidazole;
N-methylpiperazine | anthelminthic drug;
fluorochrome |
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group. | 1.98 | 1 | 0 | aromatic ether;
nitrile;
polyether;
tertiary amino compound | |
stallimycin
[no description available] | 3.1 | 1 | 0 | | |
netropsin
Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research. | 3.1 | 1 | 0 | | |
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. | 2 | 1 | 0 | mitomycin | alkylating agent;
antineoplastic agent |
benzimidazole
1H-benzimidazole : The 1H-tautomer of benzimidazole. | 3.1 | 1 | 0 | benzimidazole;
polycyclic heteroarene | |
xanthenes
Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring. | 3.1 | 1 | 0 | xanthene | |
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen. | 2.7 | 3 | 0 | pyrrole;
secondary amine | |
sodium hydroxide
Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed) | 1.98 | 1 | 0 | alkali metal hydroxide | |
propamidine
propamidine: structure given in first source. propamidine : A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis. | 3.1 | 1 | 0 | aromatic ether;
guanidines;
polyether | antimicrobial agent;
antiseptic drug |
tallimustine
tallimustine: structure given in first source | 3.52 | 2 | 0 | | |
1,7-phenanthroline
[no description available] | 1.97 | 1 | 0 | phenanthroline | |
lexitropsin
lexitropsin: structure given in first source; information reading oligopeptide | 3.1 | 1 | 0 | | |
psorospermin
psorospermin: from Psorospermum febrifugum (Clusiaceae); some evidence it alkylates Gua N7 of DNA. psorospermin : An organic heterotetracyclic compound that is 1,2-dihydro-6H-furo[2,3-c]xanthene substituted by a hydroxy group at position 10, a methoxy group at position 5 nad a 2-methyloxiran-2-yl group at position 2. | 3.1 | 1 | 0 | epoxide;
organic heterotetracyclic compound;
xanthones | antineoplastic agent;
plant metabolite |
n-(5-(2,3-dihydrobenzofuryl)sulfonyl)-n'-(3,4-dichlorophenyl)urea
N-(5-(2,3-dihydrobenzofuryl)sulfonyl)-N'-(3,4-dichlorophenyl)urea: a second generation diarylsulfonylurea; structure given in first source | 3.09 | 1 | 0 | | |
bis(1,10-phenanthroline)copper(2+) ion
bis(1,10-phenanthroline)copper(2+) ion: RN given refers to (Cu+2) cation | 1.97 | 1 | 0 | | |
irofulven
irofulven: structure in first source | 3.09 | 1 | 0 | cyclohexenones | |
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent. | 1.97 | 1 | 0 | oxygen hydride;
oxygen radical;
reactive oxygen species | |
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring. | 5.55 | 13 | 0 | | |
adozelesin
[no description available] | 4.96 | 12 | 0 | | |
sjg 136
1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione): structure in first source | 2.02 | 1 | 0 | | |
melphalan
Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring. | 2.02 | 1 | 0 | L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound | alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent |
sesquiterpenes
[no description available] | 3.09 | 1 | 0 | | |
carzelesin
carzelesin: a cyclopropylpyrroloindole analog of U 73975; longer lasting than U 77779; structure in first source | 2.69 | 3 | 0 | | |
pnu 151807
[no description available] | 2.02 | 1 | 0 | | |
cc 1065
CC 1065: from Streptomyces zelensis; structure in second sourc | 5.1 | 8 | 0 | | |
pluramycin
[no description available] | 1.99 | 1 | 0 | | |
oligonucleotides
[no description available] | 1.97 | 1 | 0 | | |
chromomycins
Chromomycins: A complex of several closely related glycosidic antibiotics from Streptomyces griseus. The major component, CHROMOMYCIN A3, is used as a fluorescent stain of DNA where it attaches and inhibits RNA synthesis. It is also used as an antineoplastic agent, especially for solid tumors.. chromomycin : A family of antibiotics isolated from Streptomyces griseus. | 3.1 | 1 | 0 | | |