Page last updated: 2024-08-24

u 77779 and urea

u 77779 has been researched along with urea in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	22 (56.41)	18.2507
2000's	16 (41.03)	29.6817
2010's	1 (2.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baker, RM; Beerman, TA; Meegan, RL; Woynarowski, JM; Zsido, TJ	1
Ding, ZM; Hurley, LH	1
Gibson, NW; Lee, CS	3
Abraham, I; Adams, EG; Bhuyan, BK; Butryn, RK; Sampson, KE; Smith, KS; Stackpole, J	1
Beerman, TA; Gawron, LS; McHugh, MM; Woynarowski, JM	1
Hurley, LH; Thompson, AS	1
Fan, JY; Hansen, M; Hurley, LH; Sun, D; Thompson, AS	1
Ames, MM; Reid, JM; Walker, DL	1
Gibson, NW; Lee, CS; Pfeifer, GP	1
Hurley, L; Seaman, FC	1
Angioli, R; Averette, H; Hightower, RD; Nguyen, H; Perras, J; Sevin, BU; Untch, M	1
Han, FX; Hurley, LH	1
Flora, KP; Garg, A; Grieshaber, CK; Murphy, MJ; Parchment, RE; Tomaszewski, JE; Volpe, DA	1
Beerman, TA; Woynarowski, JM	1
Von Hoff, DD	1
Carter, CA; DeKoning, TF; Li, LH; McGovren, JP; Plowman, J; Waud, WR	1
Ebisu, H; Fukuda, Y; Furuta, H; Kusama, Y; Oomori, Y; Terashima, S	1
Chapman, WG; Herzig, MC; Napier, C; Woynarowski, JM	1
Cerna, C; Gomez, L; Hidalgo, M; Izbicka, E; Rowinsky, EK; Von Hoff, DD; Weitman, SD	1
Beerman, TA; Kuo, SR; Liu, JS; McHugh, MM; Melendy, T; Walsh-O'Beirne, MH	1
Arnett, B; Napier, C; Trevino, AV; Woynarowski, JM	1
Koba, M; Konopa, J; Skladanowski, A	1
Lown, JW; Reddy, BS; Sharma, SK	1
Gao, X; Han, X	1
Ebisu, H; Fukuda, Y; Furuta, H; Oomori, Y; Seto, S; Terashima, S	1
Benham, CJ; Hardies, SC; Rodriguez, KA; Trevino, AV; Woynarowski, JM	1
Arnett, B; Dziegielewski, J; Herzig, MC; Hurley, L; Rodriguez, KA; Trevino, AV; Woynarowski, JM	1
Adjei, AA; Ames, MM; Atherton, P; Bagniewski, PG; Erlichman, C; Goldberg, RM; Pitot, HC; Rayson, D; Reid, JM; Rubin, J; Sloan, JA	1
Woynarowski, JM	1
Berg, K; Hammond, LA; Patnaik, A; Rizzo, J; Rowinsky, EK; Schwartz, GH; Von Hoff, DD	1
Beerman, T; Cao, PR; McHugh, MM; Melendy, T	1
Herman, TS; Herzig, MC; Jackson, JA; Trevino, AV; Woynarowski, JM	1
Bai, S; Goodrich, DW	1
Alley, MC; Gregson, SJ; Hartley, JA; Hollingshead, MG; Howard, PW; Pacula-Cox, CM; Sausville, EA; Thurston, DE; Waud, WR	1
Denny, WA; Ferguson, LR; Nelson, SM	1
Ginsburg, H; Krugliak, M; Woynarowski, JM	1
Coppens, I; Kumar, N; Mlambo, G	1

Reviews

4 review(s) available for u 77779 and urea

Article	Year
Promising new agents for treatment of patients with colorectal cancer. Seminars in oncology, 1998, Volume: 25, Issue:5 Suppl 11 Topics: Adenoviridae; Antineoplastic Agents; Benzofurans; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Duocarmycins; Enzyme Inhibitors; Humans; Indoles; Phenylurea Compounds; Sesquiterpenes; Thymidylate Synthase; Tumor Cells, Cultured; Urea	1998
Recent developments in sequence selective minor groove DNA effectors. Current medicinal chemistry, 2001, Volume: 8, Issue:5 Topics: Animals; Anthraquinones; Benzimidazoles; Bisbenzimidazole; Bleomycin; Chemistry, Pharmaceutical; Cross-Linking Reagents; Distamycins; DNA; Drug Design; Duocarmycins; Humans; Indoles; Leucomycins; Ligands; Netropsin; Urea	2001
Sequence specific recognition of ligand-DNA complexes studied by NMR. Current medicinal chemistry, 2001, Volume: 8, Issue:5 Topics: Antineoplastic Agents; Benzamidines; Binding Sites; Bleomycin; Chromomycins; DNA; DNA Adducts; Drug Design; Duocarmycins; Indoles; Intercalating Agents; Leucomycins; Ligands; Magnetic Resonance Spectroscopy; Metals; Molecular Structure; Platinum Compounds; Signal Processing, Computer-Assisted; Urea; Xanthenes; Xanthones	2001
Targeting critical regions in genomic DNA with AT-specific anticancer drugs. Biochimica et biophysica acta, 2002, Jul-18, Volume: 1587, Issue:2-3 Topics: Antineoplastic Agents; Base Sequence; Benzofurans; Binding Sites; Cyclohexanecarboxylic Acids; Cyclohexenes; Distamycins; DNA Damage; DNA, Neoplasm; Drug Design; Duocarmycins; Genome, Human; Humans; Indoles; Nitrogen Mustard Compounds; Tandem Repeat Sequences; Tumor Cells, Cultured; Urea	2002

Trials

2 trial(s) available for u 77779 and urea

Article	Year
A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:3 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Biological Availability; Duocarmycins; Female; Humans; Indoles; Injections, Intravenous; Leukocyte Count; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutrophils; Urea	2002
A phase I study of bizelesin, a highly potent and selective DNA-interactive agent, in patients with advanced solid malignancies. Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Duocarmycins; Female; Humans; Indoles; Intercalating Agents; Male; Middle Aged; Neoplasms; Urea	2003

Article

Year

A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:3

Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Biological Availability; Duocarmycins; Female; Humans; Indoles; Injections, Intravenous; Leukocyte Count; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutrophils; Urea

2002

A phase I study of bizelesin, a highly potent and selective DNA-interactive agent, in patients with advanced solid malignancies.

Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:5

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Duocarmycins; Female; Humans; Indoles; Intercalating Agents; Male; Middle Aged; Neoplasms; Urea

2003

Other Studies

33 other study(ies) available for u 77779 and urea

Article	Year
Resistance of CHO cells expressing P-glycoprotein to cyclopropylpyrroloindole (CPI) alkylating agents. Biochemical pharmacology, 1992, Apr-15, Volume: 43, Issue:8 Topics: Alkylating Agents; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzofurans; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; Drug Resistance; Duocarmycins; Indoles; Leucomycins; Membrane Glycoproteins; Urea	1992
DNA interstrand cross-linking, DNA sequence specificity, and induced conformational changes produced by a dimeric analog of (+)-CC-1065. Anti-cancer drug design, 1991, Volume: 6, Issue:5 Topics: Adenine; Antibiotics, Antineoplastic; Base Sequence; Copper; Cross-Linking Reagents; DNA; DNA Damage; DNA Fingerprinting; Duocarmycins; Electrophoresis; Hydroxides; Hydroxyl Radical; Indoles; Leucomycins; Molecular Sequence Data; Nucleic Acid Conformation; Oligonucleotides; Phenanthrolines; Structure-Activity Relationship; Urea	1991
DNA damage and differential cytotoxicity produced in human carcinoma cells by CC-1065 analogues, U-73,975 and U-77,779. Cancer research, 1991, Dec-15, Volume: 51, Issue:24 Topics: Antibiotics, Antineoplastic; Benzofurans; Carcinoma; Cell Death; Colonic Neoplasms; Cross-Linking Reagents; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; Dose-Response Relationship, Drug; Duocarmycins; Humans; Indoles; Leucomycins; Lung Neoplasms; Plasmids; Tumor Cells, Cultured; Urea	1991
V79 Chinese hamster lung cells resistant to the bis-alkylator bizelesin are multidrug-resistant. Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:1 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Blotting, Northern; Cell Division; Cell Line; Cell Survival; Cricetinae; Cricetulus; Drug Resistance; Duocarmycins; Fibroblasts; Genotype; Humans; Indoles; Lung; Mice; Phenotype; RNA; Tumor Cells, Cultured; Urea; Verapamil	1994
Effects of bizelesin (U-77779), a bifunctional alkylating minor groove agent, on genomic and simian virus 40 DNA. Biochemistry, 1995, Oct-10, Volume: 34, Issue:40 Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Cross-Linking Reagents; DNA Adducts; DNA Damage; DNA Primers; DNA, Viral; Duocarmycins; In Vitro Techniques; Indoles; Molecular Sequence Data; Mutagens; Nucleic Acid Conformation; Simian virus 40; Urea	1995
Solution conformation of a bizelesin A-tract duplex adduct: DNA-DNA cross-linking of an A-tract straightens out bent DNA. Journal of molecular biology, 1995, Sep-08, Volume: 252, Issue:1 Topics: Adenine; Base Sequence; Cross-Linking Reagents; DNA Adducts; Duocarmycins; Hydrogen Bonding; Indoles; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Solutions; Urea	1995
Determination of the structural role of the internal guanine-cytosine base pair in recognition of a seven-base-pair sequence cross-linked by bizelesin. Biochemistry, 1995, Sep-05, Volume: 34, Issue:35 Topics: Alkylation; Base Composition; Base Sequence; Binding Sites; Cross-Linking Reagents; DNA; DNA Adducts; Duocarmycins; In Vitro Techniques; Indoles; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Molecular Structure; Thermodynamics; Urea	1995
Preclinical pharmacology of bizelesin, a potent bifunctional analog of the DNA-binding antibiotic CC-1065. Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:4 Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Cyclohexenes; Duocarmycins; Indoles; Leucomycins; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Urea	1994
Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. Biochemistry, 1994, May-17, Volume: 33, Issue:19 Topics: Alkylating Agents; Base Sequence; Benzofurans; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA; Duocarmycins; Genes, p53; Humans; Indoles; Molecular Sequence Data; Phosphoglycerate Kinase; Polymerase Chain Reaction; Tumor Cells, Cultured; Urea	1994
Interstrand cross-linking by bizelesin produces a Watson-Crick to Hoogsteen base-pairing transition region in d(CGTAATTACG)2. Biochemistry, 1993, Nov-30, Volume: 32, Issue:47 Topics: Base Sequence; Cross-Linking Reagents; DNA; Duocarmycins; Hydrogen Bonding; Indoles; Isomerism; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Polydeoxyribonucleotides; Protons; Urea	1993
DNA interstrand cross-links induced by the cyclopropylpyrroloindole antitumor agent bizelesin are reversible upon exposure to alkali. Biochemistry, 1993, Sep-07, Volume: 32, Issue:35 Topics: Antineoplastic Agents; Base Sequence; Cross-Linking Reagents; DNA Damage; Duocarmycins; Hydrogen-Ion Concentration; Indoles; Models, Chemical; Molecular Sequence Data; Oligodeoxyribonucleotides; Sodium Hydroxide; Urea	1993
Nucleotide preferences for DNA interstrand cross-linking induced by the cyclopropylpyrroloindole analogue U-77,779. Biochemistry, 1993, Mar-16, Volume: 32, Issue:10 Topics: Alkylation; Antineoplastic Agents; Base Sequence; Cross-Linking Reagents; DNA; Duocarmycins; Electrophoresis, Polyacrylamide Gel; Indoles; Intercalating Agents; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Structure-Activity Relationship; Urea	1993
In vitro evaluation of the novel chemotherapeutic agents U-73,975, U-77,779, and U-80,244 in gynecologic cancer cell lines. Cancer investigation, 1993, Volume: 11, Issue:3 Topics: Adenosine Triphosphate; Antineoplastic Agents; Benzofurans; Cisplatin; Cyclohexanecarboxylic Acids; Cyclohexenes; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; Duocarmycins; Endometrial Neoplasms; Female; Humans; In Vitro Techniques; Indoles; Ovarian Neoplasms; Tumor Cells, Cultured; Urea; Uterine Cervical Neoplasms	1993
A model for the T-antigen-induced structural alteration of the SV40 replication origin based upon experiments with specific probes for bent, straight, and unwound DNA. Biochemistry, 1996, Jun-18, Volume: 35, Issue:24 Topics: Aminoglycosides; Anti-Bacterial Agents; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Base Sequence; Binding Sites; Deoxyribonuclease I; DNA Replication; DNA, Viral; Duocarmycins; Indoles; Leucomycins; Models, Genetic; Models, Structural; Molecular Sequence Data; Oligodeoxyribonucleotides; Plasmids; Replication Origin; Restriction Mapping; Simian virus 40; Urea	1996
Myelotoxic effects of the bifunctional alkylating agent bizelesin on human, canine and murine myeloid progenitor cells. Cancer chemotherapy and pharmacology, 1996, Volume: 39, Issue:1-2 Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow; Dogs; Duocarmycins; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indoles; Male; Mice; Mice, Inbred BALB C; Species Specificity; Stem Cells; Urea	1996
Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells. Biochimica et biophysica acta, 1997, Jul-17, Volume: 1353, Issue:1 Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line; Cross-Linking Reagents; DNA Replication; DNA, Viral; Duocarmycins; Haplorhini; Indoles; Replicon; Simian virus 40; Urea	1997
Preclinical antitumor activity of bizelesin in mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:7 Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Drug Administration Schedule; Drug Resistance, Neoplasm; Duocarmycins; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Transplantation, Heterologous; Urea	1996
The novel cyclopropapyrroloindole(CPI) bisalkylators bearing methoxycarbonyl and trifluoromethyl groups. Bioorganic & medicinal chemistry letters, 1998, Jun-02, Volume: 8, Issue:11 Topics: Animals; Antineoplastic Agents, Alkylating; Drug Screening Assays, Antitumor; Duocarmycins; HeLa Cells; Humans; Indoles; Inhibitory Concentration 50; Mice; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured; Urea	1998
Induction of AT-specific DNA-interstrand crosslinks by bizelesin in genomic and simian virus 40 DNA. Biochimica et biophysica acta, 1999, Feb-16, Volume: 1444, Issue:2 Topics: Animals; Base Sequence; Cell Line; Chemical Fractionation; Chlorocebus aethiops; Cross-Linking Reagents; DNA Adducts; DNA, Viral; Duocarmycins; Electrophoresis, Agar Gel; Genetic Techniques; Indoles; Simian virus 40; Urea	1999
Comparative activity of the cyclopropylpyrroloindole compounds adozelesin, bizelesin and carzelesin in a human tumor colony-forming assay. Anti-cancer drugs, 1999, Volume: 10, Issue:3 Topics: Antineoplastic Agents; Benzofurans; Cyclohexanecarboxylic Acids; Cyclohexenes; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Tumor Cells, Cultured; Urea	1999
Bizelesin, a bifunctional cyclopropylpyrroloindole alkylating agent, inhibits simian virus 40 replication in trans by induction of an inhibitor. Biochemistry, 1999, Aug-31, Volume: 38, Issue:35 Topics: Alkylating Agents; Animals; Antiviral Agents; Cell Line; Cell-Free System; Chlorocebus aethiops; DNA Adducts; DNA Damage; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Duocarmycins; Electrophoresis, Gel, Two-Dimensional; HeLa Cells; Hot Temperature; Humans; Indoles; Simian virus 40; Trans-Activators; Urea; Virus Replication	1999
Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity. Biochemistry, 2000, Aug-15, Volume: 39, Issue:32 Topics: Alu Elements; Antineoplastic Agents, Alkylating; Apolipoproteins B; AT Rich Sequence; Benzofurans; Binding Sites; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA; DNA Adducts; DNA Damage; DNA, Mitochondrial; Duocarmycins; Genome, Human; Globins; Humans; Hypoxanthine Phosphoribosyltransferase; Indoles; Nuclear Matrix; Polymerase Chain Reaction; Proto-Oncogene Proteins c-myc; Replication Origin; Tumor Cells, Cultured; Urea	2000
Does the antitumor cyclopropylpyrroloindole antibiotic CC-1065 cross-link DNA in tumor cells? Biochemical pharmacology, 2001, Jan-01, Volume: 61, Issue:1 Topics: Antibiotics, Antineoplastic; Benzofurans; Cell Division; Cross-Linking Reagents; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA; DNA, Neoplasm; Duocarmycins; HeLa Cells; Humans; Indoles; Leucomycins; Urea	2001
Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3'-arylenebisacryloyl group as a linker. Journal of medicinal chemistry, 2001, Apr-26, Volume: 44, Issue:9 Topics: Animals; Antineoplastic Agents, Alkylating; Benzylidene Compounds; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Mice; Mice, Nude; Pyrroles; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured; Urea	2001
AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs. The Journal of biological chemistry, 2001, Nov-02, Volume: 276, Issue:44 Topics: Adenine; Antineoplastic Agents; Base Sequence; DNA; Duocarmycins; Indoles; Thymine; Urea	2001
The genome factor in region-specific DNA damage: the DNA-reactive drug U-78779 prefers mixed A/T-G/C sequences at the nucleotide level but is region-specific for long pure AT islands at the genomic level. Biochemistry, 2002, Feb-05, Volume: 41, Issue:5 Topics: Adenine Nucleotides; Antineoplastic Agents, Alkylating; Binding Sites; Cell Nucleus; Cross-Linking Reagents; Cytosine Nucleotides; Dinucleotide Repeats; DNA Adducts; DNA Damage; DNA, Neoplasm; DNA, Superhelical; DNA, Viral; Duocarmycins; Genome, Human; Guanine Nucleotides; Humans; Indoles; Intracellular Fluid; Reproducibility of Results; Sequence Analysis, DNA; Simian virus 40; Thymine Nucleotides; Tumor Cells, Cultured; Urea	2002
The DNA minor groove-alkylating cyclopropylpyrroloindole drugs adozelesin and bizelesin induce different DNA damage response pathways in human colon carcinoma HCT116 cells. Molecular cancer therapeutics, 2003, Volume: 2, Issue:7 Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzofurans; Cell Cycle; Cellular Senescence; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Duocarmycins; Humans; Indoles; Signal Transduction; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Urea	2003
Matrix attachment region (MAR) properties and abnormal expansion of AT island minisatellites in FRA16B fragile sites in leukemic CEM cells. Nucleic acids research, 2003, Nov-01, Volume: 31, Issue:21 Topics: AT Rich Sequence; Binding Sites; Cell Line, Tumor; Chromosome Fragility; Chromosomes, Human, Pair 16; DNA; DNA Sequence, Unstable; Duocarmycins; Genes, myc; Globins; Humans; Indoles; Leukemia; Minisatellite Repeats; Molecular Sequence Data; Nuclear Matrix; Nucleic Acid Conformation; Polymerase Chain Reaction; Urea	2003
Different DNA lesions trigger distinct cell death responses in HCT116 colon carcinoma cells. Molecular cancer therapeutics, 2004, Volume: 3, Issue:5 Topics: Aminoglycosides; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Benzofurans; Cell Cycle; Cell Death; Cell Proliferation; Colonic Neoplasms; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; Dose-Response Relationship, Drug; Duocarmycins; Enediynes; HCT116 Cells; Humans; Indoles; Inhibitory Concentration 50; Urea	2004
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations. Cancer research, 2004, Sep-15, Volume: 64, Issue:18 Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Mice; Mice, Nude; Pyrroles; Rats; Rats, Nude; Urea; Xenograft Model Antitumor Assays	2004
Demonstration by real-time polymerase chain reaction that cellular DNA alkylation by novel aminoindoline compounds affects expression of the protooncogene c-myc. Chemical research in toxicology, 2005, Volume: 18, Issue:2 Topics: Alkylation; Cell Line; Cell Line, Tumor; DNA; Duocarmycins; Humans; Indoles; Molecular Conformation; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors; U937 Cells; Urea	2005
Pharmacogenomic analyses of targeting the AT-rich malaria parasite genome with AT-specific alkylating drugs. Molecular and biochemical parasitology, 2007, Volume: 154, Issue:1 Topics: Alkylating Agents; Animals; Antimalarials; Base Composition; Benzofurans; Binding Sites; Centromere; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA, Protozoan; Duocarmycins; Genomic Islands; Humans; Indoles; Inhibitory Concentration 50; Molecular Structure; Parasitic Sensitivity Tests; Pharmacogenetics; Plasmodium falciparum; Sensitivity and Specificity; Urea	2007
Aberrant sporogonic development of Dmc1 (a meiotic recombinase) deficient Plasmodium berghei parasites. PloS one, 2012, Volume: 7, Issue:12 Topics: Alkylating Agents; Animals; Culicidae; DNA Damage; Duocarmycins; Female; Gene Knockout Techniques; Gene Targeting; Genes, Protozoan; Indoles; Kinetics; Life Cycle Stages; Male; Mice; Oocysts; Parasites; Plasmodium berghei; Protozoan Proteins; Recombinases; Reproduction, Asexual; Sporozoites; Urea	2012