NSC 290205: homo-aza-steroidal ester of p-bis(2-chloroethyl) amino phenyl acetic acid; RN given refers to (3beta,5alpha)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 3034220 |
| CHEMBL ID | 4173153 |
| MeSH ID | M0068996 |
| Synonym |
|---|
| nsc-620482 |
| dal-8 |
| 43000-65-3 |
| nsc-290205 |
| nsc290205 , |
| nsc 620482 |
| ccris 2146 |
| 17a-aza-d-homoandrostan-17-one, 3-(((4-(bis(2-chloroethyl)amino)phenyl)acetyl)oxy)-, (3-beta,5-alpha)- |
| homo-aza-steroidal ester of p-bis(2-chloroethyl)aminophenyl-acetic acid |
| chlorambucil ester of 3-beta-hydroxy-13a-amino-13,17-seco-5a-androstan-17-oic-13,17-lactam |
| acetic acid, (4-(bis(2-chloroethyl)amino)phenyl)-, 17-oxo-d-homo-17a-azaandrostan-3-yl ester |
| n-s 90205 |
| nsc 290205 |
| homo-azasteroidal ester of p-bis(2-chloroethyl)aminophenylacetic acid |
| [(4as,4br,6as,8s,10as,10bs,12as)-10a,12a-dimethyl-2-oxo-3,4,4a,4b,5,6,6a,7,8,9,10,10b,11,12-tetradecahydro-1h-naphtho[2,1-f]quinolin-8-yl] 2-[4-[bis(2-chloroethyl)amino]phenyl]acetate |
| unii-41dcr34631 |
| lactandrate |
| 41dcr34631 , |
| ase (azahomosteroid) |
| benzeneacetic acid, 4-(bis(2-chloroethyl)amino)-, octadecahydro-10a,12a-dimethyl-2-oxonaphtho(2,1-f)quinolin-8-yl ester, (4as-(4a.alpha.,4b.beta.,6a.alpha.,8.beta.,10a.beta.,10b.alpha.,12a.beta.))- |
| benzeneacetic acid, 4-(bis(2-chloroethyl)amino)-, (4as,4br,6as,8s,10as,10bs,12as)-octadecahydro-10a,12a-dimethyl-2-oxonaphtho(2,1-f)quinolin-8-yl ester |
| 3-(((4-(bis(2-chloroethyl)amino)phenyl)acetyl)oxy)-17a-aza-d-homoandrostan-17-one, (3.beta.,5.alpha.)- |
| DTXSID40195626 |
| homo-azasteroidal ester of p-bis(2-chloroethyl)aminophenyl acetic acid |
| (4as,4br,6as,8s,10as,10bs,12as)-10a,12a-dimethyl-2-oxooctadecahydronaphtho[2,1-f]quinolin-8-yl 2-(4-(bis(2-chloroethyl)amino)phenyl)acetate |
| Q27258433 |
| CHEMBL4173153 |
| AKOS040752378 |
| benzeneacetic acid, 4-[bis(2-chloroethyl)amino]-, (4as,4br,6as,8s,10as,10bs,12as)-octadecahydro-10a,12a-dimethyl-2-oxonaphtho[2,1-f]quinolin-8-yl ester |
NSC 290205 (A) is a hybrid synthetic antitumor ester. It combines a D-lactam derivative of androsterone and nitrogen mustard.
| Excerpt | Reference | Relevance |
|---|---|---|
| "NSC 290205 (A) is a hybrid synthetic antitumor ester, which combines a D-lactam derivative of androsterone and nitrogen mustard. " | ( NSC 290205-based therapy in murine pancreatic adenocarcinoma PAN02 in combination with adriamycin (ADR). Andreadis, C; Boutis, A; Lialiaris, TS; Mouratidou, D; Papageorgiou, A, ) | 3.02 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " In this study, the antitumor activity of A in combination with ADR (AHOP) was investigated in comparison with the standard CHOP regimen." | ( NSC 290205-based therapy in murine pancreatic adenocarcinoma PAN02 in combination with adriamycin (ADR). Andreadis, C; Boutis, A; Lialiaris, TS; Mouratidou, D; Papageorgiou, A, ) | 1.57 |
| "It is very likely that the D-lactamic steroid (androstan) alkylator forA, containing the amide group -NH-CO-, combined with ADR which intercalates between DNA base-pairs, is the explanation for the higher activity of AHOP as compared to CHOP." | ( NSC 290205-based therapy in murine pancreatic adenocarcinoma PAN02 in combination with adriamycin (ADR). Andreadis, C; Boutis, A; Lialiaris, TS; Mouratidou, D; Papageorgiou, A, ) | 1.57 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1357933 | Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives. |
| AID1357935 | Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives. |
| AID1357934 | Growth inhibition of human MCF7 cells after 48 by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives. |
| AID1357951 | Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives. |
| AID1357952 | Growth inhibition of human T47D cells after 48 by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (5.56%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 17 (94.44%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||