nsc-290205 has been researched along with Leukemia-P388* in 2 studies
2 other study(ies) available for nsc-290205 and Leukemia-P388
| Article | Year |
|---|---|
Further study on the antitumor activity of a homo-aza-steroidal ester of p-N,N-bis(2-chloroethyl)aminophenylacetic acid.
Topics: Animals; Antineoplastic Agents; Azasteroids; Female; Leukemia P388; Male; Mice; Nitrogen Mustard Compounds; Receptors, Steroid | 1990 |
A new steroidal alkylating agent with improved activity in advanced murine leukemias.
The homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenoxy] acetic acid, 3 beta-hydroxy 13 alpha - amino - 13,17 - seco - 5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenoxyacetate, gave a 100% increase in lifespan over controls in the treatment of L1210 leukemia by IP administration on a days 1 and 4 treatment schedule. This ester gave a maximum activity of 383% increased lifespan over controls in the treatment of P388 leukemia by IP administration on a daily treatment schedule. Activity in advanced L1210 (41% increased lifespan) and P388 leukemias (173% increased lifespan) was maintained, indicating that this compound is the most promising of a number of congeners tested to date. Topics: Alkylating Agents; Animals; Azasteroids; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred Strains; Nitrogen Mustard Compounds; Steroids, Heterocyclic; Time Factors | 1979 |