nsc-290205 has been researched along with Carcinoma* in 1 studies
1 other study(ies) available for nsc-290205 and Carcinoma
| Article | Year |
|---|---|
Activity of 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstane-17-oic-13,17-lactam(p-(bis(2-chloroethyl)amino)-phenyl) acetate(NSC 290205) in murine solid tumors.
The modified steroidal alkylating agent, 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstane-17-oic-13,17-lactam[p-[bis(2-chloroethyl)amino]-phenyl]acetate showed excellent activity in treatment of there murine solid tumors. Colon 26-bearing CD2F1 mice lived twice as long as controls with tumor free survivors at the end of the 70-day observation period. CD8F1 mammary tumor growth was suppressed greater than 90% compared to controls. B16 melanoma-bearing B6D2F1 mice lived 50% longer than controls. This agent had previously been shown to be active in treatment of the Theagenion-Bahner angiosarcoma, the T8 Guerin tumor, L1210 leukemia and P388 leukemia. Topics: Animals; Azasteroids; Carcinoma; Colonic Neoplasms; Female; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Melanoma; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds | 1982 |