nsc-290205 has been researched along with Colonic-Neoplasms* in 2 studies
2 other study(ies) available for nsc-290205 and Colonic-Neoplasms
| Article | Year |
|---|---|
Further studies on the anti-neoplastic activity of 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam [p-[bis(2-chloroethyl)amino]-phenyl]acetate (NSC 290205).
The modified steroidal alkylating agent 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam [p-[bis(2-chloroethyl)amino]phenyl]acetate (NSC 290205) is active in treating the LX-1 lung and MX-1 breast xenografts as well as a number of rodent tumors. Of 13 tumors tested, activity has been shown in 10 systems. Two systems have not received adequate testing and negative results were recorded in 1 system. Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azasteroids; Breast Neoplasms; Cell Line; Colonic Neoplasms; Drug Evaluation, Preclinical; Humans; Leukemia, Experimental; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Mice; Neoplasm Transplantation; Neoplasms; Nitrogen Mustard Compounds | 1984 |
Activity of 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstane-17-oic-13,17-lactam(p-(bis(2-chloroethyl)amino)-phenyl) acetate(NSC 290205) in murine solid tumors.
The modified steroidal alkylating agent, 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstane-17-oic-13,17-lactam[p-[bis(2-chloroethyl)amino]-phenyl]acetate showed excellent activity in treatment of there murine solid tumors. Colon 26-bearing CD2F1 mice lived twice as long as controls with tumor free survivors at the end of the 70-day observation period. CD8F1 mammary tumor growth was suppressed greater than 90% compared to controls. B16 melanoma-bearing B6D2F1 mice lived 50% longer than controls. This agent had previously been shown to be active in treatment of the Theagenion-Bahner angiosarcoma, the T8 Guerin tumor, L1210 leukemia and P388 leukemia. Topics: Animals; Azasteroids; Carcinoma; Colonic Neoplasms; Female; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Melanoma; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds | 1982 |