nsc-290205 and Carcinoma--Ehrlich-Tumor

nsc-290205 has been researched along with Carcinoma--Ehrlich-Tumor* in 2 studies

Other Studies

2 other study(ies) available for nsc-290205 and Carcinoma--Ehrlich-Tumor

Article	Year
Studies on the effect of homo-aza-steroidal ester of p-bis (2-chloroethyl) amino phenyl acetic acid in Ehrlich ascites tumor cells. Methods and findings in experimental and clinical pharmacology, 1984, Volume: 6, Issue:1 The effect of a homo-aza-steroidal ester (ASE) on the incorporation of radioactive precursor to DNA of Ehrlich ascites tumor (EAT) cells has been investigated. We found that treatment of cells with 80 micrograms/ml of ASE for 2 hours causes an inhibition of the incorporation of 3H-thymidine to DNA by 71%. This is partly because ASE affects the radioactive thymidine pool in the cell. The DNA from EAT cells after centrifugation in CsCl is shifted to higher densities when ASE is present throughout the experiment. This density shift was not observed when ASE was incubated only in the growth medium of the cells. Topics: Animals; Antineoplastic Agents; Azasteroids; Carcinoma, Ehrlich Tumor; Cells, Cultured; Centrifugation, Density Gradient; Cesium; Chlorides; DNA, Neoplasm; Mice; Nitrogen Mustard Compounds; Thymidine; Time Factors	1984
Interaction of homo-aza-steroidal ester of [p-[bis-(2-chloroethyl) amino]phenyl]acetic acid (ASE) with DNA of Ehrlich ascites tumor cells. FEBS letters, 1983, Mar-07, Volume: 153, Issue:1 A cytostatic, homo-aza-steroidal ester of [p-[bis-(2-chloroethyl) amino]phenyl]acetic acid (ASE) was reduced with NaB3H4 and [3H]ASE-treated DNA prepared in vitro. We found that: (1) ASE reacts preferentially with purines; (2) ASE decreases the thermal stability of the double helix upon binding to DNA; (3) [3H]ASE binding sites are clustered along the DNA molecules; (4) ASE binding sites probably represent oligo- or polypurine sequences. Topics: Animals; Antineoplastic Agents; Azasteroids; Borohydrides; Carcinoma, Ehrlich Tumor; DNA; Drug Stability; Hot Temperature; Kinetics; Mice; Nitrogen Mustard Compounds; Nucleic Acid Conformation; Oxidation-Reduction; Purines	1983

Article

Year

Studies on the effect of homo-aza-steroidal ester of p-bis (2-chloroethyl) amino phenyl acetic acid in Ehrlich ascites tumor cells.

Methods and findings in experimental and clinical pharmacology, 1984, Volume: 6, Issue:1

The effect of a homo-aza-steroidal ester (ASE) on the incorporation of radioactive precursor to DNA of Ehrlich ascites tumor (EAT) cells has been investigated. We found that treatment of cells with 80 micrograms/ml of ASE for 2 hours causes an inhibition of the incorporation of 3H-thymidine to DNA by 71%. This is partly because ASE affects the radioactive thymidine pool in the cell. The DNA from EAT cells after centrifugation in CsCl is shifted to higher densities when ASE is present throughout the experiment. This density shift was not observed when ASE was incubated only in the growth medium of the cells.

Topics: Animals; Antineoplastic Agents; Azasteroids; Carcinoma, Ehrlich Tumor; Cells, Cultured; Centrifugation, Density Gradient; Cesium; Chlorides; DNA, Neoplasm; Mice; Nitrogen Mustard Compounds; Thymidine; Time Factors

1984

Interaction of homo-aza-steroidal ester of [p-[bis-(2-chloroethyl) amino]phenyl]acetic acid (ASE) with DNA of Ehrlich ascites tumor cells.

FEBS letters, 1983, Mar-07, Volume: 153, Issue:1

A cytostatic, homo-aza-steroidal ester of [p-[bis-(2-chloroethyl) amino]phenyl]acetic acid (ASE) was reduced with NaB3H4 and [3H]ASE-treated DNA prepared in vitro. We found that: (1) ASE reacts preferentially with purines; (2) ASE decreases the thermal stability of the double helix upon binding to DNA; (3) [3H]ASE binding sites are clustered along the DNA molecules; (4) ASE binding sites probably represent oligo- or polypurine sequences.

Topics: Animals; Antineoplastic Agents; Azasteroids; Borohydrides; Carcinoma, Ehrlich Tumor; DNA; Drug Stability; Hot Temperature; Kinetics; Mice; Nitrogen Mustard Compounds; Nucleic Acid Conformation; Oxidation-Reduction; Purines

1983