n-isobutyrylglycine profile

N-isobutyrylglycine: found in urine of patients with glyceric acidemia [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N-isobutyrylglycine : An N-acylglycine in which the acyl group is specified as isobutryl. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	10855600
CHEMBL ID	2158191
CHEBI ID	70979
SCHEMBL ID	622544
MeSH ID	M0087778

Synonym
2-(2-methylpropanamido)acetic acid
EN300-31100
BB 0217128
(isobutyrylamino)aceticacid
n-isobutyrylglycine
n-(2-methylpropanoyl)glycine
AKOS000100039
2-(2-methylpropanoylamino)acetic acid
(isobutyrylamino)acetic acid
15926-18-8
2-(isobutyrylamino)acetic acid
CHEMBL2158191
FT-0670430
[(2-methylpropanoyl)amino]acetic acid
n-isobutanoylglycine
isobutanoylglycine
CHEBI:70979 ,
isobutyrylglycine
SCHEMBL622544
AB01332908-02
2-isobutyramidoacetic acid
DTXSID10445943
(isobutyrylamino)acetic acid, aldrichcpr
mfcd09043666
n-isobutyrylglycine (isobutyryl-gly-oh)
n-isobutyrylglycine, analytical reference material
AS-61842
isobutyrylamino acetic acid
F20066
J-009586
NCGC00340663-01
Q27139227
glycine, n-(2-methyl-1-oxopropyl)-
CS-0201719
iso-butyrylglycine
unii-4cwa98g3l7
4cwa98g3l7 ,
n-(2-methyl-1-oxopropyl)glycine
A856021
1219795-05-7
2-isobutyramidoaceticacid
HY-W141928
isobutyroyl glycine-2d2
Z85886685

Role	Description
human urinary metabolite	Any metabolite (endogenous or exogenous) found in human urine samples.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
N-acylglycine	An N-acyl-amino acid in which amino acid specified is glycine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Leucine, isoleucine and valine metabolism	24	70

Assay ID	Title	Year	Journal	Article
AID695876	Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
AID695877	Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay	2011	Journal of medicinal chemistry, Jul-28, Volume: 54, Issue:14	Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (40.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (40.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	3 (60.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carnitine [no description available]	1.99	1	amino-acid betaine	human metabolite; mouse metabolite
glycine [no description available]	3.09	5	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
glyceric acid glyceric acid: found in urine of patient with D-glyceric acidemia & hyperglycinaemia; RN given refers to parent cpd without isomeric designation. glycerol ether : Any ether having glyceryl as at least one of the O-substituents.. glyceric acid : A trionic acid that consists of propionic acid substituted at positions 2 and 3 by hydroxy groups.	1.96	1	trionic acid	fundamental metabolite
cystamine [no description available]	2.06	1	organic disulfide; primary amino compound	EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor
thiorphan Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.	2.06	1	N-acyl-amino acid
ethylmaleimide Ethylmaleimide: A sulfhydryl reagent that is widely used in experimental biochemical studies.	2.06	1	maleimides	anticoronaviral agent; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.1.1 (hexokinase) inhibitor
tiopronin Tiopronin: Sulfhydryl acylated derivative of GLYCINE.	2.06	1	N-acyl-amino acid
penicillamine Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.. penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.	2.06	1	non-proteinogenic alpha-amino acid; penicillamine	antirheumatic drug; chelator; copper chelator; drug allergen
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	1.96	1	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.06	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
captopril Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.. captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.	2.06	1	alkanethiol; L-proline derivative; N-acylpyrrolidine; pyrrolidinemonocarboxylic acid	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
stepronin [no description available]	2.06	1	N-acyl-amino acid
thiolactic acid thiolactic acid: RN given refers to parent cpd	2.06	1	mercaptopropanoic acid
cystine L-cystine : The L-enantiomer of the sulfur-containing amino acid cystine.	2.06	1	cystine zwitterion; cystine; L-cysteine derivative; non-proteinogenic L-alpha-amino acid	EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitor; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
n-butyrylglycine butyrylglycine : A N-acylglycine obtained by formal condensation of the carboxy group of butyric acid with the amino group of glycine.	2.38	2	N-acylglycine	human urinary metabolite
n-caproylglycine N-hexanoylglycine : An N-acylglycine in which the acyl group is specified as hexanoyl.	1.99	1	N-acylglycine	metabolite
racecadotril racecadotril: parenterally active enkephalinase inhibitor	2.06	1	N-acyl-amino acid
caprylates Caprylates: Derivatives of caprylic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure.. octanoate : A straight-chain saturated fatty acid anion that is the conjugate base of octanoic acid (caprylic acid); believed to block adipogenesis.	1.95	1	fatty acid anion 8:0; straight-chain saturated fatty acid anion	human metabolite; Saccharomyces cerevisiae metabolite
buthionine sulfoximine L-buthionine-(S,R)-sulfoximine : A 2-amino-4-(S-butylsulfonimidoyl)butanoic acid which has S-configuration. It is a inhibitor of gamma-glutamylcysteine synthetase and glutathione (GSH) biosynthesis and is capable of enhancing the apoptotic effects of several chemotherapeutic agents.	2.06	1	2-amino-4-(S-butylsulfonimidoyl)butanoic acid	EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor; ferroptosis inducer
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	1.96	1	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
tariquidar [no description available]	2.06	1	benzamides
2-methylbutyrylglycine 2-methylbutyrylglycine: metabolite of L-isoleucine. N-(2-methylbutanoyl)glycine : A N-acylglycine that is glycine substituted by a 2-methylbutanoyl group at the N atom.	2.66	3	N-acylglycine	human metabolite
dithiothreitol [no description available]	2.06	1	1,4-dithiothreitol
cysteinylglycine cysteinylglycine: RN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83. L-cysteinylglycine : A dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism.	2.06	1	dipeptide zwitterion; dipeptide	Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite
riboflavin vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).	1.96	1	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite
n-isovalerylglycine N-isovalerylglycine: urinary metabolite of isovaleric acid in isovaleric acidemia (sweaty feet syndrome). N-isovalerylglycine : An N-acylglycine in which the acyl group is specified as isovaleryl.	2.66	3	N-acylglycine	human urinary metabolite
D-fructopyranose [no description available]	1.96	1	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent
tiglylglycine tiglylglycine: RN is from 9th CI. tiglylglycine : An N-acylglycine that is glycine with an amine hydrogen substituted by a 2-methylbut-2-enoyl (tiglyl) group.	1.95	1	N-acylglycine	metabolite

Condition	Relationship Strength	Studies
Amino Acid Metabolism Disorders, Inborn [description not available]	2.67	3
Acquired Metabolic Diseases, Brain [description not available]	2.05	1
Deficiency, Riboflavin [description not available]	1.99	1

n-isobutyrylglycine

Description

Cross-References

Synonyms (44)

Roles (1)

Drug Classes (1)

Pathways (1)

Bioassays (2)

Research

Studies (5)

Study Types