maysin and Diabetes-Mellitus--Type-2

Maize silks have been used in Mexico for centuries as a natural-based treatment for various illnesses, including obesity and diabetes. It has been shown in mice that intake of maize silk extracts reduces the levels of blood glucose. However, it is not clear how or what maize silk compounds are involved in such an effect. A hypothesized mechanism is that some maize silk compounds can inhibit carbohydrate hydrolyzing enzymes like α-glucosidases. This work aimed to assess the capability of both saccharides and phenolic compounds from maize silks to inhibit intestinal α-glucosidases. Results showed that saccharides from maize silks did not produce inhibition on intestinal α-glucosidases, but phenolics did. Maize silk phenolics increased the value of K

Topics: alpha-Glucosidases; Blood Glucose; Diabetes Mellitus, Type 2; Flavonoids; Flowers; Glucosides; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Intestines; Kinetics; Molecular Docking Simulation; Phenols; Plant Extracts; Polyphenols; Zea mays