isobutyl chloroformate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	62365
SCHEMBL ID	1745
MeSH ID	M0117769

Synonyms (70)

Synonym
chlorocarbonic acid isobutyl ester
2-methylpropyl carbonochloridate
2-methylpropyl chloroformate
isobutyl chloroformate
chloroformic acid isobutyl ester
nsc8429
543-27-1
carbonochloridic acid, 2-methylpropyl ester
isobutyl chlorocarbonate
nsc-8429
inchi=1/c5h9clo2/c1-4(2)3-8-5(6)7/h4h,3h2,1-2h
isobutyl chloroformate, 98%
i-butyl chloroformate
AKOS000121338
A7899
isobutyl carbonochloridate
iso-butylchloroformate
isobutylchloroformate
BBL011424
unii-6s785tc0ob
einecs 208-840-1
formic acid, chloro-, isobutyl ester
6s785tc0ob ,
isobutyl chloroformate [na2742] [poison]
nsc 8429
STL146531
FT-0627353
BP-31022
SCHEMBL1745
carbonochloridic acid 2-methylpropyl ester
isobutyl chlorocarbonate [mi]
i-buococl
isobutyichioroformate
chloroformic acid isobutyl-ester
2-methylpropyl chlorocarbonate
isobutylchoroformate
clcooi-bu
isobutyl choroformate
iso-butyl chloroformate
2-methylpropyloxycarbonylchloride
isobutyl chloroform ate
chloroformic acid iso-butyl ester
ibuococl
clco2ibu
i-butylchloroformate
clco2i-bu
chloroformic acid isobutylester
ibcf
isobutyl chloridocarbonate
iso-butyl-chloroformate
isobutyl chloroformat
isobutylchlorocarbonate
2-methylpropylchloroformate
chloroformic acid-isobutylester
isobutyl-chloroformate
isobutyl chloro-formate
isobutyloxycarbonyl chloride
isobutyl chioroformate
isobutlychloroformate
2-methylpropoxycarbonyl chloride
isobutyl chlo-roformate
isobutylchlorformate
DTXSID8052194
F0001-1428
mfcd00000642
isobutyl chloroformate, purum, >=98.0% (gc)
VS-02945
Q27265420
SB40458
EN300-17639

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" From the calculation of the excretion kinetics it was found that the dosage absorbed was eliminated within 15 h after exposure."	( Analytical method for biomonitoring of perfluoroalkyl acids in human urine. Ballesteros, E; Gallego, M; Jurado-Sánchez, B, 2014)	0.4

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (12.50)	18.7374
1990's	4 (25.00)	18.2507
2000's	5 (31.25)	29.6817
2010's	4 (25.00)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 45.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	45.25 (24.57)
Research Supply Index	2.89 (2.92)
Research Growth Index	4.77 (4.65)
Search Engine Demand Index	64.56 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (45.25)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamates [no description available]	2.04	1	amino-acid anion
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.06	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
cycloleucine Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.. 1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.	1.99	1	non-proteinogenic alpha-amino acid	EC 2.5.1.6 (methionine adenosyltransferase) inhibitor
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	1.96	1	pentacarboxylic acid	copper chelator
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
dimethylformamide Dimethylformamide: A formamide in which the amino hydrogens are replaced by methyl groups.. N,N-dimethylformamide : A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.	1.96	1	formamides; volatile organic compound	geroprotector; hepatotoxic agent; polar aprotic solvent
diazomethane Diazomethane: A diazonium compound with the formula CH2N2.. diazomethane : The simplest diazo compound, in which a diazo group is attached to a methylene group.	1.99	1	diazo compound	alkylating agent; antineoplastic agent; carcinogenic agent; poison
dicyclohexylcarbodiimide 1,3-dicyclohexylcarbodiimide : A carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms.	1.98	1	carbodiimide	ATP synthase inhibitor; cross-linking reagent; peptide coupling reagent
1,6-diaminohexane 1,6-diaminohexane: Russian drug; RN given refers to parent cpd; structure. hexane-1,6-diamine : A C6 alkane-alpha,omega-diamine.	2.04	1	alkane-alpha,omega-diamine	human xenobiotic metabolite
perfluorooctane sulfonic acid perfluorooctane-1-sulfonic acid : A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.	2.1	1	perfluoroalkanesulfonic acid	antilipemic drug; persistent organic pollutant
homocysteine Homocysteine: A thiol-containing amino acid formed by a demethylation of METHIONINE.. homocysteine : A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.. L-homocysteine : A homocysteine that has L configuration.	2.17	1	amino acid zwitterion; homocysteine; serine family amino acid	fundamental metabolite; mouse metabolite
triiodothyronine L-homocysteine thiolactone : A thiolactone arising from formal condensation of the mercapto (sulfanyl) and carboxylic acid groups of L-homocysteine.	2.17	1	tetrahydrothiophenes; thiolactone	human metabolite
carbodiimides Carbodiimides: Compounds with the general formula RN=C=NR, where R is a hydrocarbyl group.. methanediimine : A carbodiimide in which both nitrogens are unsubstituted.	2	1	carbodiimide
dithioerythritol [no description available]	1.99	1	1,4-dimercaptobutane-2,3-diol	reducing agent
indium Indium: A metallic element, atomic number 49, atomic weight 114.818, symbol In. It is named from its blue line in the spectrum.. indium atom : A metallic element first identified and named from the brilliant indigo (Latin indicum) blue line in its flame spectrum.	1.96	1	boron group element atom
fumarates Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)	2.06	1	butenedioate; C4-dicarboxylate	human metabolite; metabolite; Saccharomyces cerevisiae metabolite
calpain Calpain: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.	2	1

Condition	Relationship Strength	Studies
BCKD Deficiency [description not available]	2.02	1
BH4 Deficiency [description not available]	2.02	1
Maple Syrup Urine Disease An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain amino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a maple syrup odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936)	2.02	1
Phenylketonurias A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).	2.02	1
Breast Cancer [description not available]	2.04	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.04	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.04	1

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