disperse orange 3

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Disperse Orange 3, also known as C.I. Solvent Orange 7, is an azo dye widely used in the textile industry for dyeing synthetic fibers like polyester and nylon. It is typically synthesized through a diazotization and coupling reaction involving an aromatic amine and a diazonium salt. Disperse Orange 3 is known for its vibrant orange color and good lightfastness. It is often used in the production of clothing, carpets, and other textile materials. The compound is studied due to its potential environmental impacts, as its release into waterways can contribute to water pollution and harm aquatic life. Research focuses on developing sustainable alternatives and optimizing dyeing processes to minimize environmental impact.'

4-(4-nitrophenylazo)aniline : Azobenzene substituted at the phenyl 4-positions by an amino and a nitro group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	12896
CHEBI ID	75648
SCHEMBL ID	15922
MeSH ID	M0122438

Synonyms (47)

Synonym
730-40-5
b7j3o076ot ,
c.i. disperse orange 3
unii-b7j3o076ot
benzenamine, 4-(2-(4-nitrophenyl)diazenyl)-
4-(4-nitrophenylazo)aniline
benzenamine, 4-[(4-nitrophenyl)azo]-
4-amino-4'-nitroazobenzene
disperse orange 3, dye content 90 %
do3 ,
4-((4-nitrophenyl)azo)aniline
ci 11005
disperse orange 3
benzenamine, 4-((4-nitrophenyl)azo)-
4-((4-nitrophenyl)azo)benzenamine
benzeneamine, 4-((nitrophenyl)azo)-
einecs 211-984-8
4-[(4-nitrophenyl)diazenyl]aniline
4-(2-(4-nitrophenyl)diazenyl)benzenamine
4-[(4-nitrophenyl)azo]benzenamine
4-(4-nitroazophenyl)aniline
CHEBI:75648
1-(4'-aminophenylazo)-4-nitrobenzene
4-((nitrophenyl)azo)benzeneamine
4-(4'-nitroazophenyl)anilin
4-[(4-nitrophenyl)azo]benzenamin
4-((4-nitrophenyl)diazenyl)aniline
AKOS015902549
70734-98-4
SCHEMBL15922
DTXSID7061061
UNBOSJFEZZJZLR-UHFFFAOYSA-N
T487 ,
UNBOSJFEZZJZLR-CCEZHUSRSA-N
benzenamine, 4-[2-(4-nitrophenyl)diazenyl]-
disperse orange 3 [inci]
4-(4'-nitrophenylazo)aniline
lowadene orange 3
AKOS028108375
disperse orange 3, analytical standard
mfcd00007856
(e)-4-((4-nitrophenyl)diazenyl)aniline
Q26840859
E79393
trans-4-((4-nitrophenyl)azo)aniline
Q27274464
AS-81858

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

Role	Description
dye	null
allergen	A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
azobenzenes	Any member of the wide class of molecules that share the core azobenzene structure, comprising two phenyl rings linked by a N=N double bond, which may have different functional groups extending from the rings.
primary arylamine	A primary amine formally derived from ammonia by replacing one hydrogen atom by an aryl group. R-NH2 where R is an aryl group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (16)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (6.25)	18.7374
1990's	2 (12.50)	18.2507
2000's	2 (12.50)	29.6817
2010's	9 (56.25)	24.3611
2020's	2 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.14

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	35.14 (24.57)
Research Supply Index	2.94 (2.92)
Research Growth Index	5.10 (4.65)
Search Engine Demand Index	43.27 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (35.14)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (5.88%)	5.53%
Reviews	1 (5.88%)	6.00%
Case Studies	2 (11.76%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (76.47%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
2-nitropropane 2-nitropropane: RN given refers to cpd with locant for nitro moiety in 2 position. 2-nitropropane : A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC).	2.1	1	0	secondary nitroalkane	carcinogenic agent; hepatotoxic agent; polar aprotic solvent; xenobiotic
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	2.07	1	0	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
benzocaine Benzocaine: A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.. dextran sulfate sodium : An organic sodium salt of dextran sulfate. It induces colitis in mice.. benzocaine : A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.	2.1	1	0	benzoate ester; substituted aniline	allergen; antipruritic drug; sensitiser; topical anaesthetic
diphenylpyraline diphenylpyraline: RN given refers to parent cpd; structure. allergen : A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.. diphenylpyraline : A member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.	2.1	1	0	piperidines; tertiary amine	cholinergic antagonist; H1-receptor antagonist
p-aminoazobenzene p-Aminoazobenzene: Used in the form of its salts as a dye and as an intermediate in manufacture of Acid Yellow, diazo dyes, and indulines.. 4-(phenylazo)aniline : Azobenzene substituted at one of the 4-positions by an amino group. It has a role as a dye and an allergen.	2.17	1	0
propane Propane: A three carbon alkane with the formula H3CCH2CH3.	2.1	1	0	alkane; gas molecular entity	food propellant
isoprene isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.	2.15	1	0	alkadiene; hemiterpene; volatile organic compound	plant metabolite
2,5-diaminotoluene 2,5-diaminotoluene: RN given refers to parent cpd. 2-methyl-1,4-phenylenediamine : A diamine in which the two amino groups are substituted into toluene at the 2- and 5-positions.	3.44	1	1	diamine	allergen
4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane: RN given refers to parent cpd; structure. 4,4'-diaminodiphenylmethane : An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.	1.97	1	0	aromatic amine	allergen; carcinogenic agent
4-phenylenediamine 4-phenylenediamine: agent hair dye responsible for contact dermatitis; RN given refers to parent cpd. 1,4-phenylenediamine : A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.	4.68	6	1	phenylenediamine	allergen; dye; hapten; reagent
disperse blue 1 [no description available]	2.07	1	0	anthraquinone
disperse orange 1 [no description available]	2.69	2	0
dispersion yellow 3 Dispersion Yellow 3: used in carpet industry; river pollutant. 4-(2-hydroxy-5-methylphenylazo)acetanilide : An azo dye with a structure consisting of acetanilide substituted on the 4-position of the phenyl group with a 6-hydroxy-m-tolylazo group.	2.92	4	0
disperse red 1 Disperse Red 1 : An azo dye with a structure consisting of nitrobenzene substituted on the 4-position of the phenyl group with a 4-[N-ethyl-N-(2-hydroxyethyl)]phenylazo group.	2.69	3	0
n-isopropyl-n-phenyl-4-phenylenediamine N-isopropyl-N-phenyl-4-phenylenediamine: RN given refers to parent cpd; structure in sixth source	2.1	1	0
disperse blue 35 disperse blue 35: not a single chemical cpd	2.57	2	0
disperse blue 124 Disperse Blue 124: RN given refers to cpd with unknown MF. Disperse Blue 124 : A monoazo compound consisting of diazene with a 5-nitrothiazol-2-yl group attached to one nitrogen and a substituted 4-aminophenyl group attached to the other; used as a dye standard for the assay of allergy-releasing dyes in textiles.	4.38	6	0	1,3-thiazoles; monoazo compound; tertiary amine	allergen; dye; hapten
disperse blue 106 disperse blue 106: monoazo textile dye used on polyester blouses; no other info available 12/85	4.11	4	0
metanil yellow metanil yellow: RN given refers to parent cpd; structure. metanil yellow : An organic sodium salt having 3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonate as the counterion. Used in one variant of Masson's trichrome to stain collagen yellow in contrast to the red muscle, but is not in common used.	2.17	1	0	organic sodium salt	histological dye
basic red 46 basic red 46: monoazoic dye used for acrylic textiles implicated in contact dermatitis	2.17	1	0
piperidines Piperidines: A family of hexahydropyridines.	2.1	1	0

Condition	Relationship Strength	Studies	Trials
Allergic Contact Dermatitis [description not available]	6.17	11	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	6.17	11	1
Dermatitis, Occupational A recurrent contact dermatitis caused by substances found in the work place.	2.61	2	0
Hand Dermatosis [description not available]	2.17	1	0
Hand Dermatoses Skin diseases involving the HANDS.	2.17	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	3.86	2	1
Contact Dermatitis [description not available]	2.37	2	0
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	2.37	2	0

chemdatabank.com