Target type: cellularcomponent
A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. [GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor]
The AP-1 complex, a crucial transcription factor in eukaryotic cells, is a heterodimer consisting of proteins from the Jun and Fos families. These proteins, which are leucine zipper transcription factors, interact via their leucine zipper motifs, forming a dimer that binds to DNA at specific recognition sequences known as AP-1 sites. The cellular component of the AP-1 complex encompasses various nuclear structures and compartments. It is predominantly localized in the nucleus, specifically within the chromatin, where it interacts with DNA to regulate gene expression. The AP-1 complex can also be found associated with other nuclear structures such as the nucleolus and nuclear bodies. The complex's dynamic nature enables it to shuttle between the cytoplasm and nucleus, responding to various cellular signals. Once in the nucleus, it interacts with other transcription factors, co-activators, and co-repressors to modulate gene expression. These interactions are crucial for the complex's ability to fine-tune transcriptional responses to various stimuli. The precise cellular component of the AP-1 complex may vary depending on the specific cell type, the cellular context, and the specific Jun and Fos proteins involved in the complex formation. However, its primary localization within the nucleus, particularly at the chromatin, highlights its role as a master regulator of gene expression.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Transcription factor AP-1 | A transcription factor Jun that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05412] | Homo sapiens (human) |
| Proto-oncogene c-Fos | A protein c-Fos that is encoded in the genome of human. [PRO:DNx, UniProtKB:P01100] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| masoprocol | nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata) | catechols; lignan; tetrol | antioxidant; ferroptosis inhibitor; geroprotector; plant metabolite |
| tylophorinidine | tylophorinidine: antileukemic agent from T. indica | ||
| dihydroguaiaretic acid | dihydroguaiaretic acid: lignan extracted form Larrea divaricata; inhibitory to beef heart mitochondrial succinoxidase & NADH-oxidase; RN given refers to cpd without isomeric designation | ||
| dcb 3503 | |||
| glaucarubinone | carboxylic ester; organic heteropentacyclic compound; quassinoid; secondary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone; tetrol | antimalarial; antineoplastic agent; geroprotector; plant metabolite | |
| rosmarinic acid | (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid. rosmarinic acid: RN given refers to parent cpd; promote OT project | rosmarinic acid | geroprotector; plant metabolite |
| sl 327 | SL 327: a MEK inhibitor SL-327 : A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4-aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2. | ||
| spc-839 | SPC-839: an inhibitor of activator protein 1; structure in first source | ||
| sp 100030 | N-(3,5-bis(trifluoromethyl)phenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide: transcription factor inhibitor specific to T-cells |