Page last updated: 2024-12-05

butyl isocyanate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

n-butyl isocyanate : An isocyanate having a butyl group attached to the nitrogen. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID8110
CHEMBL ID27104
CHEBI ID136519
MeSH IDM0043138

Synonyms (50)

Synonym
STL308735
BIC ,
1-isocyanatobutane
111-36-4
einecs 203-862-8
n-butyl isocyanate
hsdb 5548
un2485
butyl isocyanate ,
isocyanic acid, butyl ester
butane, 1-isocyanato-
butyl isocyanate, 98%
1-butyl isocyanate
CHEBI:136519 ,
CHEMBL27104
1-isocyanato-butane
AKOS000120793
NCGC00248614-01
tox21_200437
NCGC00257991-01
dtxcid106872
dtxsid6026872 ,
cas-111-36-4
I0118
isocyanic acid butyl ester
n-butyl isocyanate [un2485] [poison]
unii-xm89t89j3w
xm89t89j3w ,
ec 203-862-8
FT-0627393
EPITOPE ID:122969
1-butylisocyanate
n-butylisocyanate
n-butyl-isocyanate
butyl isocynate
butylisocyanate
n-butyliso-cyanate
BBL027371
isocyanic acid n-butyl ester
un 2485
n-c4h9nco
butyl isocyanate [mi]
butyl isocyanate, n-
n-butyl isocyanate [hsdb]
mfcd00002046
J-519964
GS-3292
Q15632798
25067-04-3
EN300-20857

Research Excerpts

Overview

N-Butyl isocyanate is known to be a contact irritant. If the benomyl-coated seeds were not properly dried before storage in the warehouse n-butyl isOCyanate would have been produced.

ExcerptReferenceRelevance
"n-Butyl isocyanate is known to be a contact irritant and if the benomyl-coated seeds were not properly dried before storage in the warehouse n-butyl isocyanate would have been produced."( Ocular irritation from product of pesticide degradation among workers in a seed warehouse.
Itoh, H; Matsukawa, T; Yokoyama, K, 2015
)
0.98

Actions

ExcerptReferenceRelevance
"Butyl isocyanate did not cause any noticeable effect on cell ultrastructure and the apparently low rate of penetration of carbendazim into cells made it impossible to obtain an effect which justified ultrastructural analysis."( The effects of benomyl and its breakdown products carbendazim and butyl isocyanate on the structure and function of tracheal ciliated cells.
Kennedy, JR; Kucera, SP; Schultz, TW; Swann, JM, 1995
)
1.25

Toxicity

ExcerptReferenceRelevance
"We investigated the toxic effects of carbendazim and n-butyl isocyanate (BIC), metabolites of the fungicide benomyl, on development in the African clawed frog, Xenopus laevis."( Toxic effects of carbendazim and n-butyl isocyanate, metabolites of the fungicide benomyl, on early development in the African clawed frog, Xenopus laevis.
Cheong, SW; Hong, SJ; Hwang, YG; Jin, JH; Kim, SJ; Park, JH; Yeo, CY; Yoon, CS, 2008
)
0.87
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
allergenA chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
isocyanatesOrganonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID34174Inhibition of yeast aldehyde dehydrogenase is evaluated by formation by NADH in vitro at 10 uM concentration of compound1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase.
AID34036In vitro inhibition of yeast Alcohol dehydrogenase at 100 uM concentration of compound1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase.
AID34032In vitro inhibition of yeast Alcohol dehydrogenase is evaluated by the formation of NADH at 100 uM concentration of compound1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase.
AID34034Inhibition of yeast Alcohol dehydrogenase is evaluated by formation by NADH in vitro at 10 uM concentration of compound1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase.
AID34175In vitro inhibition of yeast aldehyde dehydrogenase at 100 uM concentration of compound1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase.
AID34035In vitro inhibition of yeast Alcohol dehydrogenase at 1 uM concentration of compound1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (22.22)18.7374
1990's6 (33.33)18.2507
2000's4 (22.22)29.6817
2010's4 (22.22)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index37.25 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index47.49 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (37.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]