aconine: alkaloid isolated from Aconitum carmichaeli; structure in Merck [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
aconine : A diterpene alkaloid with formula C25H41NO9 that is isolated from several Aconitum species. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Aconitum | genus | A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.[MeSH] | Ranunculaceae | The buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 417761 |
| SCHEMBL ID | 1643265 |
| MeSH ID | M0136694 |
| Synonym |
|---|
| nsc-95098 |
| nsc624741 |
| aconine |
| ethyl-trimethoxy-(methoxymethyl)[?]pentol |
| 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol |
| OPREA1_403193 |
| jesaconine |
| 509-20-6 |
| FT-0688343 |
| SCHEMBL1643265 |
| (3r,4r,6s,7r,7ar,8r,9r,10s,11s,11ar,13r,14s)-1-ethyl-6,10,13-trimethoxy-3-(methoxymethyl)tetradecahydro-1h-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocine-4,8,9,11,11a-pentaol |
| 11-ethyl-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,5,7,8,14-pentol |
| DTXSID60871718 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "This review aims to summarize the pharmacokinetic and pharmacological activities of low-toxicity ADAs, providing a reference for future ADAs research and drug development." | ( A review: Pharmacokinetics and pharmacology of aminoalcohol-diterpenoid alkaloids from Aconitum species. Liu, X; Liu, Y; Meng, X; Tao, H; Tian, R; Zeng, Y; Zhang, Y, 2023) | 0.91 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The potential risk of drug-drug interactions (DDIs) arising from co-administration of Aconitum alkaloids and other drugs against specific targets such as P-glycoprotein (P-gp) must be evaluated." | ( Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug-drug interactions. Feng, L; He, S; Li, F; Li, N; Lin, N; Liu, L; Liu, S; Liu, Z; Lu, L; Ou, R; Wu, J; Zhang, G; Zhu, Y, 2016) | 0.43 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (48.13) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (6.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (93.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||