Page last updated: 2024-12-08

1-methyl-2-(3-pyridyl)azetidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-methyl-2-(3-pyridyl)azetidine, also known as **(3-Pyridyl)methyl-azetidine**, is a **heterocyclic compound** containing both a **pyridine** ring and an **azetidine** ring.

Here's why it's important for research:

* **Potential therapeutic applications:** This compound and its derivatives exhibit various pharmacological activities that make them interesting for drug development. They have been shown to have:
* **Anti-inflammatory effects:** Inhibiting the production of inflammatory mediators.
* **Antioxidant properties:** Protecting cells from damage caused by reactive oxygen species.
* **Anti-cancer activity:** Inhibiting the growth of cancer cells.
* **Central nervous system effects:** Modulating neurotransmission in the brain.
* **Antimicrobial activity:** Targeting bacterial or fungal pathogens.
* **Chemical synthesis and reactivity:** The structure of 1-methyl-2-(3-pyridyl)azetidine makes it a valuable building block for the synthesis of more complex molecules. It can be readily modified through various chemical reactions, leading to a diverse library of compounds with potential therapeutic applications.
* **Understanding structure-activity relationships:** By studying the effects of modifying different functional groups on the azetidine and pyridine rings, researchers can gain insights into the relationship between a molecule's structure and its biological activity. This knowledge is crucial for the design of new and more potent drugs.

**It's important to note that:**

* While 1-methyl-2-(3-pyridyl)azetidine holds promise as a therapeutic agent, further research is necessary to fully understand its safety and efficacy in humans.
* Extensive preclinical and clinical trials are required before any potential drug can be made available for medical use.

**In summary,** 1-methyl-2-(3-pyridyl)azetidine is a fascinating compound with potential therapeutic applications due to its diverse biological activities. Ongoing research is exploring its use as a lead compound for drug development and for studying structure-activity relationships.

1-methyl-2-(3-pyridyl)azetidine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID163827
CHEMBL ID321099
SCHEMBL ID156115
MeSH IDM0150717

Synonyms (12)

Synonym
1-mpatd
CHEMBL321099
3-(1-methylazetidin-2-yl)pyridine
110716-86-4
1-methyl-2-(3-pyridyl)azetidine
pyridine, 3-(1-methyl-2-azetidinyl)-, (+-)-
SCHEMBL156115
AQTJADRDDFZHKK-UHFFFAOYSA-N
n-methyl-2-(3-pyridyl)azetidine
62247-28-3
methyl-2-(3-pyridyl) -azetidine
DTXSID10911835
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID146635Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]bungarotoxin as radioligand1999Journal of medicinal chemistry, Aug-12, Volume: 42, Issue:16
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.
AID147084Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha-7 subtype using [3H]S-(-)-nicotine as radioligand; Not determined1999Journal of medicinal chemistry, Aug-12, Volume: 42, Issue:16
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.09 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]