Page last updated: 2024-09-05

1-methyl-2-(3-pyridyl)azetidine and nicotine

1-methyl-2-(3-pyridyl)azetidine has been researched along with nicotine in 5 studies

Compound Research Comparison

Studies
(1-methyl-2-(3-pyridyl)azetidine)
Trials
(1-methyl-2-(3-pyridyl)azetidine)
Recent Studies (post-2010)
(1-methyl-2-(3-pyridyl)azetidine)
Studies
(nicotine)
Trials
(nicotine)
Recent Studies (post-2010) (nicotine)
50028,5192,2809,302

Protein Interaction Comparison

ProteinTaxonomy1-methyl-2-(3-pyridyl)azetidine (IC50)nicotine (IC50)
Neuronal acetylcholine receptor subunit alpha-4Mus musculus (house mouse)0.0055
Acetylcholine receptor subunit alphaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit betaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit gammaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit deltaTetronarce californica (Pacific electric ray)0.0025
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0046
Neuronal acetylcholine receptor subunit alpha-2Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.0046
Neuronal acetylcholine receptor subunit beta-3Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)0.3256
Neuronal acetylcholine receptor subunit alpha-5Rattus norvegicus (Norway rat)0.005
Acetylcholine receptor subunit beta-like 2Drosophila melanogaster (fruit fly)4
Neuronal acetylcholine receptor subunit beta-4Homo sapiens (human)0.43
Neuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)0.1866
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)7.6
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-9Rattus norvegicus (Norway rat)0.0041
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)0.3456
Neuronal acetylcholine receptor subunit alpha-7Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-3Homo sapiens (human)0.0848
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)0.0087
Neuronal acetylcholine receptor subunit alpha-6Homo sapiens (human)0.0848
Neuronal acetylcholine receptor subunit alpha-5Mus musculus (house mouse)0.004
Liver carboxylesterase B-1Rattus norvegicus (Norway rat)0.045
Neuronal acetylcholine receptor subunit beta-3Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-4Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-3Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-2Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-2Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-10Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-6Mus musculus (house mouse)0.004

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caldwell, WS; Schmitt, JD; Sharples, CG1
Abood, LG; Banerjee, S; Lu, X1
Abood, LG; Kende, AS; Lerner-Marmarosh, N; Wang, DX1
Bergström, M; Bivehed, H; Fasth, KJ; Långström, B; Nordberg, A; Ogren, M; Sihver, W; Watanabe, Y1
Bergström, M; Fasth, KJ; Långström, B; Lundqvist, H; Nordberg, A; Ogren, M; Sihver, W; Watanabe, Y1

Reviews

1 review(s) available for 1-methyl-2-(3-pyridyl)azetidine and nicotine

ArticleYear
Probing ion channels and recognition sites of neuronal nicotinic cholinergic receptors with novel nicotine affinity and other ligands.
    Annals of the New York Academy of Sciences, 1995, May-10, Volume: 757

    Topics: Affinity Labels; Animals; Azetidines; Binding, Competitive; Brain; Brain Mapping; Calcium; Carbachol; Dithiothreitol; GTP-Binding Proteins; Immunologic Techniques; In Vitro Techniques; Ion Channel Gating; Ligands; Mecamylamine; Nicotine; Receptors, Nicotinic

1995

Other Studies

4 other study(ies) available for 1-methyl-2-(3-pyridyl)azetidine and nicotine

ArticleYear
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Amino Acids; Ligands; Models, Molecular; Molecular Conformation; Quantum Theory; Receptors, Nicotinic; Structure-Activity Relationship

1999
Receptor binding characteristics of a 3H-labeled azetidine analogue of nicotine.
    Biochemical pharmacology, 1987, Jul-15, Volume: 36, Issue:14

    Topics: Animals; Azetidines; Azetines; Binding, Competitive; Brain Chemistry; Carbachol; Cell Membrane; Choline; Kinetics; Nicotine; Paralysis; Protein Binding; Psychotropic Drugs; Rats; Receptors, Nicotinic; Thermodynamics

1987
In vitro evaluation of 11C-labeled (S)-nicotine, (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole, and (R,S)-1-methyl-2-(3-pyridyl)azetidine as nicotinic receptor ligands for positron emission tomography studies.
    Journal of neurochemistry, 1998, Volume: 71, Issue:4

    Topics: Animals; Azetidines; Binding Sites; Brain; Carbon Radioisotopes; Isoxazoles; Ligands; Male; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tomography, Emission-Computed

1998
In vivo positron emission tomography studies on the novel nicotinic receptor agonist [11C]MPA compared with [11C]ABT-418 and (S)(-)[11C]nicotine in rhesus monkeys.
    Nuclear medicine and biology, 1999, Volume: 26, Issue:6

    Topics: Animals; Azetidines; Brain; Carbon Radioisotopes; Cerebellum; Isoxazoles; Macaca mulatta; Nicotine; Organ Specificity; Pyrrolidines; Radiopharmaceuticals; Temporal Lobe; Thalamus; Tomography, Emission-Computed

1999