1-deaza-fad profile

**1-Deaza-FAD** is a modified form of the coenzyme flavin adenine dinucleotide (FAD). It differs from FAD in that the nitrogen atom at position 1 of the isoalloxazine ring is replaced with a carbon atom.

**Importance for Research:**

**1. Studies on Flavin-Dependent Enzymes:**

* 1-Deaza-FAD is a potent inhibitor of many flavin-dependent enzymes. It acts by binding to the active site of the enzyme and blocking the normal function of FAD.
* This property makes 1-deaza-FAD a valuable tool for studying the mechanism of flavin-dependent enzymes.
* By inhibiting the enzyme, researchers can identify the role of FAD in the catalytic cycle and gain insights into the enzyme's structure and function.

**2. Elucidating the Role of FAD in Biological Processes:**

* 1-Deaza-FAD can be used as a probe to investigate the role of FAD in various biological processes.
* For example, researchers have used 1-deaza-FAD to study the role of FAD in electron transfer reactions, redox signaling, and DNA repair.

**3. Development of Therapeutics:**

* The inhibitory properties of 1-deaza-FAD have led to its potential use in developing new therapeutic agents.
* For instance, 1-deaza-FAD derivatives have been investigated as potential inhibitors of certain cancer cells.

**Specific Applications:**

* **Enzyme kinetics:** 1-Deaza-FAD is used to determine kinetic parameters of flavin-dependent enzymes.
* **Structural studies:** It can be used to crystallize flavin-dependent enzymes in complex with the inhibitor, providing insights into the active site structure.
* **Drug discovery:** 1-Deaza-FAD serves as a lead compound for the development of novel drugs that target flavin-dependent enzymes.

**Overall, 1-deaza-FAD is a versatile tool in research, providing insights into the function of flavin-dependent enzymes, facilitating the development of therapeutics, and advancing our understanding of fundamental biological processes.**

1-deaza-FAD: RN & N1 from 9th CI Form Index; cpd not in Chemline 7/14/83 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	194041
MeSH ID	M0080640

Synonym
deazafad
57818-88-9
[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2r,3s,4s)-5-(7,8-dimethyl-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate
1-deaza-fad
adenosine 5'-(trihydrogen diphosphate), 5-5'-ester with 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxopyrimido(4,5-b)quinolin-10(2h)-yl)-d-ribitol
5-deazariboflavin-5'-diphosphate
AKOS040749896

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (37.50)	18.7374
1990's	3 (18.75)	18.2507
2000's	7 (43.75)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dithionite Dithionite: Dithionite. The dithionous acid ion and its salts.	2.66	3	sulfur oxide; sulfur oxoanion
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	2.01	1	bipyridine	chelator; ferroptosis inhibitor
galactose galactopyranose : The pyranose form of galactose.	2.01	1	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
valine Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.	2.01	1	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
threonine Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.	2.01	1	amino acid zwitterion; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid; threonine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
galactose aldohexose : A hexose with a (potential) aldehyde group at one end.	2.01	1
iodonitrotetrazolium iodonitrotetrazolium chloride : An organic chloride salt having iodonitrotetrazolium as the counterion.. iodonitrotetrazolium : An organic cation that is the cationic component of iodonitrotetrazolium violet.	2.01	1	organic chloride salt	histological dye
1-benzylimidazole 1-benzylimidazole: inhibits human thromboxane synthetase	2.01	1
5-deaza-fmn [no description available]	1.95	1
benzylamphetamine norbenzphetamine: RN given refers to parent cpd; structure	2.01	1
butyryl-coenzyme a [no description available]	1.96	1	butanoyl-CoAs	Escherichia coli metabolite; mouse metabolite
singlet oxygen Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.	2.01	1	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient
5-deazariboflavin 5-deazariboflavin: deaza analog of riboflavin used to elucidate chemical role of the flavin coenzyme; structure	1.95	1
8-chloro-fad [no description available]	2.02	1
riboflavin vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).	1.95	1	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite
flavin-adenine dinucleotide Flavin-Adenine Dinucleotide: A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)	4.12	16	flavin adenine dinucleotide; vitamin B2	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; prosthetic group
nadp [no description available]	2.36	2
benzphetamine Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222). benzphetamine : Dextroamphetamine in which the the hydrogens attached to the amino group are substituted by a methyl and a benzyl group. A sympathomimetic agent with properties similar to dextroamphetamine, it is used as its hydrochloride salt in the treatment of obesity.	2.01	1	amphetamines; tertiary amine	adrenergic uptake inhibitor; appetite depressant; dopamine uptake inhibitor; sympathomimetic agent
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.43	2	cysteinium	fundamental metabolite
crotonyl-coenzyme a crotonoyl-CoA : The (E)-isomer of but-2-enoyl-CoA.	1.96	1	but-2-enoyl-CoA
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	1.96	1	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	2.01	1
dicumarol Dicumarol: An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.	1.98	1	hydroxycoumarin	anticoagulant; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; Hsp90 inhibitor; vitamin K antagonist
flavin mononucleotide Flavin Mononucleotide: A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.	2.66	3

1-deaza-fad

Description

Cross-References

Synonyms (7)

Research

Studies (16)

Market Indicators

Research Demand Index: 11.67

Study Types