1,3-dipalmitoyl-2-phosphatidylcholine profile

Also known as DPPC, is a phospholipid commonly found in the cell membranes of animals and plants. It is a saturated phospholipid, meaning that its fatty acid chains are fully hydrogenated and contain no double bonds. This gives DPPC a rigid structure and a high melting point. DPPC is often used as a model system for studying the behavior of phospholipids in biological membranes. It is also used as a component of liposomes, which are small vesicles that can encapsulate drugs and other molecules for therapeutic purposes. DPPC is commercially available and is widely used in research and industry, for example, in the study of biomembranes, development of drug delivery systems, and development of synthetic membranes. DPPC is an important component of lung surfactant, a mixture of lipids and proteins that lines the alveoli in the lungs. Lung surfactant helps to reduce surface tension in the alveoli, preventing them from collapsing during exhalation. DPPC deficiency can lead to respiratory distress syndrome (RDS), a serious lung condition that is most common in premature infants.'

1,3-dipalmitoyl-2-phosphatidylcholine: the 1,2-isomer is a main heading, 1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	94589
SCHEMBL ID	4663586
MeSH ID	M0118393

Synonym
1,3-dipalmitoyl-glycero-2-phosphocholine
D-6053
(4-oxido-9-oxo-6-(palmitoylmethyl)-3,5,8-trioxa-4-phosphatetracosyl)trimethylammonium 4-oxide
59540-22-6
1,3-di(hexadecanoyloxy)propan-2-yl 2-(trimethylazaniumyl)ethyl phosphate
einecs 261-800-5
1,3-dipalmitoyl-2-phosphatidylcholine
3,5,8-trioxa-4-phosphatetracosan-1-aminium, 4-hydroxy-n,n,n-trimethyl-9-oxo-6-(((1-oxohexadecyl)oxy)methyl)-, hydroxide, inner salt, 4-oxide
FT-0621701
SCHEMBL4663586
DTXSID40208225
[4-oxido-9-oxo-6-(palmitoylmethyl)-3,5,8-trioxa-4-phosphatetracosyl]trimethylammonium 4-oxide

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (52.63)	18.7374
1990's	3 (15.79)	18.2507
2000's	1 (5.26)	29.6817
2010's	5 (26.32)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.26%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (94.74%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.11	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	1.96	1	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
dipalmitoylphosphatidic acid dipalmitoylphosphatidic acid: RN given refers to parent cpd without isomeric designation. dihexadecanoyl phosphatidic acid : A phosphatidic acid in which the phosphatidyl acyl groups are both palmitoyl (hexadecanoyl).	1.96	1	phosphatidic acid
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	1.96	1
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	1.96	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
1,2-dipalmitoylphosphatidylcholine 1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	5.39	19
chrysotile Asbestos, Serpentine: A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)	1.97	1
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.11	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
substance p [no description available]	1.98	1	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent
fluorexon fluorexon: structure	1.96	1	xanthene dye	fluorochrome
1,2-dipalmitoyl-3-phosphatidylethanolamine 1,2-dipalmitoyl-3-phosphatidylethanolamine: RN given refers to parent cpd without isomeric designation	3.21	1
1,2-dipalmitoylphosphatidylglycerol dipalmitoyl phosphatidylglycerol : A phosphatidylglycerol in which the phosphatidyl acyl groups are both palmitoyl.	1.96	1	phosphatidylglycerol
we 201 We 201: synthetic lysolecithin analog; RN given refers to hydroxide inner salt; structure	2.37	2
ergosterol [no description available]	2.11	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
lysophosphatidylcholines lysophosphatidylcholine : An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.	2.37	2	1-O-acyl-sn-glycero-3-phosphocholine
diphenylhexatriene Diphenylhexatriene: A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.	1.97	1	alkatriene	fluorochrome
dimyristoylphosphatidylcholine 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).	2.37	2	1,2-diacyl-sn-glycero-3-phosphocholine; phosphatidylcholine 28:0; tetradecanoate ester	antigen; mouse metabolite
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	1.97	1	carbon group element atom; metalloid atom; nonmetal atom
dehydroergosterol dehydroergosterol : A phytosterol consiting of ergostane having double bonds at the 5,6-, 7,8- 9,11- and 22,23-positions as well as a 3beta-hydroxy group.	2.11	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	biomarker; metabolite
artenimol artenimol: derivative of antimalarial drug artemisinin (quinghaosu)	2.11	1
scopolamine hydrobromide [no description available]	1.96	1
melitten Melitten: Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.	1.96	1
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	3.47	8	1,2-diacyl-sn-glycero-3-phosphocholine
glycolipids [no description available]	2.11	1
asbestos, crocidolite Asbestos, Crocidolite: A lavender, acid-resistant asbestos.	1.97	1
delta hemolysin protein, staphylococcus aureus delta hemolysin protein, Staphylococcus aureus: membrane-damaging peptide of 26 residues from Staph aureus	1.96	1

Condition	Relationship Strength	Studies
Polyarthritis [description not available]	2.11	1
Arthritis Acute or chronic inflammation of JOINTS.	2.11	1
Labor, Premature [description not available]	1.96	1
Infantile Respiratory Distress Syndrome [description not available]	1.96	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.96	1
Respiratory Distress Syndrome, Newborn A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.	1.96	1
Extravascular Hemolysis [description not available]	1.96	1
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	1.96	1

1,3-dipalmitoyl-2-phosphatidylcholine

Description

Cross-References

Synonyms (12)

Research

Studies (19)

Market Indicators

Research Demand Index: 11.20

Study Types