Page last updated: 2024-12-11
manoalogue
Description
manoalogue: synthetic analog of manoalide; phospholipase A2 antagonist; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 6438691 |
| MeSH ID | M0192367 |
Synonyms (9)
| Synonym |
|---|
| manoalogue |
| (2e,4e)-2-[3-(2-hydroxy-5-oxo-2h-furan-3-yl)propylidene]-5,9-dimethyldeca-4,8-dienal |
| bdbm92677 |
| 136440-42-1 |
| unii-9y87o3147p |
| 4,8-decadienal, 2-(3-(2,5-dihydro-2-hydroxy-5-oxo-3-furanyl)propylidene)5,9-dimethyl-, (e,e)- |
| 9y87o3147p , |
| 4,8-decadienal, 2-(3-(2,5-dihydro-2-hydroxy-5-oxo-3-furanyl)propylidene)-5,9-dimethyl-, (2e,4e)- |
| Q27273380 |
Research Excerpts
Treatment
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|
| Phospholipase A2 | Homo sapiens (human) | IC50 (µMol) | 26.0000 | 0.0030 | 0.9122 | 3.9000 | AID1799820 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Biological Processes (29)
Molecular Functions (6)
Ceullar Components (3)
Bioassays (1)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1799820 | Phospholipase A2 Vesicle Assay from Article : \\Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, a | 1989 | The Journal of biological chemistry, May-25, Volume: 264, Issue:15
| Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |