Page last updated: 2024-12-11

manoalogue

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

manoalogue: synthetic analog of manoalide; phospholipase A2 antagonist; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6438691
MeSH IDM0192367

Synonyms (9)

Synonym
manoalogue
(2e,4e)-2-[3-(2-hydroxy-5-oxo-2h-furan-3-yl)propylidene]-5,9-dimethyldeca-4,8-dienal
bdbm92677
136440-42-1
unii-9y87o3147p
4,8-decadienal, 2-(3-(2,5-dihydro-2-hydroxy-5-oxo-3-furanyl)propylidene)5,9-dimethyl-, (e,e)-
9y87o3147p ,
4,8-decadienal, 2-(3-(2,5-dihydro-2-hydroxy-5-oxo-3-furanyl)propylidene)-5,9-dimethyl-, (2e,4e)-
Q27273380

Research Excerpts

Treatment

ExcerptReferenceRelevance
"Manoalogue-treated enzymes were examined in the scooting mode on vesicles of 1,2-dimyristoyl-sn-glycero-3-phosphomethanol."( Kinetic characterization of phospholipase A2 modified by manoalogue.
Gelb, MH; Ghomashchi, F; Jain, MK; Mihelich, ED; Yu, BZ, 1991
)
1.25
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Phospholipase A2Homo sapiens (human)IC50 (µMol)26.00000.00300.91223.9000AID1799820
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (29)

Processvia Protein(s)Taxonomy
positive regulation of interleukin-8 productionPhospholipase A2Homo sapiens (human)
positive regulation of MAP kinase activityPhospholipase A2Homo sapiens (human)
innate immune response in mucosaPhospholipase A2Homo sapiens (human)
neutrophil mediated immunityPhospholipase A2Homo sapiens (human)
fatty acid biosynthetic processPhospholipase A2Homo sapiens (human)
actin filament organizationPhospholipase A2Homo sapiens (human)
signal transductionPhospholipase A2Homo sapiens (human)
positive regulation of cell population proliferationPhospholipase A2Homo sapiens (human)
positive regulation of calcium ion transport into cytosolPhospholipase A2Homo sapiens (human)
lipid catabolic processPhospholipase A2Homo sapiens (human)
leukotriene biosynthetic processPhospholipase A2Homo sapiens (human)
antibacterial humoral responsePhospholipase A2Homo sapiens (human)
neutrophil chemotaxisPhospholipase A2Homo sapiens (human)
activation of phospholipase A2 activityPhospholipase A2Homo sapiens (human)
cellular response to insulin stimulusPhospholipase A2Homo sapiens (human)
intracellular signal transductionPhospholipase A2Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIPhospholipase A2Homo sapiens (human)
regulation of glucose importPhospholipase A2Homo sapiens (human)
phosphatidylcholine metabolic processPhospholipase A2Homo sapiens (human)
phosphatidylglycerol metabolic processPhospholipase A2Homo sapiens (human)
positive regulation of fibroblast proliferationPhospholipase A2Homo sapiens (human)
arachidonic acid secretionPhospholipase A2Homo sapiens (human)
positive regulation of protein secretionPhospholipase A2Homo sapiens (human)
positive regulation of immune responsePhospholipase A2Homo sapiens (human)
defense response to Gram-positive bacteriumPhospholipase A2Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activityPhospholipase A2Homo sapiens (human)
antimicrobial humoral immune response mediated by antimicrobial peptidePhospholipase A2Homo sapiens (human)
positive regulation of podocyte apoptotic processPhospholipase A2Homo sapiens (human)
phospholipid metabolic processPhospholipase A2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
phospholipase A2 activityPhospholipase A2Homo sapiens (human)
signaling receptor bindingPhospholipase A2Homo sapiens (human)
calcium ion bindingPhospholipase A2Homo sapiens (human)
bile acid bindingPhospholipase A2Homo sapiens (human)
calcium-dependent phospholipase A2 activityPhospholipase A2Homo sapiens (human)
phospholipid bindingPhospholipase A2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
extracellular regionPhospholipase A2Homo sapiens (human)
extracellular spacePhospholipase A2Homo sapiens (human)
cell surfacePhospholipase A2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1799820Phospholipase A2 Vesicle Assay from Article : \\Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, a1989The Journal of biological chemistry, May-25, Volume: 264, Issue:15
Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]