manoalogue: synthetic analog of manoalide; phospholipase A2 antagonist; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
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PubMed CID | 6438691 |
MeSH ID | M0192367 |
Synonym |
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manoalogue |
(2e,4e)-2-[3-(2-hydroxy-5-oxo-2h-furan-3-yl)propylidene]-5,9-dimethyldeca-4,8-dienal |
bdbm92677 |
136440-42-1 |
unii-9y87o3147p |
4,8-decadienal, 2-(3-(2,5-dihydro-2-hydroxy-5-oxo-3-furanyl)propylidene)5,9-dimethyl-, (e,e)- |
9y87o3147p , |
4,8-decadienal, 2-(3-(2,5-dihydro-2-hydroxy-5-oxo-3-furanyl)propylidene)-5,9-dimethyl-, (2e,4e)- |
Q27273380 |
Excerpt | Reference | Relevance |
---|---|---|
"Manoalogue-treated enzymes were examined in the scooting mode on vesicles of 1,2-dimyristoyl-sn-glycero-3-phosphomethanol." | ( Kinetic characterization of phospholipase A2 modified by manoalogue. Gelb, MH; Ghomashchi, F; Jain, MK; Mihelich, ED; Yu, BZ, 1991) | 1.25 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Phospholipase A2 | Homo sapiens (human) | IC50 (µMol) | 26.0000 | 0.0030 | 0.9122 | 3.9000 | AID1799820 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
phospholipase A2 activity | Phospholipase A2 | Homo sapiens (human) |
signaling receptor binding | Phospholipase A2 | Homo sapiens (human) |
calcium ion binding | Phospholipase A2 | Homo sapiens (human) |
bile acid binding | Phospholipase A2 | Homo sapiens (human) |
calcium-dependent phospholipase A2 activity | Phospholipase A2 | Homo sapiens (human) |
phospholipid binding | Phospholipase A2 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
extracellular region | Phospholipase A2 | Homo sapiens (human) |
extracellular space | Phospholipase A2 | Homo sapiens (human) |
cell surface | Phospholipase A2 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1799820 | Phospholipase A2 Vesicle Assay from Article : \\Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, a | 1989 | The Journal of biological chemistry, May-25, Volume: 264, Issue:15 | Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (20.00) | 18.7374 |
1990's | 4 (80.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |