HTS 01037 profile

ID Source	ID
PubMed CID	5714537
CHEMBL ID	1077990
CHEBI ID	186187
SCHEMBL ID	13720444

Synonym
SR-01000632936-1
4-{[2-(methoxycarbonyl)-5-(2-thienyl)-3-thienyl]amino}-4-oxo-2-butenoic acid
smr000456057
MLS000850039
4-{[2-methoxycarbonyl)-5-(2-thienyl)-3-thienyl]amino}-4-oxo-2-butenoic acid
bdbm50310988
CHEMBL1077990 ,
CHEBI:186187
hts 01037
(e)-4-[(2-methoxycarbonyl-5-thiophen-2-ylthiophen-3-yl)amino]-4-oxobut-2-enoic acid
CCG-42982
compound 1 [pmid: 19754198]
hts01037
gtpl6736
SCHEMBL13720444
682741-29-3
CS-6858
HY-101503
Q27077997
MS-25116
AKOS040741846

Class	Description
ring assembly	Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved.
thiophenes	Compounds containing at least one thiophene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	15.8114	0.1409	11.1940	39.8107	AID2451
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	39.8107	0.1778	14.3909	39.8107	AID2147
T cell receptor, partial	Homo sapiens (human)	Potency	5.6007	0.9960	3.6401	6.2841	AID624298
Nrf2	Homo sapiens (human)	Potency	15.8489	0.0920	8.2222	23.1093	AID624171
glp-1 receptor, partial	Homo sapiens (human)	Potency	1.9953	0.0184	6.8060	14.1254	AID624417
chaperonin-containing TCP-1 beta subunit homolog	Homo sapiens (human)	Potency	31.6228	3.9811	27.7649	39.8107	AID504842
TDP1 protein	Homo sapiens (human)	Potency	18.8452	0.0008	11.3822	44.6684	AID686978; AID686979
IDH1	Homo sapiens (human)	Potency	29.0929	0.0052	10.8652	35.4813	AID686970
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	15.8489	0.5406	17.6392	96.1227	AID2528
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	17.7828	0.3548	28.0659	89.1251	AID504847
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	44.6684	3.5481	19.5427	44.6684	AID743266
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	0.4611	5.8048	36.1306	65.1308	AID540253
snurportin-1	Homo sapiens (human)	Potency	0.4611	5.8048	36.1306	65.1308	AID540253
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	7.0795	0.0103	23.8567	63.0957	AID2662
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	0.4611	5.8048	16.9962	25.9290	AID540253
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	35.4813	0.0079	8.2332	1,122.0200	AID2546
geminin	Homo sapiens (human)	Potency	29.0929	0.0046	11.3741	33.4983	AID624296; AID624297
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	22.3872	0.0041	9.9625	28.1838	AID2675
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	22.4635	0.0580	10.6949	26.6086	AID602310; AID651813
DNA dC->dU-editing enzyme APOBEC-3F isoform a	Homo sapiens (human)	Potency	14.0441	0.0259	11.2398	31.6228	AID651815
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	3.1623	0.0158	12.3113	615.5000	AID1461
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	22.3872	1.9953	25.5327	50.1187	AID624288
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Fatty acid-binding protein, heart	Homo sapiens (human)	Ki	9.0700	0.2500	5.9080	9.3000	AID468320
Fatty acid-binding protein, liver	Homo sapiens (human)	Ki	8.1700	0.0150	1.4770	8.1700	AID468322
Fatty acid-binding protein, intestinal	Homo sapiens (human)	Ki	6.5700	0.3000	5.4814	9.4000	AID468321
Fatty acid-binding protein, adipocyte	Homo sapiens (human)	Ki	0.6700	0.0020	0.9291	6.8000	AID468318
Fatty acid-binding protein 5	Homo sapiens (human)	Ki	3.4000	0.2480	2.7712	9.3700	AID468319
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
recombinase A	Mycobacterium tuberculosis H37Rv	EC50 (µMol)	54.4800	0.0180	23.2882	287.6000	AID434968; AID435010
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
replicative DNA helicase	Mycobacterium tuberculosis H37Rv	AC50	59.3750	0.0570	30.7482	325.3000	AID449749; AID449750
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of cell population proliferation	Fatty acid-binding protein, heart	Homo sapiens (human)
long-chain fatty acid transport	Fatty acid-binding protein, heart	Homo sapiens (human)
intracellular lipid transport	Fatty acid-binding protein, heart	Homo sapiens (human)
cholesterol homeostasis	Fatty acid-binding protein, heart	Homo sapiens (human)
regulation of fatty acid oxidation	Fatty acid-binding protein, heart	Homo sapiens (human)
brown fat cell differentiation	Fatty acid-binding protein, heart	Homo sapiens (human)
phospholipid homeostasis	Fatty acid-binding protein, heart	Homo sapiens (human)
positive regulation of phospholipid biosynthetic process	Fatty acid-binding protein, heart	Homo sapiens (human)
positive regulation of long-chain fatty acid import into cell	Fatty acid-binding protein, heart	Homo sapiens (human)
regulation of phosphatidylcholine biosynthetic process	Fatty acid-binding protein, heart	Homo sapiens (human)
long-chain fatty acid transport	Fatty acid-binding protein, liver	Homo sapiens (human)
positive regulation of fatty acid beta-oxidation	Fatty acid-binding protein, liver	Homo sapiens (human)
response to vitamin B3	Fatty acid-binding protein, liver	Homo sapiens (human)
negative regulation of apoptotic process	Fatty acid-binding protein, liver	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Fatty acid-binding protein, liver	Homo sapiens (human)
intestinal absorption	Fatty acid-binding protein, liver	Homo sapiens (human)
cellular response to hydrogen peroxide	Fatty acid-binding protein, liver	Homo sapiens (human)
cellular response to hypoxia	Fatty acid-binding protein, liver	Homo sapiens (human)
cellular oxidant detoxification	Fatty acid-binding protein, liver	Homo sapiens (human)
fatty acid transport	Fatty acid-binding protein, liver	Homo sapiens (human)
fatty acid metabolic process	Fatty acid-binding protein, intestinal	Homo sapiens (human)
long-chain fatty acid transport	Fatty acid-binding protein, intestinal	Homo sapiens (human)
intestinal lipid absorption	Fatty acid-binding protein, intestinal	Homo sapiens (human)
fatty acid transport	Fatty acid-binding protein, intestinal	Homo sapiens (human)
response to bacterium	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
long-chain fatty acid transport	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
cholesterol homeostasis	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
negative regulation of DNA-templated transcription	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
positive regulation of inflammatory response	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
white fat cell differentiation	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
brown fat cell differentiation	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
cellular response to lithium ion	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
cellular response to tumor necrosis factor	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
fatty acid transport	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
renal water homeostasis	Guanine nucleotide-binding protein G	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G	Homo sapiens (human)
regulation of insulin secretion	Guanine nucleotide-binding protein G	Homo sapiens (human)
cellular response to glucagon stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
glucose metabolic process	Fatty acid-binding protein 5	Homo sapiens (human)
lipid metabolic process	Fatty acid-binding protein 5	Homo sapiens (human)
phosphatidylcholine biosynthetic process	Fatty acid-binding protein 5	Homo sapiens (human)
epidermis development	Fatty acid-binding protein 5	Homo sapiens (human)
negative regulation of glucose transmembrane transport	Fatty acid-binding protein 5	Homo sapiens (human)
long-chain fatty acid transport	Fatty acid-binding protein 5	Homo sapiens (human)
regulation of prostaglandin biosynthetic process	Fatty acid-binding protein 5	Homo sapiens (human)
positive regulation of peroxisome proliferator activated receptor signaling pathway	Fatty acid-binding protein 5	Homo sapiens (human)
glucose homeostasis	Fatty acid-binding protein 5	Homo sapiens (human)
regulation of sensory perception of pain	Fatty acid-binding protein 5	Homo sapiens (human)
regulation of retrograde trans-synaptic signaling by endocanabinoid	Fatty acid-binding protein 5	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Fatty acid-binding protein 5	Homo sapiens (human)
lipid transport across blood-brain barrier	Fatty acid-binding protein 5	Homo sapiens (human)
fatty acid transport	Fatty acid-binding protein 5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
protein binding	Fatty acid-binding protein, heart	Homo sapiens (human)
cytoskeletal protein binding	Fatty acid-binding protein, heart	Homo sapiens (human)
long-chain fatty acid binding	Fatty acid-binding protein, heart	Homo sapiens (human)
oleic acid binding	Fatty acid-binding protein, heart	Homo sapiens (human)
chromatin binding	Fatty acid-binding protein, liver	Homo sapiens (human)
long-chain fatty acid transmembrane transporter activity	Fatty acid-binding protein, liver	Homo sapiens (human)
protein binding	Fatty acid-binding protein, liver	Homo sapiens (human)
phospholipid binding	Fatty acid-binding protein, liver	Homo sapiens (human)
antioxidant activity	Fatty acid-binding protein, liver	Homo sapiens (human)
bile acid binding	Fatty acid-binding protein, liver	Homo sapiens (human)
oleic acid binding	Fatty acid-binding protein, liver	Homo sapiens (human)
heterocyclic compound binding	Fatty acid-binding protein, liver	Homo sapiens (human)
fatty acid binding	Fatty acid-binding protein, liver	Homo sapiens (human)
long-chain fatty acid transmembrane transporter activity	Fatty acid-binding protein, intestinal	Homo sapiens (human)
fatty acid binding	Fatty acid-binding protein, intestinal	Homo sapiens (human)
protein binding	Fatty acid-binding protein, intestinal	Homo sapiens (human)
long-chain fatty acid binding	Fatty acid-binding protein, intestinal	Homo sapiens (human)
long-chain fatty acid transmembrane transporter activity	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
long-chain fatty acid binding	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
hormone receptor binding	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
fatty acid binding	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
G protein activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
adenylate cyclase activator activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
retinoic acid binding	Fatty acid-binding protein 5	Homo sapiens (human)
long-chain fatty acid transmembrane transporter activity	Fatty acid-binding protein 5	Homo sapiens (human)
fatty acid binding	Fatty acid-binding protein 5	Homo sapiens (human)
protein binding	Fatty acid-binding protein 5	Homo sapiens (human)
lipid binding	Fatty acid-binding protein 5	Homo sapiens (human)
identical protein binding	Fatty acid-binding protein 5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular space	Fatty acid-binding protein, heart	Homo sapiens (human)
cytosol	Fatty acid-binding protein, heart	Homo sapiens (human)
extracellular exosome	Fatty acid-binding protein, heart	Homo sapiens (human)
nucleus	Fatty acid-binding protein, heart	Homo sapiens (human)
cytosol	Fatty acid-binding protein, heart	Homo sapiens (human)
nucleoplasm	Fatty acid-binding protein, liver	Homo sapiens (human)
peroxisomal matrix	Fatty acid-binding protein, liver	Homo sapiens (human)
cytosol	Fatty acid-binding protein, liver	Homo sapiens (human)
apical cortex	Fatty acid-binding protein, liver	Homo sapiens (human)
extracellular exosome	Fatty acid-binding protein, liver	Homo sapiens (human)
protein-containing complex	Fatty acid-binding protein, liver	Homo sapiens (human)
nucleus	Fatty acid-binding protein, liver	Homo sapiens (human)
cytosol	Fatty acid-binding protein, liver	Homo sapiens (human)
cytosol	Fatty acid-binding protein, intestinal	Homo sapiens (human)
microvillus	Fatty acid-binding protein, intestinal	Homo sapiens (human)
apical cortex	Fatty acid-binding protein, intestinal	Homo sapiens (human)
cytosol	Fatty acid-binding protein, intestinal	Homo sapiens (human)
nucleus	Fatty acid-binding protein, intestinal	Homo sapiens (human)
nucleus	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
cytoplasm	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
lipid droplet	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
cytosol	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
extracellular exosome	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
cytosol	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
nucleus	Fatty acid-binding protein, adipocyte	Homo sapiens (human)
plasma membrane	Guanine nucleotide-binding protein G	Homo sapiens (human)
extracellular region	Fatty acid-binding protein 5	Homo sapiens (human)
nucleus	Fatty acid-binding protein 5	Homo sapiens (human)
nucleoplasm	Fatty acid-binding protein 5	Homo sapiens (human)
cytoplasm	Fatty acid-binding protein 5	Homo sapiens (human)
cytosol	Fatty acid-binding protein 5	Homo sapiens (human)
plasma membrane	Fatty acid-binding protein 5	Homo sapiens (human)
postsynaptic density	Fatty acid-binding protein 5	Homo sapiens (human)
secretory granule membrane	Fatty acid-binding protein 5	Homo sapiens (human)
azurophil granule lumen	Fatty acid-binding protein 5	Homo sapiens (human)
synapse	Fatty acid-binding protein 5	Homo sapiens (human)
extracellular exosome	Fatty acid-binding protein 5	Homo sapiens (human)
cytosol	Fatty acid-binding protein 5	Homo sapiens (human)
nucleus	Fatty acid-binding protein 5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (35)

Assay ID	Title	Year	Journal	Article
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID468321	Displacement of radiolabeled 1-anilinonaphthalene 8-sulfonic acid from IFABP expressed in Escherichia coli BL21 (DE3) by fluorescence spectrophotometry	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468324	Binding affinity to AFABP in forskolin-stimulated human C8PA cells assessed as blocked of protein interaction with hormone sensitive lipase at 1 uM after 2 to 4 hrs by FRET analysis	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468319	Displacement of radiolabeled 1-anilinonaphthalene 8-sulfonic acid from EFABP expressed in Escherichia coli BL21 (DE3) by fluorescence spectrophotometry	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468327	Inhibition of AFABP-mediated lipolysis in mouse 3T3L1 cells assessed as reduction in non-esterified fatty acid efflux after 24 hrs	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468329	Antiinflammatory activity in C57BL/6J mouse macrophages assessed as inhibition of LPS-stimulated IL6 release pretreated for 48 hrs before LPS challenge measured after 24 hrs by ELISA	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468323	Binding affinity to AFABP in human C8PA cells assessed as blocked of protein interaction with hormone sensitive lipase at 1 uM after 2 to 4 hrs by FRET analysis	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468333	Selectivity ratio of Ki(app) for HFABP to Ki(app) for AFABP	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468337	Binding affinity to PPARgamma in C57BL/6J mouse macrophages assessed as increase in Cpt1alpha mRNA level at 500 nM after 48 hrs by real-time PCR analysis	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468332	Selectivity ratio of Ki(app) for EFABP to Ki(app) for AFABP	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468322	Displacement of radiolabeled 1-anilinonaphthalene 8-sulfonic acid from LFABP expressed in Escherichia coli BL21 (DE3) by fluorescence spectrophotometry	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468328	Inhibition of AFABP-mediated lipolysis in forskolin-stimulated mouse 3T3L1 cells assessed as reduction in non-esterified fatty acid efflux after 24 hrs	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468320	Displacement of radiolabeled 1-anilinonaphthalene 8-sulfonic acid from HFABP expressed in Escherichia coli BL21 (DE3) by fluorescence spectrophotometry	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468339	Activation of PPARgamma expressed in african green monkey CV1 cells at 0.5 to 25 uM after 24 hrs by luciferase reporter gene assay	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468336	Binding affinity to PPARgamma in C57BL/6J mouse macrophages assessed as increase in CD36 mRNA level at 500 nM after 48 hrs by real-time PCR analysis	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468318	Displacement of radiolabeled 1-anilinonaphthalene 8-sulfonic acid from AFABP expressed in Escherichia coli BL21 (DE3) by fluorescence spectrophotometry	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468330	Antiinflammatory activity in C57BL/6J mouse macrophages assessed as inhibition of LPS-stimulated TNFalpha release pretreated for 48 hrs before LPS challenge measured after 24 hrs by ELISA	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468331	Antiinflammatory activity in C57BL/6J mouse macrophages assessed as inhibition of LPS-stimulated MCP1 release pretreated for 48 hrs before LPS challenge measured after 24 hrs by ELISA	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468326	Binding affinity to AFABP in forskolin-stimulated human C8PA cells assessed as blocked of protein interaction with hormone sensitive lipase at 10 uM after 2 to 4 hrs by FRET analysis	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468338	Activation of PPARgamma expressed in african green monkey CV1 cells at 0.5 uM after 24 hrs by luciferase reporter gene assay	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID468325	Binding affinity to AFABP in human C8PA cells assessed as blocked of protein interaction with hormone sensitive lipase at 10 uM after 2 to 4 hrs by FRET analysis	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID1345919	Mouse fatty acid binding protein 1 (Fatty acid-binding proteins)	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
AID1346013	Mouse fatty acid binding protein 4 (Fatty acid-binding proteins)	2009	Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19	Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (33.33)	29.6817
2010's	3 (50.00)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.46	2	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.46	2	0

HTS 01037

Cross-References

Synonyms (21)

Drug Classes (2)

Protein Targets (29)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (44)

Molecular Functions (17)

Ceullar Components (17)

Bioassays (35)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.41

Study Types

HTS 01037

Cross-References

Synonyms (21)

Drug Classes (2)

Protein Targets (29)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (44)

Molecular Functions (17)

Ceullar Components (17)

Bioassays (35)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.41

Study Types

Related Drugs (1)

Related Conditions (2)