| Assay ID | Title | Year | Journal | Article |
|---|
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1995 | Biochemistry, Jul-18, Volume: 34, Issue:28
| Transition state analogue L-leucinephosphonic acid bound to bovine lens leucine aminopeptidase: X-ray structure at 1.65 A resolution in a new crystal form. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1995 | Biochemistry, Jul-18, Volume: 34, Issue:28
| Transition state analogue L-leucinephosphonic acid bound to bovine lens leucine aminopeptidase: X-ray structure at 1.65 A resolution in a new crystal form. |
| AID1162776 | Inhibition of Neisseria meningitidis recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. |
| AID573046 | Antimalarial activity against Plasmodium falciparum 3D7 infected in O-positive human erythrocytes assessed as growth inhibition by LDH assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors. |
| AID573051 | Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 at 10 uM using Leu-AMC as a substrate by spectrophotometer in presence of 1 nM CoCl2 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors. |
| AID573052 | Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 at 0.1 uM using Leu-AMC as a substrate by spectrophotometer in presence of 1 nM CoCl2 | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors. |
| AID1162777 | Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. |
| AID573045 | Antimalarial activity against Plasmodium falciparum 3D7 infected in O-positive human erythrocytes after 72 hrs | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors. |
| AID573047 | Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 at 10 uM using Leu-AMC as a substrate by spectrophotometer | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors. |
| AID1162779 | Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. |
| AID1162778 | Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation | 2014 | Journal of medicinal chemistry, Oct-09, Volume: 57, Issue:19
| Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. |
| AID573049 | Inhibition of alanyl aminopeptidase activity in Plasmodium falciparum 3D7 at 10 uM using Ala-AMC as a substrate by spectrophotometer | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors. |
| AID1314018 | Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric method | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
| Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. |
| AID573050 | Inhibition of alanyl aminopeptidase activity in Plasmodium falciparum 3D7 at 0.1 uM using Ala-AMC as a substrate by spectrophotometer | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors. |
| AID573048 | Inhibition of leucyl aminopeptidase activity in Plasmodium falciparum 3D7 at 0.1 uM using Leu-AMC as a substrate by spectrophotometer | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors. |
| AID101210 | Inhibition of Leucine aminopeptidase isolated from porcine kidney. | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase. |
| AID1314019 | Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
| Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |