Z 335: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 23669776 |
| SCHEMBL ID | 1652950 |
| MeSH ID | M0297450 |
| Synonym |
|---|
| 1h-indene-5-acetic acid, 2-((((4-chlorophenyl)sulfonyl)amino)methyl)-2,3-dihydro-, monosodium salt |
| z-335 |
| sodium 2-((((4-chlorophenyl)sulfonyl)amino)methyl)-2,3-dihydro-1h-indene-5-acetate |
| z 335 |
| 146731-14-8 |
| SCHEMBL1652950 |
| z335 |
| sodium;2-[2-[[(4-chlorophenyl)sulfonylamino]methyl]-2,3-dihydro-1h-inden-5-yl]acetate |
| sodium (2-{[(4-chlorobenzene-1-sulfonyl)amino]methyl}-2,3-dihydro-1h-inden-5-yl)acetate |
| DTXSID20932899 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Serial blood and urine samples were analyzed for Z-335 and its metabolites to obtain key pharmacokinetic parameters." | ( Pharmacokinetic and pharmacodynamic properties of a new thromboxane receptor antagonist (Z-335) after single and multiple oral administrations to healthy volunteers. Kanamaru, M; Kato, H; Kawabata, Y; Kohno, K; Kozawa, O; Matsuno, H; Nagashima, S; Niwa, M; Uematsu, T; Yoshida, Y, 2002) | 0.31 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Thromboxane A2 receptor | Homo sapiens (human) | IC50 (µMol) | 0.3600 | 0.0011 | 0.7106 | 5.2000 | AID224471 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| thromboxane A2 receptor activity | Thromboxane A2 receptor | Homo sapiens (human) |
| guanyl-nucleotide exchange factor activity | Thromboxane A2 receptor | Homo sapiens (human) |
| protein binding | Thromboxane A2 receptor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| acrosomal vesicle | Thromboxane A2 receptor | Homo sapiens (human) |
| plasma membrane | Thromboxane A2 receptor | Homo sapiens (human) |
| nuclear speck | Thromboxane A2 receptor | Homo sapiens (human) |
| plasma membrane | Thromboxane A2 receptor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID228233 | In vitro thromboxane A2 antagonistic activity on U-46619 (0.1 uM) induced contraction of rat aorta | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives. |
| AID224471 | In vitro thromboxane A2 antagonistic activity on aggregation of rabbit platelets induced by U-46,619 (4 uM) | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives. |
| AID223206 | Ex vivo inhibitory activity (0.3 mg/kg p.o.) on the aggregation of guinea pig platelets induced by arachidonic acid (100 uM) | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives. |
| AID223207 | Extra vivo inhibitory activity of compound (0.3 mg/kg p.o.) on the aggregation of guinea pig platelets induced by U-46619 (1 uM) | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives. |
| AID222785 | In vitro inhibitory activity for the aggregation of human platelets induced by U-46,619 (1 uM) was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives. |
| AID223205 | In vitro inhibitory activity for the aggregation of guinea pig platelets induced by U-46,619 (4 uM) was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives. |
| AID223203 | Extra vivo inhibitory activity of compound for the aggregation of guinea pig platelets induced by U-46,619 (4 uM) was determined | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (46.87) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (11.11%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (88.89%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||