warangalone and Edema

The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H(2)O extract showed to be inactive in all of the assays.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Edema; Flavonoids; Fruit; Isoflavones; Maclura; Male; Mice; Molecular Structure; Pain; Plant Extracts; Solvents; Stomach Ulcer

The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclic AMP-Dependent Protein Kinases; Ear; Edema; Enzyme Inhibitors; Erythrina; Female; Humans; Isoflavones; Leukocytes; Leukotriene B4; Mice; Molecular Structure; Phospholipases A; Plant Bark; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar